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Q6JZS3

- CP1A1_ORYLA

UniProt

Q6JZS3 - CP1A1_ORYLA

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Oryzias latipes (Medaka fish) (Japanese ricefish)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei229 – 2291SubstrateBy similarity
    Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    Synonyms:cyp1a
    OrganismiOryzias latipes (Medaka fish) (Japanese ricefish)
    Taxonomic identifieri8090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeBeloniformesAdrianichthyidaeOryziinaeOryzias
    ProteomesiUP000001038: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1PRO_0000051644Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi8090.ENSORLP00000018073.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6JZS3.
    SMRiQ6JZS3. Positions 38-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG106944.
    InParanoidiQ6JZS3.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6JZS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALMVLPFIG PLSVLEGLIA LTTVCVVYLL LKHFNKEIPG GLRQLPGPTP    50
    LPIIGNLLKL GSKPYLSLTE MSKRFGDVFQ IQIGMRPVVV LSGNETVRQA 100
    LIKQGDDFSG RPDLYSFQFI NDGKSLAFST DQAGVWRARR KLAYSALRSF 150
    SSLEGSNAEY SCMLEEHICK ETEHLVKEIE KVMKTEGKFD PYRYIVVSVA 200
    NVICGMCFGR RYDHHDQELV GLVNLSEDFV QVTGSGNPAD FIPALRYLPS 250
    KAMKKFVEIN NRFQSFVQKI VNEHSATYDK DNIRDITDSL IDHCEDRKLD 300
    ENSNIQMSDE KVVGIVNDLF GAGFDTISTA LSWAVGYLVA YPDIEKGLFE 350
    EIKENIGLNR NPTISDRSNL PLTDAFILEI FRHSSFLPFT IPHCTTRDTS 400
    LNGYYIPKDT CVFINQWQIN HDPKLWQDPS SFNPDRFLSE DGSEVNRLDG 450
    EKVMVFGLGK RRCIGEVIAR NEVFLFLAIM IQKLCFEEMP GEPLDMTPEY 500
    GLTMKHKRCN VRASLRLKDG C 521
    Length:521
    Mass (Da):58,887
    Last modified:July 5, 2004 - v1
    Checksum:iE36092B9E9957AF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233000 Genomic DNA. Translation: AAP68769.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY233000 Genomic DNA. Translation: AAP68769.1 .

    3D structure databases

    ProteinModelPortali Q6JZS3.
    SMRi Q6JZS3. Positions 38-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8090.ENSORLP00000018073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG106944.
    InParanoidi Q6JZS3.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cytochrome P450 1A (CYP1A) genes from the hermaphrodite fish Rivulus marmoratus and the Japanese medaka Oryzias latipes."
      Kim I.-C., Kim Y.J., Yoon Y.-D., Kawamura S., Lee Y.-S., Lee J.-S.
      Mar. Environ. Res. 58:125-129(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCP1A1_ORYLA
    AccessioniPrimary (citable) accession number: Q6JZS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3