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Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

ST3GAL5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

GO - Molecular functioni

  1. lactosylceramide alpha-2,3-sialyltransferase activity Source: UniProtKB

GO - Biological processi

  1. protein glycosylation Source: InterPro
  2. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
Alternative name(s):
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Ganglioside GM3 synthase
ST3Gal V
Short name:
ST3GalV
Sialyltransferase 9
Gene namesi
Name:ST3GAL5
Synonyms:SIAT9
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence Analysis
Transmembranei6 – 2621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini27 – 362336LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of Golgi membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Lactosylceramide alpha-2,3-sialyltransferasePRO_0000149304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi139 ↔ 297By similarity
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000057363.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257001.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ6KB55.
KOiK03370.
OMAiFFWKQVA.
OrthoDBiEOG76X609.
TreeFamiTF352819.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6KB55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRPSLLLKD ILKCTLLVFG VWILYILKLN YTTEECDMKK MHYVDPDRVK
60 70 80 90 100
RAQTYAQQVL QKECRPKFAK TSMALLFEHR YSVDLLPFVQ KAPKDSEAES
110 120 130 140 150
KYDPPFGFRK FSSKVQTLLE LLPEHDLPEH LKAKTCRRCV VIGSGGILHG
160 170 180 190 200
LELGHTLNQF DVVIRLNSAP VEGYSEHVGN KTTIRMTYPE GAPLSDLEYY
210 220 230 240 250
SNDLFVAVLF KSVDFNWLQA MVKNETLPFW VRLFFWKQVA EKIPLQPKHF
260 270 280 290 300
RILNPVIIKE TAFDILQYSE PQSRFWGRDK NVPTIGVIAV VLATHLCDEV
310 320 330 340 350
SLAGFGYDLS QPRTPLHYFD NQCMAAMNFQ TMHNVTTETK FLLKLVKEGV
360
VKDLSGGIDR EF
Length:362
Mass (Da):41,714
Last modified:July 4, 2004 - v1
Checksum:i4DD19605E1AB76AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ744807 mRNA. Translation: CAG32843.1.
RefSeqiNP_001032378.1. NM_001037301.1.
UniGeneiPtr.6348.

Genome annotation databases

EnsembliENSPTRT00000022576; ENSPTRP00000020834; ENSPTRG00000012146.
GeneIDi459371.
KEGGiptr:459371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ744807 mRNA. Translation: CAG32843.1.
RefSeqiNP_001032378.1. NM_001037301.1.
UniGeneiPtr.6348.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000057363.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPTRT00000022576; ENSPTRP00000020834; ENSPTRG00000012146.
GeneIDi459371.
KEGGiptr:459371.

Organism-specific databases

CTDi8869.

Phylogenomic databases

eggNOGiNOG257001.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ6KB55.
KOiK03370.
OMAiFFWKQVA.
OrthoDBiEOG76X609.
TreeFamiTF352819.

Miscellaneous databases

NextBioi20839561.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Phylogeny of sialyltransferases."
    Harduin-Lepers A., Martinez-Duncker I., Mollicone R., Delannoy P., Oriol R.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSIAT9_PANTR
AccessioniPrimary (citable) accession number: Q6KB55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 14, 2005
Last sequence update: July 4, 2004
Last modified: January 6, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.