ID   CP1A1_ORYLA             Reviewed;         521 AA.
AC   Q6JZS3;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=Cytochrome P450 1A1;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIA1;
GN   Name=cyp1a1; Synonyms=cyp1a;
OS   Oryzias latipes (Medaka fish) (Japanese ricefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Atherinomorpha;
OC   Beloniformes; Adrianichthyidae; Oryziinae; Oryzias.
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15178024; DOI=10.1016/j.marenvres.2004.03.006;
RA   Kim I.-C., Kim Y.J., Yoon Y.-D., Kawamura S., Lee Y.-S., Lee J.-S.;
RT   "Cloning of cytochrome P450 1A (CYP1A) genes from the hermaphrodite
RT   fish Rivulus marmoratus and the Japanese medaka Oryzias latipes.";
RL   Mar. Environ. Res. 58:125-129(2004).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate
CC       monooxygenases. They oxidize a variety of structurally unrelated
CC       compounds, including steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY: RH + reduced flavoprotein + O(2) = ROH +
CC       oxidized flavoprotein + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein (By similarity). Microsome membrane; Peripheral
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY233000; AAP68769.1; -; Genomic_DNA.
DR   Ensembl; ENSORLG00000014421; Oryzias latipes.
DR   HOVERGEN; Q6JZS3; -.
DR   BRENDA; 1.14.14.1; 19130.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017973; Cyt_P450_C.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   PANTHER; PTHR19383:SF63; Cyt_P450_E_grp-I_CYP1; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01683; EP450ICYP1A.
DR   PRINTS; PR00385; P450.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase.
FT   CHAIN         1    521       Cytochrome P450 1A1.
FT                                /FTId=PRO_0000051644.
FT   METAL       463    463       Iron (heme axial ligand) (By similarity).
SQ   SEQUENCE   521 AA;  58887 MW;  E36092B9E9957AF3 CRC64;
     MALMVLPFIG PLSVLEGLIA LTTVCVVYLL LKHFNKEIPG GLRQLPGPTP LPIIGNLLKL
     GSKPYLSLTE MSKRFGDVFQ IQIGMRPVVV LSGNETVRQA LIKQGDDFSG RPDLYSFQFI
     NDGKSLAFST DQAGVWRARR KLAYSALRSF SSLEGSNAEY SCMLEEHICK ETEHLVKEIE
     KVMKTEGKFD PYRYIVVSVA NVICGMCFGR RYDHHDQELV GLVNLSEDFV QVTGSGNPAD
     FIPALRYLPS KAMKKFVEIN NRFQSFVQKI VNEHSATYDK DNIRDITDSL IDHCEDRKLD
     ENSNIQMSDE KVVGIVNDLF GAGFDTISTA LSWAVGYLVA YPDIEKGLFE EIKENIGLNR
     NPTISDRSNL PLTDAFILEI FRHSSFLPFT IPHCTTRDTS LNGYYIPKDT CVFINQWQIN
     HDPKLWQDPS SFNPDRFLSE DGSEVNRLDG EKVMVFGLGK RRCIGEVIAR NEVFLFLAIM
     IQKLCFEEMP GEPLDMTPEY GLTMKHKRCN VRASLRLKDG C
//