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Protein

Exocyst complex component 3

Gene

Exoc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 3
Alternative name(s):
Exocyst complex component Sec6
Gene namesi
Name:Exoc3
Synonyms:Sec6l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2443972. Exoc3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 755755Exocyst complex component 3PRO_0000118926Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6KAR6.
PaxDbiQ6KAR6.
PRIDEiQ6KAR6.

PTM databases

iPTMnetiQ6KAR6.
PhosphoSiteiQ6KAR6.

Expressioni

Gene expression databases

BgeeiQ6KAR6.
CleanExiMM_EXOC3.
ExpressionAtlasiQ6KAR6. baseline and differential.
GenevisibleiQ6KAR6. MM.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1. Interacts with BIRC6/bruce (By similarity). Interacts with MYRIP.By similarity2 Publications

Protein-protein interaction databases

IntActiQ6KAR6. 6 interactions.
MINTiMINT-1897647.
STRINGi10090.ENSMUSP00000039416.

Structurei

3D structure databases

ProteinModelPortaliQ6KAR6.
SMRiQ6KAR6. Positions 389-723.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili34 – 6229Sequence analysisAdd
BLAST
Coiled coili618 – 64932Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
HOGENOMiHOG000043095.
HOVERGENiHBG034187.
InParanoidiQ6KAR6.
KOiK06110.
OMAiNIRDDAM.
OrthoDBiEOG7X9G69.
PhylomeDBiQ6KAR6.
TreeFamiTF314979.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6KAR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCKDSACFLT MKETDLEAVA TAVQRVAGML QRPDQLDKVE QYRRREARKK
60 70 80 90 100
ASVEARLKAA IQSQLDGVRT GLSQLHNALN DVKDIQQSLA DVSKDWRQSI
110 120 130 140 150
NTIESLKDVK DAVVQHSQLA AAVENLKNIF SVPEIVRETQ DLIEQGALLQ
160 170 180 190 200
AHRKLMDLEC SRDGLMCEQY RMDSGNKRDM TLIHGYFGST QGLSDELAKQ
210 220 230 240 250
LWMVLQRSLV TVRRDPTLLV SVVRIIEREE KIDRRILDRK KQTGFVPPGR
260 270 280 290 300
PKNWKEKMFA ILDRTVTTRI EGTQADTRES DKMWLVRHLE IIRKYVLDDL
310 320 330 340 350
IVAKNLMVQC FPPHYEIFKN LLSMYHQALS TRMQDLASED LEANEIVSLL
360 370 380 390 400
TWVLNTYTSA EMMGNVELAP EVDVSALEPL LSPNIVSELL DTYMSTLTSN
410 420 430 440 450
IIAWLRKALE TDKKDWSKET EPEADQDGYY QTTLPAIVFQ MFEQNLQVAA
460 470 480 490 500
QISEDLKTKV LVLCLQQMNS FLSRYKDEAQ LYKEEHLRNR QHPHCYVQYM
510 520 530 540 550
IAIINNCQTF KESIISLKRK YLKTEAEEGL CLSQPSMDGI LDAIAKEGCS
560 570 580 590 600
SLLEEVFLDL EQHLNELMTK KWLLGSNAVD IICVTVEDYF NDFAKIKKPY
610 620 630 640 650
KKRMTAEAHR RVVVEYLRAV MQKRISFRSA EERKEGAEKM VREAEQLRFL
660 670 680 690 700
FRKLASGFGE DADGHCDTIV AVAEVIKLTD PSLLYLEVST LVSKYPDIRD
710 720 730 740 750
DHIGALLALR GDASRDMKQT IMETLEQGPM QASPNYVPIF KEIVVPSLNV

AKLLK
Length:755
Mass (Da):86,455
Last modified:November 22, 2005 - v2
Checksum:i47B4D8AFAAC7CBCB
GO

Sequence cautioni

The sequence BAD21391.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131141 mRNA. Translation: BAD21391.1. Different initiation.
CCDSiCCDS26640.1.
RefSeqiNP_796307.2. NM_177333.3.
XP_006517254.1. XM_006517191.1.
UniGeneiMm.261859.

Genome annotation databases

EnsembliENSMUST00000035934; ENSMUSP00000039416; ENSMUSG00000034152.
GeneIDi211446.
KEGGimmu:211446.
UCSCiuc007reu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131141 mRNA. Translation: BAD21391.1. Different initiation.
CCDSiCCDS26640.1.
RefSeqiNP_796307.2. NM_177333.3.
XP_006517254.1. XM_006517191.1.
UniGeneiMm.261859.

3D structure databases

ProteinModelPortaliQ6KAR6.
SMRiQ6KAR6. Positions 389-723.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6KAR6. 6 interactions.
MINTiMINT-1897647.
STRINGi10090.ENSMUSP00000039416.

PTM databases

iPTMnetiQ6KAR6.
PhosphoSiteiQ6KAR6.

Proteomic databases

EPDiQ6KAR6.
PaxDbiQ6KAR6.
PRIDEiQ6KAR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035934; ENSMUSP00000039416; ENSMUSG00000034152.
GeneIDi211446.
KEGGimmu:211446.
UCSCiuc007reu.1. mouse.

Organism-specific databases

CTDi11336.
MGIiMGI:2443972. Exoc3.

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
HOGENOMiHOG000043095.
HOVERGENiHBG034187.
InParanoidiQ6KAR6.
KOiK06110.
OMAiNIRDDAM.
OrthoDBiEOG7X9G69.
PhylomeDBiQ6KAR6.
TreeFamiTF314979.

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiExoc3. mouse.
PROiQ6KAR6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6KAR6.
CleanExiMM_EXOC3.
ExpressionAtlasiQ6KAR6. baseline and differential.
GenevisibleiQ6KAR6. MM.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.
    DNA Res. 11:127-135(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. Cited for: INTERACTION WITH MYRIP.
  3. "Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion."
    Saito T., Shibasaki T., Seino S.
    Biomed. Res. 29:85-91(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EXOC3L1.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiEXOC3_MOUSE
AccessioniPrimary (citable) accession number: Q6KAR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.