Keratin, type II cytoskeletal 80 - Homo sapiens (Human)

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Q6KB66 (K2C80_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Keratin, type II cytoskeletal 80

Alternative name(s):
Cytokeratin-80
Short name=CK-80
Keratin-80
Short name=K80
Type-II keratin Kb20

Gene names

Name:	KRT80
Synonyms:	KB20

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	452 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterotetramer of two type I and two type II keratins.
Tissue specificity	Weakly expressed in tongue, but not skin or in any other tissues or organs examined. Ref.1
Miscellaneous	There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	keratin filament Inferred from electronic annotation. Source: InterPro
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6KB66-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6KB66-2) The sequence of this isoform differs from the canonical sequence as follows: 413-452: ASRSGLSKAPSRKKKGSKGPVIKITEMSEKYFSQESEVSE → PSLPYPLCSL

Isoform 3 (identifier: Q6KB66-3) The sequence of this isoform differs from the canonical sequence as follows: 1-100: MACRSCVVGF...NDKFASLIGK → MSCHFPGSPP...DPFAAFLLSQ 190-190: K → KVACPACPRG...PTTHHCCQPQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 452

452

Keratin, type II cytoskeletal 80

PRO_0000314896

Regions

Region

1 – 82

Head

Region

82 – 118

Coil 1A

Region

83 – 390

308

Rod

Region

119 – 135

Linker 1

Region

136 – 227

Coil 1B

Region

228 – 251

Linker 12

Region

252 – 390

139

Coil 2

Region

391 – 452

Tail

Sites

Site

334

Stutter

Amino acid modifications

Modified residue

Phosphoserine Ref.6

Modified residue

396

Phosphoserine Ref.6

Natural variations

Alternative sequence

1 – 100

100

MACRS…SLIGK → MSCHFPGSPPWALAGQPGAS APDWSTPDPFAAFLLSQ in isoform 3.

VSP_030421

Alternative sequence

190

K → KVACPACPRGSFLMGPGPSF PPDILLSFMPNQSPQRLKSQ DQQTDRGIPPSPSSSFFEAL SQISSGITPTLTQEAAPQPT PALGPSIPSPTTHHCCQPQ in isoform 3.

VSP_030422

Alternative sequence

413 – 452

ASRSG…SEVSE → PSLPYPLCSL in isoform 2.

VSP_030423

Natural variant

238

V → I.
Corresponds to variant rs35725856 [ dbSNP | Ensembl ].

VAR_049807

Experimental info

Sequence conflict

230

Q → L in CAG30732. Ref.1

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: BC54C53D0566FEA3 Show »	FASTA	452	50,525
10 20 30 40 50 60 MACRSCVVGF SSLSSCEVTP VGSPRPGTSG WDSCRAPGPG FSSRSLTGCW SAGTISKVTV 70 80 90 100 110 120 NPGLLVPLDV KLDPAVQQLK NQEKEEMKAL NDKFASLIGK VQALEQRNQL LETRWSFLQG 130 140 150 160 170 180 QDSAIFDLGH LYEEYQGRLQ EELRKVSQER GQLEANLLQV LEKVEEFRIR YEDEISKRTD 190 200 210 220 230 240 MEFTFVQLKK DLDAECLHRT ELETKLKSLE SFVELMKTIY EQELKDLAAQ VKDVSVTVGM 250 260 270 280 290 300 DSRCHIDLSG IVEEVKAQYD AVAARSLEEA EAYSRSQLEE QAARSAEYGS SLQSSRSEIA 310 320 330 340 350 360 DLNVRIQKLR SQILSVKSHC LKLEENIKTA EEQGELAFQD AKTKLAQLEA ALQQAKQDMA 370 380 390 400 410 420 RQLRKYQELM NVKLALDIEI ATYRKLVEGE EGRMDSPSAT VVSAVQSRCK TAASRSGLSK 430 440 450 APSRKKKGSK GPVIKITEMS EKYFSQESEV SE « Hide
Isoform 2 [UniParc]. Checksum: 0ACF1622662D27E2 Show »	FASTA	422	47,242
10 20 30 40 50 60 MACRSCVVGF SSLSSCEVTP VGSPRPGTSG WDSCRAPGPG FSSRSLTGCW SAGTISKVTV 70 80 90 100 110 120 NPGLLVPLDV KLDPAVQQLK NQEKEEMKAL NDKFASLIGK VQALEQRNQL LETRWSFLQG 130 140 150 160 170 180 QDSAIFDLGH LYEEYQGRLQ EELRKVSQER GQLEANLLQV LEKVEEFRIR YEDEISKRTD 190 200 210 220 230 240 MEFTFVQLKK DLDAECLHRT ELETKLKSLE SFVELMKTIY EQELKDLAAQ VKDVSVTVGM 250 260 270 280 290 300 DSRCHIDLSG IVEEVKAQYD AVAARSLEEA EAYSRSQLEE QAARSAEYGS SLQSSRSEIA 310 320 330 340 350 360 DLNVRIQKLR SQILSVKSHC LKLEENIKTA EEQGELAFQD AKTKLAQLEA ALQQAKQDMA 370 380 390 400 410 420 RQLRKYQELM NVKLALDIEI ATYRKLVEGE EGRMDSPSAT VVSAVQSRCK TAPSLPYPLC SL « Hide
Isoform 3 [UniParc]. Checksum: DF0C64CD3A800AF6 Show »	FASTA	487	54,176
10 20 30 40 50 60 MSCHFPGSPP WALAGQPGAS APDWSTPDPF AAFLLSQVQA LEQRNQLLET RWSFLQGQDS 70 80 90 100 110 120 AIFDLGHLYE EYQGRLQEEL RKVSQERGQL EANLLQVLEK VEEFRIRYED EISKRTDMEF 130 140 150 160 170 180 TFVQLKKVAC PACPRGSFLM GPGPSFPPDI LLSFMPNQSP QRLKSQDQQT DRGIPPSPSS 190 200 210 220 230 240 SFFEALSQIS SGITPTLTQE AAPQPTPALG PSIPSPTTHH CCQPQDLDAE CLHRTELETK 250 260 270 280 290 300 LKSLESFVEL MKTIYEQELK DLAAQVKDVS VTVGMDSRCH IDLSGIVEEV KAQYDAVAAR 310 320 330 340 350 360 SLEEAEAYSR SQLEEQAARS AEYGSSLQSS RSEIADLNVR IQKLRSQILS VKSHCLKLEE 370 380 390 400 410 420 NIKTAEEQGE LAFQDAKTKL AQLEAALQQA KQDMARQLRK YQELMNVKLA LDIEIATYRK 430 440 450 460 470 480 LVEGEEGRMD SPSATVVSAV QSRCKTAASR SGLSKAPSRK KKGSKGPVIK ITEMSEKYFS QESEVSE « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13." Rogers M.A., Edler L., Winter H., Langbein L., Beckmann I., Schweizer J. J. Invest. Dermatol. 124:536-544(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Scalp.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Endometrial adenocarcinoma.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Prostate.
[5]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-396, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ717743 mRNA. Translation: CAG30732.1. BX537567 mRNA. Translation: CAD97784.1. CH471111 Genomic DNA. Translation: EAW58237.1. BC065180 mRNA. Translation: AAH65180.1.
IPI	IPI00375843. IPI00431749. IPI00853265.
RefSeq	NP_001074961.1. NM_001081492.1. NP_872313.2. NM_182507.2.
UniGene	Hs.140978.
3D structure databases
HSSP	HSSP built from PDB template 1GK4 based on UniProtKB P08670.
ProteinModelPortal	Q6KB66.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6KB66. 1 interaction.
STRING	9606.ENSP00000378292.
PTM databases
PhosphoSite	Q6KB66.
Polymorphism databases
DMDM	166218808.
Proteomic databases
PaxDb	Q6KB66.
PRIDE	Q6KB66.
Protocols and materials databases
DNASU	144501.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313234; ENSP00000369361; ENSG00000167767. ENST00000394815; ENSP00000378292; ENSG00000167767.
GeneID	144501.
KEGG	hsa:144501.
UCSC	uc001rzw.3. human. uc001rzx.3. human. uc001rzy.3. human.
Organism-specific databases
CTD	144501.
GeneCards	GC12M052562.
HGNC	HGNC:27056. KRT80.
HPA	HPA040782.
MIM	611161. gene.
neXtProt	NX_Q6KB66.
PharmGKB	PA147357831.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147372.
HOGENOM	HOG000230976.
HOVERGEN	HBG013015.
KO	K07605.
OMA	NQEKEEM.
Gene expression databases
Bgee	Q6KB66.
CleanEx	HS_KRT80.
Genevestigator	Q6KB66.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR003054. Keratin_II. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit. PTHR23239:SF18. PTHR23239:SF18. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01276. TYPE2KERATIN.
PROSITE	PS00226. IF. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	144501.
NextBio	84945.
SOURCE	Search...

Entry information

Entry name

K2C80_HUMAN

Accession

Primary (citable) accession number: Q6KB66
Secondary accession number(s): Q6P1A5, Q7Z3Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 12: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents