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Q6K1J1

- UDB31_CANFA

UniProt

Q6K1J1 - UDB31_CANFA

Protein

UDP-glucuronosyltransferase 2B31

Gene

UGT2B31

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 1154.
    SABIO-RKQ6K1J1.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B31 (EC:2.4.1.17)
    Short name:
    UDPGT 2B31
    Gene namesi
    Name:UGT2B31
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 530506UDP-glucuronosyltransferase 2B31PRO_0000036048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6K1J1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000021111.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6K1J1.
    SMRiQ6K1J1. Positions 286-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei495 – 51521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00640000091260.
    HOGENOMiHOG000220831.
    HOVERGENiHBG004033.
    KOiK00699.
    OMAiVIMEVIH.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6K1J1-1 [UniParc]FASTAAdd to Basket

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    MSMKWISVLL GLQLSCYFSS GSCGKVLVWP TEYSHWINVK TILDELVQRG    50
    HEVTVLTSSA SILVDPNKLS AIKFEIYSAH LSRGDFEAFF IKLLNILIYD 100
    MPKDSFWTYF SLMQEFFWEF YECAQKLCKD VVLNKKLMTK LQESKFDLVL 150
    ADTIIPCGEL LAELLKIPLV YSLRFSPGYA FEKHSGGLPL PPSYVPVILS 200
    ELTDQMTFME RVKNMLYVLY FDFWFQTINE KSWDQFYSEV LGRPTTLYEL 250
    MRKADIWLIR TYWDFEYPHP LLPHFDFVGG LHCKPAKSLP TEMEEFVQSS 300
    GENGIVVFSL GSMVNNMTEE RANVIASALA QIPQKVLWRF DGKKPDTLGP 350
    NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ 400
    ADNIVHMKAK GAAIRLDFST MSSADLLNAL RMVINDPSYK ENAMKLSGIH 450
    HDQPIKPLDR AVFWIEYVMR HQGAKHLRPA SHDLTWFQYH SLDVIGFLLA 500
    CVATAIFVTT QCCLFCCRKV AKTGKKIKKE 530
    Length:530
    Mass (Da):60,706
    Last modified:July 5, 2004 - v1
    Checksum:i50D8B26D1A962C2A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135176 mRNA. Translation: AAN10154.1.
    RefSeqiNP_001003381.1. NM_001003381.1.
    UniGeneiCfa.4508.

    Genome annotation databases

    EnsembliENSCAFT00000043645; ENSCAFP00000036792; ENSCAFG00000029232.
    GeneIDi442984.
    KEGGicfa:442984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135176 mRNA. Translation: AAN10154.1 .
    RefSeqi NP_001003381.1. NM_001003381.1.
    UniGenei Cfa.4508.

    3D structure databases

    ProteinModelPortali Q6K1J1.
    SMRi Q6K1J1. Positions 286-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000021111.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi Q6K1J1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000043645 ; ENSCAFP00000036792 ; ENSCAFG00000029232 .
    GeneIDi 442984.
    KEGGi cfa:442984.

    Organism-specific databases

    CTDi 442984.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00640000091260.
    HOGENOMi HOG000220831.
    HOVERGENi HBG004033.
    KOi K00699.
    OMAi VIMEVIH.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 1154.
    SABIO-RK Q6K1J1.

    Miscellaneous databases

    NextBioi 20831655.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily."
      Soars M.G., Fettes M., O'Sullivan A.C., Riley R.J., Ethell B.T., Burchell B.
      Biochem. Pharmacol. 65:1251-1259(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

    Entry informationi

    Entry nameiUDB31_CANFA
    AccessioniPrimary (citable) accession number: Q6K1J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3