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Protein

ZZ-type zinc finger-containing protein 3

Gene

Zzz3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi687 – 71024H-T-H motifPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri824 – 87451ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ZZ-type zinc finger-containing protein 3
Gene namesi
Name:Zzz3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1920453. Zzz3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • Ada2/Gcn5/Ada3 transcription activator complex Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910ZZ-type zinc finger-containing protein 3PRO_0000287496Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891PhosphoserineBy similarity
Modified residuei96 – 961PhosphoserineBy similarity
Modified residuei137 – 1371PhosphoserineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity
Modified residuei142 – 1421PhosphoserineBy similarity
Modified residuei401 – 4011N6-acetyllysineCombined sources
Modified residuei613 – 6131PhosphoserineBy similarity
Cross-linki654 – 654Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei708 – 7081N6-acetyllysineBy similarity
Cross-linki715 – 715Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6KAQ7.
MaxQBiQ6KAQ7.
PaxDbiQ6KAQ7.
PeptideAtlasiQ6KAQ7.
PRIDEiQ6KAQ7.

PTM databases

iPTMnetiQ6KAQ7.
PhosphoSiteiQ6KAQ7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039068.
CleanExiMM_ZZZ3.
ExpressionAtlasiQ6KAQ7. baseline and differential.
GenevisibleiQ6KAQ7. MM.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.By similarity

Protein-protein interaction databases

BioGridi224485. 2 interactions.
IntActiQ6KAQ7. 3 interactions.
MINTiMINT-7984874.
STRINGi10090.ENSMUSP00000101706.

Structurei

3D structure databases

ProteinModelPortaliQ6KAQ7.
SMRiQ6KAQ7. Positions 659-722, 814-882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini654 – 71461HTH myb-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH myb-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri824 – 87451ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHEM. Eukaryota.
ENOG410ZINA. LUCA.
GeneTreeiENSGT00390000005307.
HOGENOMiHOG000286030.
HOVERGENiHBG062668.
InParanoidiQ6KAQ7.
OMAiKLEDHKI.
OrthoDBiEOG091G0H07.
PhylomeDBiQ6KAQ7.
TreeFamiTF106396.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6KAQ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGTCHSMAA SRSTRVTRST VGLNGLDESF CGRTLRNRSI AHPEEISSHS
60 70 80 90 100
QVRSRSPKKR AEPVPTQKGT NNGRTSDVRQ QSARDSWVSP RKRRLSSSEK
110 120 130 140 150
DDLERQALES CERRQAEPAP PVFKNIKRCL RAEATNSSEE DSPVKPDKEP
160 170 180 190 200
GEHRRIVVDH DADFQGAKRA CRCLILDDCE KREVKKVNVS EEGPLNAAVV
210 220 230 240 250
EEITGYLTVN GVDDSDSAVI NCDDCQPDGN TKQNNPGSCV LQEESVAGDG
260 270 280 290 300
DSETQTSVFC GSRKEDSCID HFVPCTKSDV QVKLEDHKLV TACLPVERRN
310 320 330 340 350
QLTAESASGP VSEIQSSLRD SEEEVDVVGD SSASKEQCNE NSSNPLDTGS
360 370 380 390 400
ERMPVSGEPE LSSILDCVSA QMTSLSEPQE HRYTLRTSPR RAALARSSPT
410 420 430 440 450
KTTSPYRENG QLEETNLSPQ ETNTTVSDHV SESPTDPAEV PQDGKVLCCD
460 470 480 490 500
SENYGSEGLS KPPSEARVNI GHLPSAKESA SQHTAEEEDD DPDVYYFESD
510 520 530 540 550
HVALKHNKDY QRLLQTIAVL EAQRSQAVQD LESLGKHQRE ALKNPIGFVE
560 570 580 590 600
KLQKKADIGL PYPQRVVQLP EIMWDQYTNS LGNFEREFKH RKRHTRRVKL
610 620 630 640 650
VFDKVGLPAR PKSPLDPKKD GESLSYSMLP LSDGPEGSHN RPQMIRGRLC
660 670 680 690 700
DDSKPETFNQ LWTVEEQKKL EQLLLKYPPE EVESRRWQKI ADELGNRTAK
710 720 730 740 750
QVASRVQKYF IKLTKAGIPV PGRTPNLYIY SRKSSTSRRQ HPLNKHLFKP
760 770 780 790 800
STFMTSHEPP VYMDEDDDRS CLHSHMSTAA EEASDEESIP IIYRSLPEYK
810 820 830 840 850
ELLQFKKLKK QKLQQMQAES GFVQHVGFKC DNCGVEPIQG VRWHCQDCPP
860 870 880 890 900
EMSLDFCDSC SDCPHETDIH KEDHQLEPVY KSETFLDRDY CVSQGTSYSY
910
LDPNYFPANR
Length:910
Mass (Da):102,307
Last modified:May 15, 2007 - v2
Checksum:i2E67A6E0043CC79B
GO
Isoform 2 (identifier: Q6KAQ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-501: Missing.
     502-509: VALKHNKD → MIDLWLYS

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):47,606
Checksum:iC7DCF81FDAD02B01
GO
Isoform 3 (identifier: Q6KAQ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-496: Missing.
     497-509: FESDHVALKHNKD → MLGSEVLVQHFNS
     605-605: Missing.

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):47,927
Checksum:i826270ACE69F5FD6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 501501Missing in isoform 2. 1 PublicationVSP_025514Add
BLAST
Alternative sequencei1 – 496496Missing in isoform 3. 1 PublicationVSP_025515Add
BLAST
Alternative sequencei497 – 50913FESDH…KHNKD → MLGSEVLVQHFNS in isoform 3. 1 PublicationVSP_025516Add
BLAST
Alternative sequencei502 – 5098VALKHNKD → MIDLWLYS in isoform 2. 1 PublicationVSP_025517
Alternative sequencei605 – 6051Missing in isoform 3. 1 PublicationVSP_025518

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131150 mRNA. Translation: BAD21400.1.
AK132612 mRNA. Translation: BAE21262.1.
AK165882 mRNA. Translation: BAE38435.1.
CCDSiCCDS38674.1. [Q6KAQ7-1]
RefSeqiNP_001074224.1. NM_001080755.2. [Q6KAQ7-1]
XP_006500911.1. XM_006500848.2. [Q6KAQ7-1]
XP_006500913.1. XM_006500850.2. [Q6KAQ7-1]
XP_006500914.1. XM_006500851.2. [Q6KAQ7-1]
XP_006500919.1. XM_006500856.2. [Q6KAQ7-3]
XP_006500920.1. XM_006500857.2. [Q6KAQ7-2]
XP_006500921.1. XM_006500858.2. [Q6KAQ7-2]
UniGeneiMm.379292.

Genome annotation databases

EnsembliENSMUST00000106100; ENSMUSP00000101706; ENSMUSG00000039068. [Q6KAQ7-1]
ENSMUST00000106101; ENSMUSP00000101707; ENSMUSG00000039068. [Q6KAQ7-1]
ENSMUST00000106103; ENSMUSP00000101709; ENSMUSG00000039068. [Q6KAQ7-2]
ENSMUST00000200570; ENSMUSP00000143693; ENSMUSG00000039068. [Q6KAQ7-3]
GeneIDi108946.
KEGGimmu:108946.
UCSCiuc008rtm.1. mouse. [Q6KAQ7-2]
uc008rtn.2. mouse. [Q6KAQ7-1]
uc012czm.1. mouse. [Q6KAQ7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131150 mRNA. Translation: BAD21400.1.
AK132612 mRNA. Translation: BAE21262.1.
AK165882 mRNA. Translation: BAE38435.1.
CCDSiCCDS38674.1. [Q6KAQ7-1]
RefSeqiNP_001074224.1. NM_001080755.2. [Q6KAQ7-1]
XP_006500911.1. XM_006500848.2. [Q6KAQ7-1]
XP_006500913.1. XM_006500850.2. [Q6KAQ7-1]
XP_006500914.1. XM_006500851.2. [Q6KAQ7-1]
XP_006500919.1. XM_006500856.2. [Q6KAQ7-3]
XP_006500920.1. XM_006500857.2. [Q6KAQ7-2]
XP_006500921.1. XM_006500858.2. [Q6KAQ7-2]
UniGeneiMm.379292.

3D structure databases

ProteinModelPortaliQ6KAQ7.
SMRiQ6KAQ7. Positions 659-722, 814-882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi224485. 2 interactions.
IntActiQ6KAQ7. 3 interactions.
MINTiMINT-7984874.
STRINGi10090.ENSMUSP00000101706.

PTM databases

iPTMnetiQ6KAQ7.
PhosphoSiteiQ6KAQ7.

Proteomic databases

EPDiQ6KAQ7.
MaxQBiQ6KAQ7.
PaxDbiQ6KAQ7.
PeptideAtlasiQ6KAQ7.
PRIDEiQ6KAQ7.

Protocols and materials databases

DNASUi108946.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106100; ENSMUSP00000101706; ENSMUSG00000039068. [Q6KAQ7-1]
ENSMUST00000106101; ENSMUSP00000101707; ENSMUSG00000039068. [Q6KAQ7-1]
ENSMUST00000106103; ENSMUSP00000101709; ENSMUSG00000039068. [Q6KAQ7-2]
ENSMUST00000200570; ENSMUSP00000143693; ENSMUSG00000039068. [Q6KAQ7-3]
GeneIDi108946.
KEGGimmu:108946.
UCSCiuc008rtm.1. mouse. [Q6KAQ7-2]
uc008rtn.2. mouse. [Q6KAQ7-1]
uc012czm.1. mouse. [Q6KAQ7-3]

Organism-specific databases

CTDi26009.
MGIiMGI:1920453. Zzz3.

Phylogenomic databases

eggNOGiENOG410IHEM. Eukaryota.
ENOG410ZINA. LUCA.
GeneTreeiENSGT00390000005307.
HOGENOMiHOG000286030.
HOVERGENiHBG062668.
InParanoidiQ6KAQ7.
OMAiKLEDHKI.
OrthoDBiEOG091G0H07.
PhylomeDBiQ6KAQ7.
TreeFamiTF106396.

Miscellaneous databases

PROiQ6KAQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039068.
CleanExiMM_ZZZ3.
ExpressionAtlasiQ6KAQ7. baseline and differential.
GenevisibleiQ6KAQ7. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
SM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZZZ3_MOUSE
AccessioniPrimary (citable) accession number: Q6KAQ7
Secondary accession number(s): Q3TMK6, Q3V189
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: September 7, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.