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Protein

Autophagy-related protein 16-2

Gene

Atg16l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in autophagy.By similarity

GO - Biological processi

  • autophagosome assembly Source: GO_Central
  • negative stranded viral RNA replication Source: MGI
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 16-2
Alternative name(s):
APG16-like 2
Gene namesi
Name:Atg16l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1920933. Atg16l2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Autophagy-related protein 16-2PRO_0000337111Add
BLAST

Proteomic databases

EPDiQ6KAU8.
MaxQBiQ6KAU8.
PaxDbiQ6KAU8.
PRIDEiQ6KAU8.

PTM databases

iPTMnetiQ6KAU8.
PhosphoSiteiQ6KAU8.

Expressioni

Gene expression databases

BgeeiQ6KAU8.
ExpressionAtlasiQ6KAU8. baseline and differential.
GenevisibleiQ6KAU8. MM.

Interactioni

Protein-protein interaction databases

BioGridi216189. 1 interaction.
STRINGi10090.ENSMUSP00000112500.

Structurei

3D structure databases

ProteinModelPortaliQ6KAU8.
SMRiQ6KAU8. Positions 298-623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati338 – 37740WD 1Add
BLAST
Repeati382 – 42140WD 2Add
BLAST
Repeati424 – 45835WD 3Add
BLAST
Repeati459 – 50244WD 4Add
BLAST
Repeati504 – 54340WD 5Add
BLAST
Repeati550 – 58940WD 6Add
BLAST
Repeati593 – 62331WD 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 229114Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat ATG16 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IMNZ. Eukaryota.
ENOG410YFNR. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000112569.
HOVERGENiHBG050534.
InParanoidiQ6KAU8.
KOiK17890.
OMAiVTPATHQ.
OrthoDBiEOG70CR6M.
PhylomeDBiQ6KAU8.
TreeFamiTF315541.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR013923. Autophagy-rel_prot_16.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08614. ATG16. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6KAU8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGPGAPCDP CAPAAVWKRH IVRQLRHRDR TQKALFLELV PAYNHLLEKA
60 70 80 90 100
ELLAKFSEKL KSEPKDAIST RHEDWREEVS GTGPDQVSSP ASLRVKWQQE
110 120 130 140 150
KKGLQLVCGE MAYQVVKKSA ALDTLQSQLE ERQDRLEALQ ACVVQLQEAR
160 170 180 190 200
AQQSRQLEER QAENAAQREA YETLLQQAVH QEAALRRLQE EARDLLEQLV
210 220 230 240 250
QRKARAAAER NLRNERRERA NQALVSQELK KAAKRTVSIS EIPNTLEDGT
260 270 280 290 300
KEETVALAPA ALPEFSESET CEKWKRPFRS ASATSLTLSR CVDVVKGLLD
310 320 330 340 350
FKKRRGHSVG GAPEQRYQSI PVCVSAQIPS QAQDVLDAHL SEVNAVCFGP
360 370 380 390 400
NSSLLATGGA DRLIHLWNVV GGRLEANQTL EGAGGSITSV DFDPSGSQVL
410 420 430 440 450
AATYNQAAQL WKVGETQSKE TLSGHKDKVT AAKFKLTRHQ AVTGSRDRTV
460 470 480 490 500
KEWDLGRAYC SRTINVLSYC NDVVCGDHII ISGHNDQKIR FWDSRGPHCI
510 520 530 540 550
QVIPVQGRVT SLHLSYDQLH LLSCSRDNTL KVIDLRISNI RQVFRADGFK
560 570 580 590 600
CSSDWTKAVF SPDRSYALAG SSNGDLYIWD VNTGKLETSL QGPHCTAVNA
610 620
VAWCFSGNHV VSVDQGRKVV LWH
Length:623
Mass (Da):69,241
Last modified:May 20, 2008 - v2
Checksum:i0358F9B735BC44D6
GO
Isoform 2 (identifier: Q6KAU8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-403: GSQVLAAT → VRRLCPTA
     404-623: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):44,726
Checksum:i5F39D9A4CFCD26CB
GO

Sequence cautioni

The sequence AAH60054.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD21359.1 differs from that shown.The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei396 – 4038GSQVLAAT → VRRLCPTA in isoform 2. 1 PublicationVSP_033906
Alternative sequencei404 – 623220Missing in isoform 2. 1 PublicationVSP_033907Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131109 Transcribed RNA. Translation: BAD21359.1. Sequence problems.
AC107638 Genomic DNA. No translation available.
BC060054 mRNA. Translation: AAH60054.1. Different initiation.
CCDSiCCDS52329.1. [Q6KAU8-1]
RefSeqiNP_001104581.1. NM_001111111.1. [Q6KAU8-1]
UniGeneiMm.275744.

Genome annotation databases

EnsembliENSMUST00000120267; ENSMUSP00000112500; ENSMUSG00000047767. [Q6KAU8-1]
ENSMUST00000139609; ENSMUSP00000117387; ENSMUSG00000047767. [Q6KAU8-2]
ENSMUST00000143630; ENSMUSP00000117029; ENSMUSG00000047767. [Q6KAU8-2]
GeneIDi73683.
KEGGimmu:73683.
UCSCiuc009iof.2. mouse. [Q6KAU8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131109 Transcribed RNA. Translation: BAD21359.1. Sequence problems.
AC107638 Genomic DNA. No translation available.
BC060054 mRNA. Translation: AAH60054.1. Different initiation.
CCDSiCCDS52329.1. [Q6KAU8-1]
RefSeqiNP_001104581.1. NM_001111111.1. [Q6KAU8-1]
UniGeneiMm.275744.

3D structure databases

ProteinModelPortaliQ6KAU8.
SMRiQ6KAU8. Positions 298-623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216189. 1 interaction.
STRINGi10090.ENSMUSP00000112500.

PTM databases

iPTMnetiQ6KAU8.
PhosphoSiteiQ6KAU8.

Proteomic databases

EPDiQ6KAU8.
MaxQBiQ6KAU8.
PaxDbiQ6KAU8.
PRIDEiQ6KAU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120267; ENSMUSP00000112500; ENSMUSG00000047767. [Q6KAU8-1]
ENSMUST00000139609; ENSMUSP00000117387; ENSMUSG00000047767. [Q6KAU8-2]
ENSMUST00000143630; ENSMUSP00000117029; ENSMUSG00000047767. [Q6KAU8-2]
GeneIDi73683.
KEGGimmu:73683.
UCSCiuc009iof.2. mouse. [Q6KAU8-1]

Organism-specific databases

CTDi89849.
MGIiMGI:1920933. Atg16l2.

Phylogenomic databases

eggNOGiENOG410IMNZ. Eukaryota.
ENOG410YFNR. LUCA.
GeneTreeiENSGT00840000129769.
HOGENOMiHOG000112569.
HOVERGENiHBG050534.
InParanoidiQ6KAU8.
KOiK17890.
OMAiVTPATHQ.
OrthoDBiEOG70CR6M.
PhylomeDBiQ6KAU8.
TreeFamiTF315541.

Miscellaneous databases

PROiQ6KAU8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6KAU8.
ExpressionAtlasiQ6KAU8. baseline and differential.
GenevisibleiQ6KAU8. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR013923. Autophagy-rel_prot_16.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08614. ATG16. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiA16L2_MOUSE
AccessioniPrimary (citable) accession number: Q6KAU8
Secondary accession number(s): Q6PAU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: July 6, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.