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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
Synonyms:cyp1a
OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
Taxonomic identifieri8090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
ProteomesiUP000001038: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytochrome P450 1A1PRO_0000051644Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8090.ENSORLP00000018073.

Structurei

3D structure databases

ProteinModelPortaliQ6JZS3.
SMRiQ6JZS3. Positions 38-510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ6JZS3.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6JZS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALMVLPFIG PLSVLEGLIA LTTVCVVYLL LKHFNKEIPG GLRQLPGPTP
60 70 80 90 100
LPIIGNLLKL GSKPYLSLTE MSKRFGDVFQ IQIGMRPVVV LSGNETVRQA
110 120 130 140 150
LIKQGDDFSG RPDLYSFQFI NDGKSLAFST DQAGVWRARR KLAYSALRSF
160 170 180 190 200
SSLEGSNAEY SCMLEEHICK ETEHLVKEIE KVMKTEGKFD PYRYIVVSVA
210 220 230 240 250
NVICGMCFGR RYDHHDQELV GLVNLSEDFV QVTGSGNPAD FIPALRYLPS
260 270 280 290 300
KAMKKFVEIN NRFQSFVQKI VNEHSATYDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENSNIQMSDE KVVGIVNDLF GAGFDTISTA LSWAVGYLVA YPDIEKGLFE
360 370 380 390 400
EIKENIGLNR NPTISDRSNL PLTDAFILEI FRHSSFLPFT IPHCTTRDTS
410 420 430 440 450
LNGYYIPKDT CVFINQWQIN HDPKLWQDPS SFNPDRFLSE DGSEVNRLDG
460 470 480 490 500
EKVMVFGLGK RRCIGEVIAR NEVFLFLAIM IQKLCFEEMP GEPLDMTPEY
510 520
GLTMKHKRCN VRASLRLKDG C
Length:521
Mass (Da):58,887
Last modified:July 5, 2004 - v1
Checksum:iE36092B9E9957AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233000 Genomic DNA. Translation: AAP68769.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY233000 Genomic DNA. Translation: AAP68769.1.

3D structure databases

ProteinModelPortaliQ6JZS3.
SMRiQ6JZS3. Positions 38-510.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8090.ENSORLP00000018073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ6JZS3.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of cytochrome P450 1A (CYP1A) genes from the hermaphrodite fish Rivulus marmoratus and the Japanese medaka Oryzias latipes."
    Kim I.-C., Kim Y.J., Yoon Y.-D., Kawamura S., Lee Y.-S., Lee J.-S.
    Mar. Environ. Res. 58:125-129(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP1A1_ORYLA
AccessioniPrimary (citable) accession number: Q6JZS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.