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Q6KB55

- SIAT9_PANTR

UniProt

Q6KB55 - SIAT9_PANTR

Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

ST3GAL5

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).By similarity

    Catalytic activityi

    CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

    GO - Molecular functioni

    1. lactosylceramide alpha-2,3-sialyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. protein glycosylation Source: InterPro
    2. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
    Alternative name(s):
    CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
    Ganglioside GM3 synthase
    ST3Gal V
    Short name:
    ST3GalV
    Sialyltransferase 9
    Gene namesi
    Name:ST3GAL5
    Synonyms:SIAT9
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: InterPro

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Lactosylceramide alpha-2,3-sialyltransferasePRO_0000149304Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi30 – 301N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi139 ↔ 297By similarity
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9598.ENSPTRP00000057363.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 55CytoplasmicSequence Analysis
    Topological domaini27 – 362336LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257001.
    GeneTreeiENSGT00620000087815.
    HOGENOMiHOG000000682.
    HOVERGENiHBG056676.
    InParanoidiQ6KB55.
    KOiK03370.
    OMAiFFWKQVA.
    OrthoDBiEOG76X609.
    TreeFamiTF352819.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6KB55-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRPSLLLKD ILKCTLLVFG VWILYILKLN YTTEECDMKK MHYVDPDRVK    50
    RAQTYAQQVL QKECRPKFAK TSMALLFEHR YSVDLLPFVQ KAPKDSEAES 100
    KYDPPFGFRK FSSKVQTLLE LLPEHDLPEH LKAKTCRRCV VIGSGGILHG 150
    LELGHTLNQF DVVIRLNSAP VEGYSEHVGN KTTIRMTYPE GAPLSDLEYY 200
    SNDLFVAVLF KSVDFNWLQA MVKNETLPFW VRLFFWKQVA EKIPLQPKHF 250
    RILNPVIIKE TAFDILQYSE PQSRFWGRDK NVPTIGVIAV VLATHLCDEV 300
    SLAGFGYDLS QPRTPLHYFD NQCMAAMNFQ TMHNVTTETK FLLKLVKEGV 350
    VKDLSGGIDR EF 362
    Length:362
    Mass (Da):41,714
    Last modified:July 5, 2004 - v1
    Checksum:i4DD19605E1AB76AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ744807 mRNA. Translation: CAG32843.1.
    RefSeqiNP_001032378.1. NM_001037301.1.
    UniGeneiPtr.6348.

    Genome annotation databases

    EnsembliENSPTRT00000022576; ENSPTRP00000020834; ENSPTRG00000012146.
    GeneIDi459371.
    KEGGiptr:459371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ744807 mRNA. Translation: CAG32843.1 .
    RefSeqi NP_001032378.1. NM_001037301.1.
    UniGenei Ptr.6348.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9598.ENSPTRP00000057363.

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPTRT00000022576 ; ENSPTRP00000020834 ; ENSPTRG00000012146 .
    GeneIDi 459371.
    KEGGi ptr:459371.

    Organism-specific databases

    CTDi 8869.

    Phylogenomic databases

    eggNOGi NOG257001.
    GeneTreei ENSGT00620000087815.
    HOGENOMi HOG000000682.
    HOVERGENi HBG056676.
    InParanoidi Q6KB55.
    KOi K03370.
    OMAi FFWKQVA.
    OrthoDBi EOG76X609.
    TreeFami TF352819.

    Miscellaneous databases

    NextBioi 20839561.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Phylogeny of sialyltransferases."
      Harduin-Lepers A., Martinez-Duncker I., Mollicone R., Delannoy P., Oriol R.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSIAT9_PANTR
    AccessioniPrimary (citable) accession number: Q6KB55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3