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Protein

Actin-binding LIM protein 2

Gene

Ablim2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc 1By similarity1
Metal bindingi86Zinc 1By similarity1
Metal bindingi103Zinc 1By similarity1
Metal bindingi106Zinc 1By similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi131Zinc 2By similarity1
Metal bindingi134Zinc 2By similarity1
Metal bindingi212Zinc 3By similarity1
Metal bindingi215Zinc 3By similarity1
Metal bindingi232Zinc 3By similarity1
Metal bindingi235Zinc 3By similarity1
Metal bindingi238Zinc 4By similarity1
Metal bindingi241Zinc 4By similarity1
Metal bindingi260Zinc 4By similarity1
Metal bindingi263Zinc 4By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding LIM protein 2
Short name:
abLIM-2
Alternative name(s):
Actin-binding LIM protein family member 2
Gene namesi
Name:Ablim2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303094. Ablim2.

Subcellular locationi

  • Cytoplasm

  • Note: In skeletal muscle, sarcomeric or cosarcomeric localization.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000757011 – 612Actin-binding LIM protein 2Add BLAST612

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei282PhosphoserineCombined sources1
Modified residuei294PhosphoserineBy similarity1
Modified residuei365PhosphoserineCombined sources1
Modified residuei368PhosphoserineBy similarity1
Modified residuei453PhosphoserineCombined sources1
Modified residuei473PhosphothreonineBy similarity1
Modified residuei477PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6KC51.
PRIDEiQ6KC51.

PTM databases

iPTMnetiQ6KC51.
PhosphoSitePlusiQ6KC51.
SwissPalmiQ6KC51.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007882.
GenevisibleiQ6KC51. RN.

Interactioni

Subunit structurei

Interacts with F-actin and ABRA.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055116.

Structurei

3D structure databases

ProteinModelPortaliQ6KC51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 81LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST60
Domaini81 – 141LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini151 – 210LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST60
Domaini210 – 270LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST61
Domaini544 – 612HPPROSITE-ProRule annotationAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi364 – 412Ser-richAdd BLAST49

Sequence similaritiesi

Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation
Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ6KC51.
KOiK07520.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProiIPR028450. ABLIM2.
IPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24213:SF6. PTHR24213:SF6. 1 hit.
PfamiPF16182. AbLIM_anchor. 2 hits.
PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6KC51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAVSQPQAA HAPLEKPAST AILCNTCGNV CKGEVLRVQN KHFHIRCFVC
60 70 80 90 100
KACGCDLAEG GFFVRQGEHI CTRDYQRLYG TRCFSCDCFI EGEVVSALGK
110 120 130 140 150
TYHPDCFVCA VCRLPFPPGD RVTFNGKDCM CQKCSPPTLV GNSAHVAQGL
160 170 180 190 200
RSCGGCGLEI KNGQALVALD KHWHLGCFKC KTCGKLLNAE YISKDGLPYC
210 220 230 240 250
EADYHTKFGI RCDGCEKYIT GRVLEAGEKH YHPSCALCVR CGQMFSEGEE
260 270 280 290 300
MYLQGSSIWH PACRQAARTE DKSKETRTSS ESIVSVPASS TSGSPSRVIY
310 320 330 340 350
AKLGDEILDY RDLAALPKNK AIYNIDRPDM ISYSPYISHS AVGDRQSYGE
360 370 380 390 400
GDQDDRSYKQ CRTSSPSSAG SVSLGHYTPT SRSPQHYSRP GSESGRSTPS
410 420 430 440 450
LSVHSDSRPP SSTYQQAPRH FHVPDTGVKD NIYRKPPIYK QHAARRLDVE
460 470 480 490 500
DSSFDQDSRK KTTWLLLKGD ADTRTNSPDL DSQSLSLSSG ADQEPLQRMP
510 520 530 540 550
GDSLYSRFPY SKPDTLPGPR KDGLDLRNAN LAPCGADPDA SWGTREYKIY
560 570 580 590 600
PYDSLIVTNR IRVKLPKDVD RTRLERHLSP EEFQEVFGMS IEEFDRLALW
610
KRNDLKKKAL LF
Length:612
Mass (Da):68,010
Last modified:July 5, 2004 - v1
Checksum:iB6B6E27365D00B26
GO
Isoform 2 (identifier: Q6KC51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     507-546: RFPYSKPDTLPGPRKDGLDLRNANLAPCGADPDASWGTRE → Q

Show »
Length:573
Mass (Da):63,800
Checksum:i5C9C8C775682FB66
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012125507 – 546RFPYS…WGTRE → Q in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ703892 mRNA. Translation: CAG28314.1.
AJ703893 mRNA. Translation: CAG28315.1.
RefSeqiNP_001001514.1. NM_001001514.2. [Q6KC51-2]
NP_001171166.1. NM_001177695.1. [Q6KC51-1]
UniGeneiRn.131797.

Genome annotation databases

GeneIDi360958.
KEGGirno:360958.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ703892 mRNA. Translation: CAG28314.1.
AJ703893 mRNA. Translation: CAG28315.1.
RefSeqiNP_001001514.1. NM_001001514.2. [Q6KC51-2]
NP_001171166.1. NM_001177695.1. [Q6KC51-1]
UniGeneiRn.131797.

3D structure databases

ProteinModelPortaliQ6KC51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055116.

PTM databases

iPTMnetiQ6KC51.
PhosphoSitePlusiQ6KC51.
SwissPalmiQ6KC51.

Proteomic databases

PaxDbiQ6KC51.
PRIDEiQ6KC51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360958.
KEGGirno:360958.

Organism-specific databases

CTDi84448.
RGDi1303094. Ablim2.

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ6KC51.
KOiK07520.

Miscellaneous databases

PROiQ6KC51.

Gene expression databases

BgeeiENSRNOG00000007882.
GenevisibleiQ6KC51. RN.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProiIPR028450. ABLIM2.
IPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24213:SF6. PTHR24213:SF6. 1 hit.
PfamiPF16182. AbLIM_anchor. 2 hits.
PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABLM2_RAT
AccessioniPrimary (citable) accession number: Q6KC51
Secondary accession number(s): Q6KC50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.