Reviewed, UniProtKB/Swiss-Prot Q6JZS3 (CP1A1_ORYLA)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A1
    EC=1.14.14.1
Alternative name(s):
    CYPIA1

Gene names

Name:	cyp1a1
Synonyms:	cyp1a

Organism

Oryzias latipes (Medaka fish) (Japanese ricefish)

Taxonomic identifier

8090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Acanthopterygii › Percomorpha › Atherinomorpha › Beloniformes › Adrianichthyidae › Oryziinae › Oryzias

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 521	521	Cytochrome P450 1A1		PRO_0000051644
Sites
	Metal binding	463	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6JZS3-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: E36092B9E9957AF3	FASTA	521	58,887
	10 20 30 40 50 60 MALMVLPFIG PLSVLEGLIA LTTVCVVYLL LKHFNKEIPG GLRQLPGPTP LPIIGNLLKL 70 80 90 100 110 120 GSKPYLSLTE MSKRFGDVFQ IQIGMRPVVV LSGNETVRQA LIKQGDDFSG RPDLYSFQFI 130 140 150 160 170 180 NDGKSLAFST DQAGVWRARR KLAYSALRSF SSLEGSNAEY SCMLEEHICK ETEHLVKEIE 190 200 210 220 230 240 KVMKTEGKFD PYRYIVVSVA NVICGMCFGR RYDHHDQELV GLVNLSEDFV QVTGSGNPAD 250 260 270 280 290 300 FIPALRYLPS KAMKKFVEIN NRFQSFVQKI VNEHSATYDK DNIRDITDSL IDHCEDRKLD 310 320 330 340 350 360 ENSNIQMSDE KVVGIVNDLF GAGFDTISTA LSWAVGYLVA YPDIEKGLFE EIKENIGLNR 370 380 390 400 410 420 NPTISDRSNL PLTDAFILEI FRHSSFLPFT IPHCTTRDTS LNGYYIPKDT CVFINQWQIN 430 440 450 460 470 480 HDPKLWQDPS SFNPDRFLSE DGSEVNRLDG EKVMVFGLGK RRCIGEVIAR NEVFLFLAIM 490 500 510 520 IQKLCFEEMP GEPLDMTPEY GLTMKHKRCN VRASLRLKDG C

References

[1]

"Cloning of cytochrome P450 1A (CYP1A) genes from the hermaphrodite fish Rivulus marmoratus and the Japanese medaka Oryzias latipes." Kim I.-C., Kim Y.J., Yoon Y.-D., Kawamura S., Lee Y.-S., Lee J.-S. Mar. Environ. Res. 58:125-129(2004) [PubMed: 15178024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY233000 Genomic DNA. Translation: AAP68769.1.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSORLG00000014421. Oryzias latipes. [Contig view]
Phylogenomic databases
HOVERGEN	Q6JZS3.
Enzyme and pathway databases
BRENDA	1.14.14.1. 19130.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_ORYLA

Accession

Primary (citable) accession number: Q6JZS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)