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Q6K1J1 (UDB31_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B31

Short name=UDPGT 2B31
EC=2.4.1.17
Gene names
Name:UGT2B31
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 530506UDP-glucuronosyltransferase 2B31
PRO_0000036048

Regions

Transmembrane495 – 51521Helical; Potential

Amino acid modifications

Glycosylation3161N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6K1J1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 50D8B26D1A962C2A

FASTA53060,706
        10         20         30         40         50         60 
MSMKWISVLL GLQLSCYFSS GSCGKVLVWP TEYSHWINVK TILDELVQRG HEVTVLTSSA 

        70         80         90        100        110        120 
SILVDPNKLS AIKFEIYSAH LSRGDFEAFF IKLLNILIYD MPKDSFWTYF SLMQEFFWEF 

       130        140        150        160        170        180 
YECAQKLCKD VVLNKKLMTK LQESKFDLVL ADTIIPCGEL LAELLKIPLV YSLRFSPGYA 

       190        200        210        220        230        240 
FEKHSGGLPL PPSYVPVILS ELTDQMTFME RVKNMLYVLY FDFWFQTINE KSWDQFYSEV 

       250        260        270        280        290        300 
LGRPTTLYEL MRKADIWLIR TYWDFEYPHP LLPHFDFVGG LHCKPAKSLP TEMEEFVQSS 

       310        320        330        340        350        360 
GENGIVVFSL GSMVNNMTEE RANVIASALA QIPQKVLWRF DGKKPDTLGP NTRLYKWLPQ 

       370        380        390        400        410        420 
NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ ADNIVHMKAK GAAIRLDFST 

       430        440        450        460        470        480 
MSSADLLNAL RMVINDPSYK ENAMKLSGIH HDQPIKPLDR AVFWIEYVMR HQGAKHLRPA 

       490        500        510        520        530 
SHDLTWFQYH SLDVIGFLLA CVATAIFVTT QCCLFCCRKV AKTGKKIKKE 

« Hide

References

[1]"Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily."
Soars M.G., Fettes M., O'Sullivan A.C., Riley R.J., Ethell B.T., Burchell B.
Biochem. Pharmacol. 65:1251-1259(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY135176 mRNA. Translation: AAN10154.1.
RefSeqNP_001003381.1. NM_001003381.1.
UniGeneCfa.4508.

3D structure databases

ProteinModelPortalQ6K1J1.
SMRQ6K1J1. Positions 286-447.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000021111.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbQ6K1J1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000043645; ENSCAFP00000036792; ENSCAFG00000029232.
GeneID442984.
KEGGcfa:442984.

Organism-specific databases

CTD442984.

Phylogenomic databases

eggNOGCOG1819.
GeneTreeENSGT00640000091260.
HOGENOMHOG000220831.
HOVERGENHBG004033.
KOK00699.
OMAVIMEVIH.

Enzyme and pathway databases

BRENDA2.4.1.17. 1154.
SABIO-RKQ6K1J1.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20831655.

Entry information

Entry nameUDB31_CANFA
AccessionPrimary (citable) accession number: Q6K1J1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families