Reviewed, UniProtKB/Swiss-Prot Q6K1J1 (UDB31_CANFA)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B31
      Short name=UDPGT 2B31
    EC=2.4.1.17

Gene names

Name:

UGT2B31

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein Potential. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 530	506	UDP-glucuronosyltransferase 2B31		PRO_0000036048
Regions
	Transmembrane	495 – 515	21	Potential
Amino acid modifications
	Glycosylation	316	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6K1J1-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 50D8B26D1A962C2A	FASTA	530	60,706
	10 20 30 40 50 60 MSMKWISVLL GLQLSCYFSS GSCGKVLVWP TEYSHWINVK TILDELVQRG HEVTVLTSSA 70 80 90 100 110 120 SILVDPNKLS AIKFEIYSAH LSRGDFEAFF IKLLNILIYD MPKDSFWTYF SLMQEFFWEF 130 140 150 160 170 180 YECAQKLCKD VVLNKKLMTK LQESKFDLVL ADTIIPCGEL LAELLKIPLV YSLRFSPGYA 190 200 210 220 230 240 FEKHSGGLPL PPSYVPVILS ELTDQMTFME RVKNMLYVLY FDFWFQTINE KSWDQFYSEV 250 260 270 280 290 300 LGRPTTLYEL MRKADIWLIR TYWDFEYPHP LLPHFDFVGG LHCKPAKSLP TEMEEFVQSS 310 320 330 340 350 360 GENGIVVFSL GSMVNNMTEE RANVIASALA QIPQKVLWRF DGKKPDTLGP NTRLYKWLPQ 370 380 390 400 410 420 NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ ADNIVHMKAK GAAIRLDFST 430 440 450 460 470 480 MSSADLLNAL RMVINDPSYK ENAMKLSGIH HDQPIKPLDR AVFWIEYVMR HQGAKHLRPA 490 500 510 520 530 SHDLTWFQYH SLDVIGFLLA CVATAIFVTT QCCLFCCRKV AKTGKKIKKE

References

[1]

"Cloning and characterisation of the first drug-metabolising canine UDP-glucuronosyltransferase of the 2B subfamily." Soars M.G., Fettes M., O'Sullivan A.C., Riley R.J., Ethell B.T., Burchell B. Biochem. Pharmacol. 65:1251-1259(2003) [PubMed: 12694866] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY135176 mRNA. Translation: AAN10154.1.
RefSeq	NP_001003381.1.
UniGene	Cfa.4508
3D structure databases
SMR	Q6K1J1. Positions 286-447.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Genome annotation databases
Ensembl	ENSCAFG00000025306. Canis familiaris. [Contig view]
GeneID	442984.
KEGG	cfa:442984.
Phylogenomic databases
HOVERGEN	Q6K1J1.
Enzyme and pathway databases
BRENDA	2.4.1.17. 463.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB31_CANFA

Accession

Primary (citable) accession number: Q6K1J1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)