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Q6K1J1

- UDB31_CANFA

UniProt

Q6K1J1 - UDB31_CANFA

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Protein
UDP-glucuronosyltransferase 2B31
Gene
UGT2B31
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 1154.
SABIO-RKQ6K1J1.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B31 (EC:2.4.1.17)
Short name:
UDPGT 2B31
Gene namesi
Name:UGT2B31
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 530506UDP-glucuronosyltransferase 2B31
PRO_0000036048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6K1J1.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000021111.

Structurei

3D structure databases

ProteinModelPortaliQ6K1J1.
SMRiQ6K1J1. Positions 286-447.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00640000091260.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
KOiK00699.
OMAiVIMEVIH.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6K1J1-1 [UniParc]FASTAAdd to Basket

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MSMKWISVLL GLQLSCYFSS GSCGKVLVWP TEYSHWINVK TILDELVQRG    50
HEVTVLTSSA SILVDPNKLS AIKFEIYSAH LSRGDFEAFF IKLLNILIYD 100
MPKDSFWTYF SLMQEFFWEF YECAQKLCKD VVLNKKLMTK LQESKFDLVL 150
ADTIIPCGEL LAELLKIPLV YSLRFSPGYA FEKHSGGLPL PPSYVPVILS 200
ELTDQMTFME RVKNMLYVLY FDFWFQTINE KSWDQFYSEV LGRPTTLYEL 250
MRKADIWLIR TYWDFEYPHP LLPHFDFVGG LHCKPAKSLP TEMEEFVQSS 300
GENGIVVFSL GSMVNNMTEE RANVIASALA QIPQKVLWRF DGKKPDTLGP 350
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ 400
ADNIVHMKAK GAAIRLDFST MSSADLLNAL RMVINDPSYK ENAMKLSGIH 450
HDQPIKPLDR AVFWIEYVMR HQGAKHLRPA SHDLTWFQYH SLDVIGFLLA 500
CVATAIFVTT QCCLFCCRKV AKTGKKIKKE 530
Length:530
Mass (Da):60,706
Last modified:July 5, 2004 - v1
Checksum:i50D8B26D1A962C2A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135176 mRNA. Translation: AAN10154.1.
RefSeqiNP_001003381.1. NM_001003381.1.
UniGeneiCfa.4508.

Genome annotation databases

EnsembliENSCAFT00000043645; ENSCAFP00000036792; ENSCAFG00000029232.
GeneIDi442984.
KEGGicfa:442984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY135176 mRNA. Translation: AAN10154.1 .
RefSeqi NP_001003381.1. NM_001003381.1.
UniGenei Cfa.4508.

3D structure databases

ProteinModelPortali Q6K1J1.
SMRi Q6K1J1. Positions 286-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000021111.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi Q6K1J1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000043645 ; ENSCAFP00000036792 ; ENSCAFG00000029232 .
GeneIDi 442984.
KEGGi cfa:442984.

Organism-specific databases

CTDi 442984.

Phylogenomic databases

eggNOGi COG1819.
GeneTreei ENSGT00640000091260.
HOGENOMi HOG000220831.
HOVERGENi HBG004033.
KOi K00699.
OMAi VIMEVIH.

Enzyme and pathway databases

BRENDAi 2.4.1.17. 1154.
SABIO-RK Q6K1J1.

Miscellaneous databases

NextBioi 20831655.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily."
    Soars M.G., Fettes M., O'Sullivan A.C., Riley R.J., Ethell B.T., Burchell B.
    Biochem. Pharmacol. 65:1251-1259(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Entry informationi

Entry nameiUDB31_CANFA
AccessioniPrimary (citable) accession number: Q6K1J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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