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Q6KB55

- SIAT9_PANTR

UniProt

Q6KB55 - SIAT9_PANTR

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Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

ST3GAL5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

GO - Molecular functioni

  1. lactosylceramide alpha-2,3-sialyltransferase activity Source: UniProtKB

GO - Biological processi

  1. protein glycosylation Source: InterPro
  2. sialylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
Alternative name(s):
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
Ganglioside GM3 synthase
ST3Gal V
Short name:
ST3GalV
Sialyltransferase 9
Gene namesi
Name:ST3GAL5
Synonyms:SIAT9
OrganismiPan troglodytes (Chimpanzee)
Taxonomic identifieri9598 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
ProteomesiUP000002277: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicSequence Analysis
Transmembranei6 – 2621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini27 – 362336LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of Golgi membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Lactosylceramide alpha-2,3-sialyltransferasePRO_0000149304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi139 ↔ 297By similarity
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9598.ENSPTRP00000057363.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257001.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ6KB55.
KOiK03370.
OMAiFFWKQVA.
OrthoDBiEOG76X609.
TreeFamiTF352819.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6KB55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRPSLLLKD ILKCTLLVFG VWILYILKLN YTTEECDMKK MHYVDPDRVK
60 70 80 90 100
RAQTYAQQVL QKECRPKFAK TSMALLFEHR YSVDLLPFVQ KAPKDSEAES
110 120 130 140 150
KYDPPFGFRK FSSKVQTLLE LLPEHDLPEH LKAKTCRRCV VIGSGGILHG
160 170 180 190 200
LELGHTLNQF DVVIRLNSAP VEGYSEHVGN KTTIRMTYPE GAPLSDLEYY
210 220 230 240 250
SNDLFVAVLF KSVDFNWLQA MVKNETLPFW VRLFFWKQVA EKIPLQPKHF
260 270 280 290 300
RILNPVIIKE TAFDILQYSE PQSRFWGRDK NVPTIGVIAV VLATHLCDEV
310 320 330 340 350
SLAGFGYDLS QPRTPLHYFD NQCMAAMNFQ TMHNVTTETK FLLKLVKEGV
360
VKDLSGGIDR EF
Length:362
Mass (Da):41,714
Last modified:July 5, 2004 - v1
Checksum:i4DD19605E1AB76AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ744807 mRNA. Translation: CAG32843.1.
RefSeqiNP_001032378.1. NM_001037301.1.
UniGeneiPtr.6348.

Genome annotation databases

EnsembliENSPTRT00000022576; ENSPTRP00000020834; ENSPTRG00000012146.
GeneIDi459371.
KEGGiptr:459371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ744807 mRNA. Translation: CAG32843.1 .
RefSeqi NP_001032378.1. NM_001037301.1.
UniGenei Ptr.6348.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9598.ENSPTRP00000057363.

Protein family/group databases

CAZyi GT29. Glycosyltransferase Family 29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSPTRT00000022576 ; ENSPTRP00000020834 ; ENSPTRG00000012146 .
GeneIDi 459371.
KEGGi ptr:459371.

Organism-specific databases

CTDi 8869.

Phylogenomic databases

eggNOGi NOG257001.
GeneTreei ENSGT00760000119095.
HOGENOMi HOG000000682.
HOVERGENi HBG056676.
InParanoidi Q6KB55.
KOi K03370.
OMAi FFWKQVA.
OrthoDBi EOG76X609.
TreeFami TF352819.

Miscellaneous databases

NextBioi 20839561.

Family and domain databases

InterProi IPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view ]
Pfami PF00777. Glyco_transf_29. 1 hit.
[Graphical view ]
PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of sialyltransferases."
    Harduin-Lepers A., Martinez-Duncker I., Mollicone R., Delannoy P., Oriol R.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSIAT9_PANTR
AccessioniPrimary (citable) accession number: Q6KB55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3