ID   Q6KC10_TAKRU            Unreviewed;       366 AA.
AC   Q6KC10;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Alpha-2,8-sialyltransferase ST8Sia II {ECO:0000313|EMBL:CAG29377.1};
DE            EC=2.4.99.8 {ECO:0000313|EMBL:CAG29377.1};
DE   Flags: Fragment;
GN   Name=siat 8B {ECO:0000313|EMBL:CAG29377.1};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|EMBL:CAG29377.1};
RN   [1] {ECO:0000313|EMBL:CAG29377.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15843597; DOI=10.1093/glycob/cwi063;
RA   Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.;
RT   "The animal sialyltransferases and sialyltransferase-related genes: a
RT   phylogenetic approach.";
RL   Glycobiology 15:805-817(2005).
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 29 family.
CC       {ECO:0000256|ARBA:ARBA00006003}.
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DR   EMBL; AJ715538; CAG29377.1; -; mRNA.
DR   AlphaFoldDB; Q6KC10; -.
DR   CAZy; GT29; Glycosyltransferase Family 29.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008373; F:sialyltransferase activity; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   Gene3D; 3.90.1480.20; Glycosyl transferase family 29; 1.
DR   InterPro; IPR001675; Glyco_trans_29.
DR   InterPro; IPR038578; GT29-like_sf.
DR   InterPro; IPR012163; Sialyl_trans.
DR   PANTHER; PTHR11987; ALPHA-2,8-SIALYLTRANSFERASE; 1.
DR   PANTHER; PTHR11987:SF30; ALPHA-2,8-SIALYLTRANSFERASE 8B; 1.
DR   Pfam; PF00777; Glyco_transf_29; 1.
DR   PIRSF; PIRSF005557; Sialyl_trans; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:CAG29377.1};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAG29377.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..366
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004275641"
FT   DISULFID        140..290
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005557-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAG29377.1"
FT   NON_TER         366
FT                   /evidence="ECO:0000313|EMBL:CAG29377.1"
SQ   SEQUENCE   366 AA;  41814 MW;  B2C7293D7A869392 CRC64;
     MPLGFRTLLF GFVTLGAVVL IIDDIAQVEE EAAETEPQLN PTALTKSNKA VNHLVPSFSN
     AAKIQSSNWT FNKTLSMLIR KSILRFLDPE RDISILKGTL KPGDIVHYVF DRHSTTNVSE
     TLYHFLPTVS PMKNQHHRRC AIVGNSGILL NSSCGPEIDS HDFVIRCNLA PVEDYYKDVG
     WRTNLVTMNP SVVQRAFRDL ASEEWRARFL RRLQSLSGSV LWIPAFMAKG GEERVEWTLR
     LILLHTVDVR TAFPSLRLLH AVRGYWLTNN VHIKRPTTGL LMYTMATRFC EEIHLYGFWP
     FPSDPHGRPV KYHYYDTLKY EYTSSSSPHT MPLEFRTLSS LHRQGALQLH TGPCDTGRQP
     QDQPHE
//