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Q6JZS3 (CP1A1_ORYLA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Cytochrome P450 1A1
PRO_0000051644

Sites

Metal binding4631Iron (heme axial ligand) By similarity
Binding site2291Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6JZS3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E36092B9E9957AF3

FASTA52158,887
        10         20         30         40         50         60 
MALMVLPFIG PLSVLEGLIA LTTVCVVYLL LKHFNKEIPG GLRQLPGPTP LPIIGNLLKL 

        70         80         90        100        110        120 
GSKPYLSLTE MSKRFGDVFQ IQIGMRPVVV LSGNETVRQA LIKQGDDFSG RPDLYSFQFI 

       130        140        150        160        170        180 
NDGKSLAFST DQAGVWRARR KLAYSALRSF SSLEGSNAEY SCMLEEHICK ETEHLVKEIE 

       190        200        210        220        230        240 
KVMKTEGKFD PYRYIVVSVA NVICGMCFGR RYDHHDQELV GLVNLSEDFV QVTGSGNPAD 

       250        260        270        280        290        300 
FIPALRYLPS KAMKKFVEIN NRFQSFVQKI VNEHSATYDK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENSNIQMSDE KVVGIVNDLF GAGFDTISTA LSWAVGYLVA YPDIEKGLFE EIKENIGLNR 

       370        380        390        400        410        420 
NPTISDRSNL PLTDAFILEI FRHSSFLPFT IPHCTTRDTS LNGYYIPKDT CVFINQWQIN 

       430        440        450        460        470        480 
HDPKLWQDPS SFNPDRFLSE DGSEVNRLDG EKVMVFGLGK RRCIGEVIAR NEVFLFLAIM 

       490        500        510        520 
IQKLCFEEMP GEPLDMTPEY GLTMKHKRCN VRASLRLKDG C 

« Hide

References

[1]"Cloning of cytochrome P450 1A (CYP1A) genes from the hermaphrodite fish Rivulus marmoratus and the Japanese medaka Oryzias latipes."
Kim I.-C., Kim Y.J., Yoon Y.-D., Kawamura S., Lee Y.-S., Lee J.-S.
Mar. Environ. Res. 58:125-129(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY233000 Genomic DNA. Translation: AAP68769.1.

3D structure databases

ProteinModelPortalQ6JZS3.
SMRQ6JZS3. Positions 38-510.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8090.ENSORLP00000018073.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036991.
HOVERGENHBG106944.
InParanoidQ6JZS3.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_ORYLA
AccessionPrimary (citable) accession number: Q6JZS3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: July 5, 2004
Last modified: December 11, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families