Q6K7V6 (TOCC_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tocopherol cyclase, chloroplastic

Alternative name(s):
Vitamin E pathway gene 1 protein

Gene names

Name:	VTE1
Ordered Locus Names:	Os02g0276500, LOC_Os02g17650
ORF Names:	OsJ_06237, OSJNBa0055M07.5, P0017G06.29

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the synthesis of both tocopherols and tocotrienols (vitamin E), which presumably protect photosynthetic complexes from oxidative stress. Catalyzes the conversion of 2-methyl-6-phytyl-1,4-hydroquinone and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (DMPQ) to delta- and gamma-tocopherol respectively. Converts also 2,3-dimethyl-5-geranylgeranyl-1,4-hydroquinone (DMGQ) to gamma-tocotrienol By similarity. Ref.5
Pathway	Cofactor biosynthesis; tocopherol biosynthesis.
Subcellular location	Plastid › chloroplast › plastoglobule By similarity.
Tissue specificity	Expressed in the roots, stems, leaves and spikelets. Ref.5
Induction	By salt and drougt stresses, H2O2, salicylic acid (SA) and abscisic acid (ABA). Ref.5
Miscellaneous	Plants overexpressing VTE1 show increased tolerance to salt stress with reduced H2O2 levels. Plants silencing VTE1 show enhanced sensitivity to salt stress with increased H2O2 levels.
Sequence caution	The sequence BAD21817.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAD28674.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chlorophyll metabolic process Inferred from electronic annotation. Source: EnsemblPlants/Gramene fatty acid metabolic process Inferred from electronic annotation. Source: EnsemblPlants/Gramene phloem sucrose loading Inferred from electronic annotation. Source: EnsemblPlants/Gramene regulation of defense response Inferred from electronic annotation. Source: EnsemblPlants/Gramene response to high light intensity Inferred from electronic annotation. Source: EnsemblPlants/Gramene response to oxidative stress Inferred from mutant phenotype Ref.5. Source: UniProtKB response to salt stress Inferred from mutant phenotype Ref.5. Source: UniProtKB response to temperature stimulus Inferred from electronic annotation. Source: EnsemblPlants/Gramene vitamin E biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway xanthophyll metabolic process Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Cellular_component	plastoglobule Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	tocopherol cyclase activity Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 61	61	Chloroplast Potential
	Chain	62 – 470	409	Probable tocopherol cyclase, chloroplastic		PRO_0000409872

Sequences

	Sequence		Length	Mass (Da)
	Q6K7V6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0E354ED483BB3003	FASTA	470	52,195
	10 20 30 40 50 60 MDLAAAAVAV SFPRPAPPPR RCAPRRHRRA LAPRAASSSP SPSTAVAAPV YAPTPRDRAL 70 80 90 100 110 120 RTPHSGYHYD GTARPFFEGW YFKVSIPECR QSFCFMYSVE NPLFRDGMSD LDRVIHGSRF 130 140 150 160 170 180 TGVGAQILGA DDKYICQFTE KSNNFWGSRH ELMLGNTFIP NNGSTPPEGE VPPQEFSSRV 190 200 210 220 230 240 LEGFQVTPIW HQGFIRDDGR SKYVPNVQTA RWEYSTRPVY GWGDVTSKQK STAGWLAAFP 250 260 270 280 290 300 FFEPHWQICM AGGLSTGWIE WDGERFEFEN APSYSEKNWG AGFPRKWYWV QCNVFSGASG 310 320 330 340 350 360 EVALTAAGGL RKIGLGETYE SPSLIGIHYE GKFYEFVPWT GTVSWDIAPW GHWKLSGENK 370 380 390 400 410 420 NHLVEIEATT KEPGTALRAP TMEAGLVPAC KDTCYGDLRL QMWEKRNDGG KGKMILDATS 430 440 450 460 470 NMAALEVGGG PWFNGWKGTT VSNEIVNNVV GTQVDVESLF PIPFLKPPGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The map-based sequence of the rice genome." International rice genome sequencing project (IRGSP) Nature 436:793-800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The rice annotation project database (RAP-DB): 2008 update." The rice annotation project (RAP) Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: cv. Nipponbare.
[3]	"The genomes of Oryza sativa: a history of duplications." Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L. , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H. PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[4]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.
[5]	"The role of tocopherol cyclase in salt stress tolerance of rice (Oryza sativa)." Ouyang S., He S., Liu P., Zhang W., Zhang J., Chen S. Sci. China Life Sci. 54:181-188(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION. Strain: cv. Taipei 309.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP004770 Genomic DNA. Translation: BAD21816.1. AP004770 Genomic DNA. Translation: BAD21817.1. Sequence problems. AP005536 Genomic DNA. Translation: BAD28673.1. AP005536 Genomic DNA. Translation: BAD28674.1. Sequence problems. AP008208 Genomic DNA. Translation: BAF08459.1. CM000139 Genomic DNA. Translation: EEE56731.1. AK072052 mRNA. Translation: BAG92802.1.
RefSeq	NP_001046545.1. NM_001053080.1.
UniGene	Os.18701.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q6K7V6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os02g17650.1; LOC_Os02g17650.1; LOC_Os02g17650.
GeneID	4329007.
KEGG	osa:4329007.
Organism-specific databases
Gramene	Q6K7V6.
Phylogenomic databases
eggNOG	NOG05806.
HOGENOM	HOG000005813.
KO	K09834.
OMA	PHSGYHW.
ProtClustDB	PLN02818.
Enzyme and pathway databases
UniPathway	UPA00160.
Gene expression databases
ArrayExpress	Q6K7V6.
Family and domain databases
InterPro	IPR025893. Tocopherol_cyclase. [Graphical view]
Pfam	PF14249. Tocopherol_cycl. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TOCC_ORYSJ

Accession

Primary (citable) accession number: Q6K7V6
Secondary accession number(s): Q6K7V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program