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Q6KB55 (SIAT9_PANTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lactosylceramide alpha-2,3-sialyltransferase

EC=2.4.99.9
Alternative name(s):
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Ganglioside GM3 synthase
ST3Gal V
Short name=ST3GalV
Sialyltransferase 9
Gene names
Name:ST3GAL5
Synonyms:SIAT9
OrganismPan troglodytes (Chimpanzee) [Reference proteome]
Taxonomic identifier9598 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide) By similarity.

Catalytic activity

CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Lactosylceramide alpha-2,3-sialyltransferase
PRO_0000149304

Regions

Topological domain1 – 55Cytoplasmic Potential
Transmembrane6 – 2621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain27 – 362336Lumenal Potential

Amino acid modifications

Glycosylation301N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential
Glycosylation2241N-linked (GlcNAc...) Potential
Glycosylation3341N-linked (GlcNAc...) Potential
Disulfide bond139 ↔ 297 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6KB55 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4DD19605E1AB76AD

FASTA36241,714
        10         20         30         40         50         60 
MRRPSLLLKD ILKCTLLVFG VWILYILKLN YTTEECDMKK MHYVDPDRVK RAQTYAQQVL 

        70         80         90        100        110        120 
QKECRPKFAK TSMALLFEHR YSVDLLPFVQ KAPKDSEAES KYDPPFGFRK FSSKVQTLLE 

       130        140        150        160        170        180 
LLPEHDLPEH LKAKTCRRCV VIGSGGILHG LELGHTLNQF DVVIRLNSAP VEGYSEHVGN 

       190        200        210        220        230        240 
KTTIRMTYPE GAPLSDLEYY SNDLFVAVLF KSVDFNWLQA MVKNETLPFW VRLFFWKQVA 

       250        260        270        280        290        300 
EKIPLQPKHF RILNPVIIKE TAFDILQYSE PQSRFWGRDK NVPTIGVIAV VLATHLCDEV 

       310        320        330        340        350        360 
SLAGFGYDLS QPRTPLHYFD NQCMAAMNFQ TMHNVTTETK FLLKLVKEGV VKDLSGGIDR 


EF 

« Hide

References

[1]"Phylogeny of sialyltransferases."
Harduin-Lepers A., Martinez-Duncker I., Mollicone R., Delannoy P., Oriol R.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ744807 mRNA. Translation: CAG32843.1.
RefSeqNP_001032378.1. NM_001037301.1.
UniGenePtr.6348.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9598.ENSPTRP00000057363.

Protein family/group databases

CAZyGT29. Glycosyltransferase Family 29.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPTRT00000022576; ENSPTRP00000020834; ENSPTRG00000012146.
GeneID459371.
KEGGptr:459371.

Organism-specific databases

CTD8869.

Phylogenomic databases

eggNOGNOG257001.
GeneTreeENSGT00620000087815.
HOGENOMHOG000000682.
HOVERGENHBG056676.
InParanoidQ6KB55.
KOK03370.
OMAFFWKQVA.
OrthoDBEOG76X609.
TreeFamTF352819.

Family and domain databases

InterProIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetSearch...

Other

NextBio20839561.

Entry information

Entry nameSIAT9_PANTR
AccessionPrimary (citable) accession number: Q6KB55
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families