Q6KCD5 (NIPBL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nipped-B-like protein

Alternative name(s):
Delangin homolog
SCC2 homolog

Gene names

Name:

Nipbl

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2798 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex By similarity.
Subcellular location	Nucleus By similarity.
Developmental stage	Widely expressed at E9.5 and E10.5, with notable accumulations in limb bud, branchial arch and craniofacial mesenchyme. These regions are involved in patterning of the skeleton and soft tissues of the limbs, jaw and face. Ref.4
Sequence similarities	Belongs to the SCC2/Nipped-B family. Contains 5 HEAT repeats.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from electronic annotation. Source: Compara cellular protein localization Inferred from electronic annotation. Source: Compara cellular response to X-ray Inferred from electronic annotation. Source: Compara cognition Inferred from electronic annotation. Source: Compara developmental growth Inferred from electronic annotation. Source: Compara ear morphogenesis Inferred from electronic annotation. Source: Compara embryonic digestive tract morphogenesis Inferred from electronic annotation. Source: Compara embryonic forelimb morphogenesis Inferred from electronic annotation. Source: Compara embryonic viscerocranium morphogenesis Inferred from mutant phenotype PubMed 19763162. Source: MGI external genitalia morphogenesis Inferred from electronic annotation. Source: Compara eye morphogenesis Inferred from electronic annotation. Source: Compara face morphogenesis Inferred from electronic annotation. Source: Compara fat cell differentiation Inferred from mutant phenotype PubMed 19763162. Source: MGI gall bladder development Inferred from electronic annotation. Source: Compara heart development Inferred from mutant phenotype PubMed 19763162. Source: MGI maintenance of mitotic sister chromatid cohesion Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara outflow tract morphogenesis Inferred from electronic annotation. Source: Compara positive regulation of histone deacetylation Inferred from electronic annotation. Source: Compara positive regulation of multicellular organism growth Inferred from mutant phenotype PubMed 19763162. Source: MGI positive regulation of ossification Inferred from mutant phenotype PubMed 19763162. Source: MGI regulation of developmental growth Inferred from electronic annotation. Source: Compara regulation of embryonic development Inferred from electronic annotation. Source: Compara regulation of hair cycle Inferred from electronic annotation. Source: Compara response to DNA damage stimulus Inferred from electronic annotation. Source: Compara sensory perception of sound Inferred from electronic annotation. Source: Compara stem cell maintenance Inferred from mutant phenotype PubMed 20720539. Source: MGI uterus morphogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	SMC loading complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	chromatin binding Inferred from direct assay PubMed 20720539. Source: MGI mediator complex binding Inferred from direct assay PubMed 20720539. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6KCD5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6KCD5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2678-2691: SLRRSKRNSDSTEL → VRRRRSQRISQRIT
     2692-2798: Missing.

Isoform 3 (identifier: Q6KCD5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-2694: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6KCD5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     499-556: DKPLKKRKQD...QAGRVDSQAS → GKGPLSLLLQ...NYITLFELLY
     557-2798: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2798	2798	Nipped-B-like protein		PRO_0000218597
Regions
	Repeat	1761 – 1799	39	HEAT 1
	Repeat	1837 – 1875	39	HEAT 2
	Repeat	1939 – 1978	40	HEAT 3
	Repeat	2221 – 2261	41	HEAT 4
	Repeat	2307 – 2345	39	HEAT 5
	Compositional bias	418 – 462	45	Gln-rich
Amino acid modifications
	Modified residue	150	1	Phosphoserine By similarity
	Modified residue	162	1	Phosphoserine By similarity
	Modified residue	256	1	Phosphoserine By similarity
	Modified residue	280	1	Phosphoserine Ref.6
	Modified residue	306	1	Phosphoserine By similarity
	Modified residue	318	1	Phosphoserine By similarity
	Modified residue	350	1	Phosphoserine By similarity
	Modified residue	553	1	Phosphoserine Ref.7
	Modified residue	558	1	Phosphothreonine Ref.7
	Modified residue	713	1	Phosphothreonine By similarity
	Modified residue	746	1	Phosphothreonine By similarity
	Modified residue	906	1	Phosphoserine By similarity
	Modified residue	1083	1	Phosphoserine By similarity
	Modified residue	1084	1	Phosphoserine By similarity
	Modified residue	1090	1	Phosphoserine By similarity
	Modified residue	1144	1	Phosphoserine By similarity
	Modified residue	1146	1	Phosphoserine By similarity
	Modified residue	1148	1	Phosphoserine By similarity
	Modified residue	1154	1	Phosphoserine By similarity
	Modified residue	1452	1	Phosphothreonine Ref.8
	Modified residue	1453	1	Phosphoserine Ref.8
	Modified residue	2503	1	Phosphoserine By similarity
	Modified residue	2505	1	Phosphoserine By similarity
	Modified residue	2507	1	Phosphoserine By similarity
	Modified residue	2509	1	Phosphoserine By similarity
	Modified residue	2652	1	Phosphoserine Ref.8
	Modified residue	2661	1	Phosphothreonine Ref.6
	Modified residue	2666	1	Phosphoserine Ref.5 Ref.6
Natural variations
	Alternative sequence	1 – 2694	2694	Missing in isoform 3.		VSP_011094
	Alternative sequence	1 – 263	263	Missing in isoform 4.		VSP_011095
	Alternative sequence	499 – 556	58	DKPLK…DSQAS → GKGPLSLLLQHLATCVLIPT SLLRYEFHSLAEASISDLII QYHRLSNLNYITLFELLY in isoform 4.		VSP_011096
	Alternative sequence	557 – 2798	2242	Missing in isoform 4.		VSP_011097
	Alternative sequence	2678 – 2691	14	SLRRS…DSTEL → VRRRRSQRISQRIT in isoform 2.		VSP_011098
	Alternative sequence	2692 – 2798	107	Missing in isoform 2.		VSP_011099
Experimental info
	Sequence conflict	2577	1	K → I in BAC25453. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BC23B6E2C949C9B3	FASTA	2,798	315,450
	10 20 30 40 50 60 MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV NCLLACRDDN 70 80 90 100 110 120 LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL ARSPNVFREK SMQNRYVQSG 130 140 150 160 170 180 MMMSQYKLSQ NSMHSSPASS NYQQTTISHS PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP 190 200 210 220 230 240 QSPAGYMPYS HPSSYTTHPQ MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR 250 260 270 280 290 300 HGSSDDYLHM VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ 310 320 330 340 350 360 SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS PTKDSTKLTL 370 380 390 400 410 420 RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT SKTPITPQDV NRPLNAAQCL 430 440 450 460 470 480 SQQEQTAFLP ANQVPVLQQN TSVATKQPQT SVVQNQQQVS QQGPIYDEVE LDALAEIERI 490 500 510 520 530 540 ERESAIERER FSKEVQDKDK PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM 550 560 570 580 590 600 VSIDLHQAGR VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP 610 620 630 640 650 660 KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE LKQNENKTTE 670 680 690 700 710 720 SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP ETPKQKAESR PETPKQKSEG 730 740 750 760 770 780 RPETPKQKGD GRPETPKQKS EGRPETPKQK GEGRPETPKH RHENRRDSGK PSTEKKPDVS 790 800 810 820 830 840 KHKQDIKSDS PRLKSERAEA LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR 850 860 870 880 890 900 PETLRSSSRN DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS 910 920 930 940 950 960 RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF VIPKIKRDKD 970 980 990 1000 1010 1020 GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ KLSLDDVQKL IKDREEKSRS 1030 1040 1050 1060 1070 1080 SLKSIKNKPS KSNKGSIDQS VLKELPPELL AEIESTMPLC ERVKMNKRKR STVNEKPKYA 1090 1100 1110 1120 1130 1140 EISSDEDNDS DEAFESSRKR HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY 1150 1160 1170 1180 1190 1200 RNRSPSDSDM EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI 1210 1220 1230 1240 1250 1260 ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK LSTDKTVKVL 1270 1280 1290 1300 1310 1320 NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK SADACLTTIN IMTSPNMPKA 1330 1340 1350 1360 1370 1380 VYIEDVIERV IQYTKFHLQN TLYPQYDPVY RVDPHGGGLL SSKAKRAKCS THKQRVIVML 1390 1400 1410 1420 1430 1440 YNKVCDIVSS LSELLEIQLL TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE 1450 1460 1470 1480 1490 1500 KHRQLILEEI FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS 1510 1520 1530 1540 1550 1560 SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE DYRPLFENFV 1570 1580 1590 1600 1610 1620 QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR VASLDYLGTV AARLRKDAVT 1630 1640 1650 1660 1670 1680 SKMDQGSIER ILKQVSGGED EIQQLQKALL DYLDENTETD PSLVFSRKFY IAQWFRDTTL 1690 1700 1710 1720 1730 1740 ETEKAMKSQK DEESSDATHH AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD 1750 1760 1770 1780 1790 1800 TVDYDDACLI VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI 1810 1820 1830 1840 1850 1860 LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER ILDTGISVRK 1870 1880 1890 1900 1910 1920 RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV NETFQKLWFT PTPHNDKEAM 1930 1940 1950 1960 1970 1980 TRKILNITDV VAACRDTGYD WFEQLLQNLL KSEEDSSYKP VKKACTQLVD NLVEHILKYE 1990 2000 2010 2020 2030 2040 ESLADSDNKG VNSGRLVACI TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN 2050 2060 2070 2080 2090 2100 VAKILELVVP LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV 2110 2120 2130 2140 2150 2160 WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF DLEDFKGNSK 2170 2180 2190 2200 2210 2220 VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL MFEQEVKNLY NSILSDKNSS 2230 2240 2250 2260 2270 2280 VNLKIQVLKN LQTYLQEEDT RMQQADRDWK KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV 2290 2300 2310 2320 2330 2340 LEAFFHTQSS VRHFALNVIA LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID 2350 2360 2370 2380 2390 2400 KKYAGFIHMK AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR 2410 2420 2430 2440 2450 2460 RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT LSVSGSNLLQ 2470 2480 2490 2500 2510 2520 SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR VDSESDSDSE DDINSVMKCL 2530 2540 2550 2560 2570 2580 PENSAPLIEF ANVSQGILLL LMLKQHLKNL CGFSDSKIQK YSPSESAKVY DKAINRKTGV 2590 2600 2610 2620 2630 2640 HFHPKQTLDF LRSDMANSKL TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR 2650 2660 2670 2680 2690 2700 NKAITSLLGG GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD 2710 2720 2730 2740 2750 2760 VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG RKLVPWVDTI 2770 2780 2790 KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS
	Isoform 2 [UniParc]. Checksum: 15871B1EF11857A7	FASTA	2,691	303,763
	10 20 30 40 50 60 MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV NCLLACRDDN 70 80 90 100 110 120 LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL ARSPNVFREK SMQNRYVQSG 130 140 150 160 170 180 MMMSQYKLSQ NSMHSSPASS NYQQTTISHS PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP 190 200 210 220 230 240 QSPAGYMPYS HPSSYTTHPQ MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR 250 260 270 280 290 300 HGSSDDYLHM VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ 310 320 330 340 350 360 SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS PTKDSTKLTL 370 380 390 400 410 420 RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT SKTPITPQDV NRPLNAAQCL 430 440 450 460 470 480 SQQEQTAFLP ANQVPVLQQN TSVATKQPQT SVVQNQQQVS QQGPIYDEVE LDALAEIERI 490 500 510 520 530 540 ERESAIERER FSKEVQDKDK PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM 550 560 570 580 590 600 VSIDLHQAGR VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP 610 620 630 640 650 660 KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE LKQNENKTTE 670 680 690 700 710 720 SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP ETPKQKAESR PETPKQKSEG 730 740 750 760 770 780 RPETPKQKGD GRPETPKQKS EGRPETPKQK GEGRPETPKH RHENRRDSGK PSTEKKPDVS 790 800 810 820 830 840 KHKQDIKSDS PRLKSERAEA LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR 850 860 870 880 890 900 PETLRSSSRN DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS 910 920 930 940 950 960 RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF VIPKIKRDKD 970 980 990 1000 1010 1020 GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ KLSLDDVQKL IKDREEKSRS 1030 1040 1050 1060 1070 1080 SLKSIKNKPS KSNKGSIDQS VLKELPPELL AEIESTMPLC ERVKMNKRKR STVNEKPKYA 1090 1100 1110 1120 1130 1140 EISSDEDNDS DEAFESSRKR HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY 1150 1160 1170 1180 1190 1200 RNRSPSDSDM EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI 1210 1220 1230 1240 1250 1260 ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK LSTDKTVKVL 1270 1280 1290 1300 1310 1320 NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK SADACLTTIN IMTSPNMPKA 1330 1340 1350 1360 1370 1380 VYIEDVIERV IQYTKFHLQN TLYPQYDPVY RVDPHGGGLL SSKAKRAKCS THKQRVIVML 1390 1400 1410 1420 1430 1440 YNKVCDIVSS LSELLEIQLL TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE 1450 1460 1470 1480 1490 1500 KHRQLILEEI FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS 1510 1520 1530 1540 1550 1560 SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE DYRPLFENFV 1570 1580 1590 1600 1610 1620 QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR VASLDYLGTV AARLRKDAVT 1630 1640 1650 1660 1670 1680 SKMDQGSIER ILKQVSGGED EIQQLQKALL DYLDENTETD PSLVFSRKFY IAQWFRDTTL 1690 1700 1710 1720 1730 1740 ETEKAMKSQK DEESSDATHH AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD 1750 1760 1770 1780 1790 1800 TVDYDDACLI VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI 1810 1820 1830 1840 1850 1860 LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER ILDTGISVRK 1870 1880 1890 1900 1910 1920 RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV NETFQKLWFT PTPHNDKEAM 1930 1940 1950 1960 1970 1980 TRKILNITDV VAACRDTGYD WFEQLLQNLL KSEEDSSYKP VKKACTQLVD NLVEHILKYE 1990 2000 2010 2020 2030 2040 ESLADSDNKG VNSGRLVACI TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN 2050 2060 2070 2080 2090 2100 VAKILELVVP LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV 2110 2120 2130 2140 2150 2160 WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF DLEDFKGNSK 2170 2180 2190 2200 2210 2220 VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL MFEQEVKNLY NSILSDKNSS 2230 2240 2250 2260 2270 2280 VNLKIQVLKN LQTYLQEEDT RMQQADRDWK KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV 2290 2300 2310 2320 2330 2340 LEAFFHTQSS VRHFALNVIA LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID 2350 2360 2370 2380 2390 2400 KKYAGFIHMK AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR 2410 2420 2430 2440 2450 2460 RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT LSVSGSNLLQ 2470 2480 2490 2500 2510 2520 SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR VDSESDSDSE DDINSVMKCL 2530 2540 2550 2560 2570 2580 PENSAPLIEF ANVSQGILLL LMLKQHLKNL CGFSDSKIQK YSPSESAKVY DKAINRKTGV 2590 2600 2610 2620 2630 2640 HFHPKQTLDF LRSDMANSKL TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR 2650 2660 2670 2680 2690 NKAITSLLGG GSPKNNTAAD TEDEESDGED RGGGTSGVRR RRSQRISQRI T
	Isoform 3 [UniParc]. Checksum: 48CCA6BE60A266F2	FASTA	104	11,598
	10 20 30 40 50 60 MNESVDVMDV IAICCPKYKD RPQIARVVQR TSSGVSVQWM AGSYSGSWTE AKRRDGRKLV 70 80 90 100 PWVDTIKESD IIYKKIALTS ANKLTNKVVQ TLRSLYAAKD GTSS
	Isoform 4 [UniParc]. Checksum: 946EB9CB53827AE3	FASTA	293	32,742
	10 20 30 40 50 60 MRNAASFPLR SPQPVCSPAG SDGTPKGSRP PLILQSQSLP CSSPRDVPPD ILLDSPERKQ 70 80 90 100 110 120 KKQKKIKLGK DEKDQNEKAA MYDIISSPTK DSTKLTLRLS RVRSSDMDQQ DDMLSGMENS 130 140 150 160 170 180 NVSENDIPFN VQYPGQTSKT PITPQDVNRP LNAAQCLSQQ EQTAFLPANQ VPVLQQNTSV 190 200 210 220 230 240 ATKQPQTSVV QNQQQVSQQG PIYDEVELDA LAEIERIERE SAIERERFSK EVQDKGKGPL 250 260 270 280 290 SLLLQHLATC VLIPTSLLRY EFHSLAEASI SDLIIQYHRL SNLNYITLFE LLY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome." Tonkin E.T., Wang T.-J., Lisgo S., Bamshad M.J., Strachan T. Nat. Genet. 36:636-641(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-325, NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2575-2798 (ISOFORM 2). Strain: C57BL/6J. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: C57BL/6. Tissue: Brain.
[4]	"Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B." Krantz I.D., McCallum J., DeScipio C., Kaur M., Gillis L.A., Yaeger D., Jukofsky L., Wasserman N., Bottani A., Morris C.A., Nowaczyk M.J.M., Toriello H., Bamshad M.J., Carey J.C., Rappaport E., Kawauchi S., Lander A.D., Calof A.L. , Li H.-H., Devoto M., Jackson L.G. Nat. Genet. 36:631-635(2004) [PubMed] [Europe PMC] [Abstract] Cited for: DEVELOPMENTAL STAGE.
[5]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2666, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280; THR-2661 AND SER-2666, MASS SPECTROMETRY. Tissue: Liver.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553 AND THR-558, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1452; SER-1453 AND SER-2652, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ627033 mRNA. Translation: CAF25291.1. AJ640138 mRNA. Translation: CAG26692.1. AK014915 mRNA. Translation: BAC25453.1. AK016861 mRNA. Translation: BAB30471.1. AK049588 mRNA. Translation: BAC33829.1. BC055787 mRNA. Translation: AAH55787.1.
IPI	IPI00357096. IPI00377849. IPI00380342. IPI00421052.
RefSeq	NP_081983.2. NM_027707.2. NP_957684.1. NM_201232.1.
UniGene	Mm.240329. Mm.440537.
3D structure databases
ProteinModelPortal	Q6KCD5.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-56622N.
IntAct	Q6KCD5. 3 interactions.
PTM databases
PhosphoSite	Q6KCD5.
Proteomic databases
PaxDb	Q6KCD5.
PRIDE	Q6KCD5.
Protocols and materials databases
DNASU	71175.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000052965; ENSMUSP00000059385; ENSMUSG00000022141.
GeneID	71175.
KEGG	mmu:71175.
UCSC	uc007veq.1. mouse. uc007ver.1. mouse. uc007vev.1. mouse.
Organism-specific databases
CTD	25836.
MGI	MGI:1913976. Nipbl.
Phylogenomic databases
eggNOG	NOG128278.
GeneTree	ENSGT00390000010427.
HOGENOM	HOG000113787.
HOVERGEN	HBG052626.
InParanoid	Q6KCD5.
KO	K06672.
OMA	HESGDSR.
OrthoDB	EOG4001HC.
Gene expression databases
Bgee	Q6KCD5.
CleanEx	MM_NIPBL.
Genevestigator	Q6KCD5.
GermOnline	ENSMUSG00000022141. Mus musculus.
Family and domain databases
Gene3D	1.25.10.10. 4 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR026003. Cohesin_HEAT. IPR024986. Nipped-B_C. [Graphical view]
Pfam	PF12765. Cohesin_HEAT. 1 hit. PF12830. Nipped-B_C. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	333221.
SOURCE	Search...

Entry information

Entry name

NIPBL_MOUSE

Accession

Primary (citable) accession number: Q6KCD5
Secondary accession number(s): Q6KC78 , Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program