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Protein
Submitted name:

Alpha-2,8-sialyltransferase ST8Sia IV

Gene

st8sia4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: ZFIN
  • sialyltransferase activity Source: ZFIN

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseSAAS annotationImported, Transferase

Enzyme and pathway databases

ReactomeiR-DRE-4085001. Sialic acid metabolism.
R-DRE-419037. NCAM1 interactions.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2,8-sialyltransferase ST8Sia IVImported (EC:2.4.99.8Imported)
Submitted name:
N-glycan alpha 2,8-sialyltransferaseImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:st8sia4Imported
Synonyms:pstImported, siat 8DImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-060322-10. st8sia4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatusSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 358332Sequence analysisPRO_5007708624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi141 ↔ 291UniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011180.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00550000074407.
HOGENOMiHOG000232070.
HOVERGENiHBG056466.
KOiK06614.
OMAiSVRKRWT.
OrthoDBiEOG7VQJD1.
TreeFamiTF352820.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q6KC03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSRKHWTV CTISVLLVLF YKTTDIGRNE VHQKASLTWY LEPSATRLMA
60 70 80 90 100
NGSEKLFGNV LNGLDLGVGW KINATLVSII RKDILRYLDA ERDVSVIKSN
110 120 130 140 150
FKPGDTIRYV LDRRRTFSVS QTLHSLLPEV SPLKNKTFKT CAVVGNSGIL
160 170 180 190 200
LKSGCGKEID NHSFVIRCNL APLEGFADDV GLRSDFTTMN PSVIQRVYGG
210 220 230 240 250
LREETQQENL IQRLRQLNDS VLWIPAFMVK GGMKHVDTVN ELILKHKLKV
260 270 280 290 300
RTAYPSLRLI HAVRGFWLTN KINIKRPTTG LLMYTMATRF CDEIYLYGFW
310 320 330 340 350
PFPKDASGNP VQYHYFDGLK YRYFSNAGPH RMPLEFQTLQ RLHSKGALKL

TTSKCTST
Length:358
Mass (Da):40,837
Last modified:July 5, 2004 - v1
Checksum:iD720FB85BEF4872B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei358 – 3581Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294128 Genomic DNA. No translation available.
CU896666 Genomic DNA. No translation available.
DQ779599 mRNA. Translation: ABG77976.1.
AJ715545 mRNA. Translation: CAG29384.1.
RefSeqiNP_001092886.1. NM_001099416.1.
UniGeneiDr.91772.

Genome annotation databases

EnsembliENSDART00000157776; ENSDARP00000135219; ENSDARG00000103600.
ENSDART00000170062; ENSDARP00000131324; ENSDARG00000103600.
GeneIDi553211.
KEGGidre:553211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX294128 Genomic DNA. No translation available.
CU896666 Genomic DNA. No translation available.
DQ779599 mRNA. Translation: ABG77976.1.
AJ715545 mRNA. Translation: CAG29384.1.
RefSeqiNP_001092886.1. NM_001099416.1.
UniGeneiDr.91772.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000011180.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000157776; ENSDARP00000135219; ENSDARG00000103600.
ENSDART00000170062; ENSDARP00000131324; ENSDARG00000103600.
GeneIDi553211.
KEGGidre:553211.

Organism-specific databases

CTDi7903.
ZFINiZDB-GENE-060322-10. st8sia4.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00550000074407.
HOGENOMiHOG000232070.
HOVERGENiHBG056466.
KOiK06614.
OMAiSVRKRWT.
OrthoDBiEOG7VQJD1.
TreeFamiTF352820.

Enzyme and pathway databases

ReactomeiR-DRE-4085001. Sialic acid metabolism.
R-DRE-419037. NCAM1 interactions.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
    Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
    Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Divergent evolution of the vertebrate polysialyltransferase Stx and Pst genes revealed by fish-to-mammal comparison."
    Marx M., Rivera-Milla E., Stummeyer K., Gerardy-Schahn R., Bastmeyer M.
    Dev. Biol. 306:560-571(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  4. Ensembl
    Submitted (NOV-2015) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ6KC03_DANRE
AccessioniPrimary (citable) accession number: Q6KC03
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.