Q6KB55 (SIAT9_PANTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lactosylceramide alpha-2,3-sialyltransferase
EC=2.4.99.9

Alternative name(s):
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Ganglioside GM3 synthase
ST3Gal V
Short name=ST3GalV
Sialyltransferase 9

Gene names

Name:	ST3GAL5
Synonyms:	SIAT9

Organism

Pan troglodytes (Chimpanzee) [Reference proteome]

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide) By similarity.
Catalytic activity	CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the glycosyltransferase 29 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein glycosylation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to Golgi membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	lactosylceramide alpha-2,3-sialyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Lactosylceramide alpha-2,3-sialyltransferase		PRO_0000149304
Regions
	Topological domain	1 – 5	5	Cytoplasmic Potential
	Transmembrane	6 – 26	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	27 – 362	336	Lumenal Potential
Amino acid modifications
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Glycosylation	224	1	N-linked (GlcNAc...) Potential
	Glycosylation	334	1	N-linked (GlcNAc...) Potential
	Disulfide bond	139 ↔ 297		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6KB55 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4DD19605E1AB76AD	FASTA	362	41,714
	10 20 30 40 50 60 MRRPSLLLKD ILKCTLLVFG VWILYILKLN YTTEECDMKK MHYVDPDRVK RAQTYAQQVL 70 80 90 100 110 120 QKECRPKFAK TSMALLFEHR YSVDLLPFVQ KAPKDSEAES KYDPPFGFRK FSSKVQTLLE 130 140 150 160 170 180 LLPEHDLPEH LKAKTCRRCV VIGSGGILHG LELGHTLNQF DVVIRLNSAP VEGYSEHVGN 190 200 210 220 230 240 KTTIRMTYPE GAPLSDLEYY SNDLFVAVLF KSVDFNWLQA MVKNETLPFW VRLFFWKQVA 250 260 270 280 290 300 EKIPLQPKHF RILNPVIIKE TAFDILQYSE PQSRFWGRDK NVPTIGVIAV VLATHLCDEV 310 320 330 340 350 360 SLAGFGYDLS QPRTPLHYFD NQCMAAMNFQ TMHNVTTETK FLLKLVKEGV VKDLSGGIDR EF

References

[1]	"Phylogeny of sialyltransferases." Harduin-Lepers A., Martinez-Duncker I., Mollicone R., Delannoy P., Oriol R. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ744807 mRNA. Translation: CAG32843.1.
RefSeq	NP_001032378.1. NM_001037301.1.
UniGene	Ptr.6348.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9598.ENSPTRP00000057363.
Protein family/group databases
CAZy	GT29. Glycosyltransferase Family 29.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPTRT00000022576; ENSPTRP00000020834; ENSPTRG00000012146.
GeneID	459371.
KEGG	ptr:459371.
Organism-specific databases
CTD	8869.
Phylogenomic databases
eggNOG	NOG257001.
GeneTree	ENSGT00620000087815.
HOGENOM	HOG000000682.
HOVERGEN	HBG056676.
InParanoid	Q6KB55.
KO	K03370.
OMA	FFWKQVA.
OrthoDB	EOG47PX6C.
Family and domain databases
InterPro	IPR001675. Glyco_trans_29. IPR012163. Sialyl_trans. [Graphical view]
Pfam	PF00777. Glyco_transf_29. 1 hit. [Graphical view]
PIRSF	PIRSF005557. Sialyl_trans. 1 hit.
ProtoNet	Search...
Other
NextBio	20839561.

Entry information

Entry name

SIAT9_PANTR

Accession

Primary (citable) accession number: Q6KB55

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program