Reviewed, UniProtKB/Swiss-Prot Q6KBA8 (FKB1A_EMENI)

Names and origin

Protein names

Recommended name:
    FK506-binding protein 1A
      Short name=FKBP
      Short name=FkbA
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
    Rapamycin-binding protein

Gene names

Name:	fprA
ORF Names:	AN3598

Organism

Emericella nidulans (Aspergillus nidulans) [Complete proteome]

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain.
Sequence caution	The sequence EAA59806.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 108	108	FK506-binding protein 1A		PRO_0000233325
Regions
	Domain	20 – 108	89	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	Q6KBA8-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 02A17185E5C999EB	FASTA	108	11,592
	10 20 30 40 50 60 MGVEVQRISP GDGKNFPKPG DTVSIHYTGT LADGSKFDSS RDRPGTFVTQ IGVGRVIKGW 70 80 90 100 DEGVLQLSVG EKAKLICTPD YAYGARGFPP VIPPNATLTF EVELLKIN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic Analysis of the TOR Pathway in Aspergillus nidulans." Fitzgibbon G.J., Morozov I.Y., Jones M.G., Caddick M.X. Eukaryot. Cell 4:1595-1598(2005) [PubMed: 16151253] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Rapamycin resistant mutations in fkbA encoding a FK506-binding protein of Aspergillus nidulans." Cha M.-J., Lee J.-W., Sohn C., Kwon N.-J., Chae S.-K. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ717400 Genomic DNA. Translation: CAG30551.1. DQ185030 Genomic DNA. Translation: ABA26696.1. AACD01000061 Genomic DNA. Translation: EAA59806.1. Sequence problems.
RefSeq	XP_661202.1.
3D structure databases
HSSP	HSSP built from PDB template 1JVW based on UniProtKB Q09734.
ModBase	Search...
Genome annotation databases
GeneID	2873015.
KEGG	ani:AN3598.2.
Enzyme and pathway databases
BRENDA	5.2.1.8. 3859.
Family and domain databases
InterPro	IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKB1A_EMENI

Accession

Primary (citable) accession number: Q6KBA8
Secondary accession number(s): Q5B782

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	July 5, 2004
Last modified:	September 22, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)