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Protein

UDP-glucuronosyltransferase 2B31

Gene

UGT2B31

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 1153
ReactomeiR-CFA-156588 Glucuronidation
SABIO-RKiQ6K1J1

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B31 (EC:2.4.1.17)
Short name:
UDPGT 2B31
Gene namesi
Name:UGT2B31
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003604825 – 530UDP-glucuronosyltransferase 2B31Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136N6-succinyllysineBy similarity1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6K1J1

Expressioni

Gene expression databases

BgeeiENSCAFG00000029232

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000004177

Structurei

3D structure databases

ProteinModelPortaliQ6K1J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiQ6K1J1
KOiK00699
OMAiRPYMPRV

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6K1J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKWISVLL GLQLSCYFSS GSCGKVLVWP TEYSHWINVK TILDELVQRG
60 70 80 90 100
HEVTVLTSSA SILVDPNKLS AIKFEIYSAH LSRGDFEAFF IKLLNILIYD
110 120 130 140 150
MPKDSFWTYF SLMQEFFWEF YECAQKLCKD VVLNKKLMTK LQESKFDLVL
160 170 180 190 200
ADTIIPCGEL LAELLKIPLV YSLRFSPGYA FEKHSGGLPL PPSYVPVILS
210 220 230 240 250
ELTDQMTFME RVKNMLYVLY FDFWFQTINE KSWDQFYSEV LGRPTTLYEL
260 270 280 290 300
MRKADIWLIR TYWDFEYPHP LLPHFDFVGG LHCKPAKSLP TEMEEFVQSS
310 320 330 340 350
GENGIVVFSL GSMVNNMTEE RANVIASALA QIPQKVLWRF DGKKPDTLGP
360 370 380 390 400
NTRLYKWLPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGIP MVGIPLFADQ
410 420 430 440 450
ADNIVHMKAK GAAIRLDFST MSSADLLNAL RMVINDPSYK ENAMKLSGIH
460 470 480 490 500
HDQPIKPLDR AVFWIEYVMR HQGAKHLRPA SHDLTWFQYH SLDVIGFLLA
510 520 530
CVATAIFVTT QCCLFCCRKV AKTGKKIKKE
Length:530
Mass (Da):60,706
Last modified:July 5, 2004 - v1
Checksum:i50D8B26D1A962C2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY135176 mRNA Translation: AAN10154.1
RefSeqiNP_001003381.1, NM_001003381.1
UniGeneiCfa.4508

Genome annotation databases

EnsembliENSCAFT00000043645; ENSCAFP00000036792; ENSCAFG00000029232
GeneIDi442984
KEGGicfa:442984

Similar proteinsi

Entry informationi

Entry nameiUDB31_CANLF
AccessioniPrimary (citable) accession number: Q6K1J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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