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Protein

UDP-glucuronosyltransferase 2B31

Gene

UGT2B31

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17. 1153.
SABIO-RKQ6K1J1.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B31 (EC:2.4.1.17)
Short name:
UDPGT 2B31
Gene namesi
Name:UGT2B31
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei495 – 51521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 530506UDP-glucuronosyltransferase 2B31PRO_0000036048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6K1J1.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000004177.

Structurei

3D structure databases

ProteinModelPortaliQ6K1J1.
SMRiQ6K1J1. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6K1J1.
KOiK00699.
OMAiIFVIMKC.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6K1J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKWISVLL GLQLSCYFSS GSCGKVLVWP TEYSHWINVK TILDELVQRG
60 70 80 90 100
HEVTVLTSSA SILVDPNKLS AIKFEIYSAH LSRGDFEAFF IKLLNILIYD
110 120 130 140 150
MPKDSFWTYF SLMQEFFWEF YECAQKLCKD VVLNKKLMTK LQESKFDLVL
160 170 180 190 200
ADTIIPCGEL LAELLKIPLV YSLRFSPGYA FEKHSGGLPL PPSYVPVILS
210 220 230 240 250
ELTDQMTFME RVKNMLYVLY FDFWFQTINE KSWDQFYSEV LGRPTTLYEL
260 270 280 290 300
MRKADIWLIR TYWDFEYPHP LLPHFDFVGG LHCKPAKSLP TEMEEFVQSS
310 320 330 340 350
GENGIVVFSL GSMVNNMTEE RANVIASALA QIPQKVLWRF DGKKPDTLGP
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
ADNIVHMKAK GAAIRLDFST MSSADLLNAL RMVINDPSYK ENAMKLSGIH
460 470 480 490 500
HDQPIKPLDR AVFWIEYVMR HQGAKHLRPA SHDLTWFQYH SLDVIGFLLA
510 520 530
CVATAIFVTT QCCLFCCRKV AKTGKKIKKE
Length:530
Mass (Da):60,706
Last modified:July 5, 2004 - v1
Checksum:i50D8B26D1A962C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135176 mRNA. Translation: AAN10154.1.
RefSeqiNP_001003381.1. NM_001003381.1.
UniGeneiCfa.4508.

Genome annotation databases

EnsembliENSCAFT00000043645; ENSCAFP00000036792; ENSCAFG00000029232.
GeneIDi442984.
KEGGicfa:442984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135176 mRNA. Translation: AAN10154.1.
RefSeqiNP_001003381.1. NM_001003381.1.
UniGeneiCfa.4508.

3D structure databases

ProteinModelPortaliQ6K1J1.
SMRiQ6K1J1. Positions 286-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000004177.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbiQ6K1J1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000043645; ENSCAFP00000036792; ENSCAFG00000029232.
GeneIDi442984.
KEGGicfa:442984.

Organism-specific databases

CTDi442984.

Phylogenomic databases

eggNOGiCOG1819.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220831.
HOVERGENiHBG004033.
InParanoidiQ6K1J1.
KOiK00699.
OMAiIFVIMKC.

Enzyme and pathway databases

BRENDAi2.4.1.17. 1153.
SABIO-RKQ6K1J1.

Miscellaneous databases

NextBioi20831655.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily."
    Soars M.G., Fettes M., O'Sullivan A.C., Riley R.J., Ethell B.T., Burchell B.
    Biochem. Pharmacol. 65:1251-1259(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Entry informationi

Entry nameiUDB31_CANFA
AccessioniPrimary (citable) accession number: Q6K1J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.