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Protein

Putative sodium-coupled neutral amino acid transporter 7

Gene

Slc38a7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 7
Alternative name(s):
Solute carrier family 38 member 7
Gene namesi
Name:Slc38a7
Synonyms:Snat7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1303268. Slc38a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence analysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Putative sodium-coupled neutral amino acid transporter 7PRO_0000319600Add
BLAST

Proteomic databases

PaxDbiQ6JWR2.
PRIDEiQ6JWR2.

Expressioni

Gene expression databases

GenevisibleiQ6JWR2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058216.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00710000106751.
HOGENOMiHOG000008036.
HOVERGENiHBG055999.
InParanoidiQ6JWR2.
KOiK14994.
OMAiSWVAVFN.
OrthoDBiEOG769ZJG.
PhylomeDBiQ6JWR2.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6JWR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVSINSDY SEWGSSTDAG ERARLLQSPC VDVVPKREGE ASPGDPDSGT
60 70 80 90 100
TSTLGAVFIV VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL
110 120 130 140 150
VILAYCSQAS NERTYQEVVW AVCGKLTGVL CEIAIAVYTF GTCIAFLIII
160 170 180 190 200
GDQQDKIIAV MAKEPDGASG SPWYTDRKFT ISLTAFLFIL PLSIPKEIGF
210 220 230 240 250
QKYASSLSVV GTWYVTAIVI IKYIWPDKEM RPGDILTRPA SWMAVFNAMP
260 270 280 290 300
TICFGFQCHV SSVPVFNSMR QPQVKTWGGV VTAAMVIALA VYMGTGICGF
310 320 330 340 350
LTFGAAVDPD VLRSYPSEDV AVAVARAFII LSVLTSYPIL HFCGRAVVEG
360 370 380 390 400
LWLRYKGTPV EEDVGRERRR RVLQTLVWFL LTLLLALFIP DIGKVISVIG
410 420 430 440 450
GLAACFIFIF PGLCLIQAKL SEMEEVKPAS WWALVSYGVL LVTLGAFIFG
460
QTTANAVFVD LLA
Length:463
Mass (Da):49,846
Last modified:July 5, 2004 - v1
Checksum:i3BD84A2B323321AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY294328 mRNA. Translation: AAQ56180.1.
BC086369 mRNA. Translation: AAH86369.1.
RefSeqiNP_001003705.1. NM_001003705.2.
XP_006255129.1. XM_006255067.2.
UniGeneiRn.27294.

Genome annotation databases

EnsembliENSRNOT00000061498; ENSRNOP00000058216; ENSRNOG00000012007.
GeneIDi291840.
KEGGirno:291840.
UCSCiRGD:1303268. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY294328 mRNA. Translation: AAQ56180.1.
BC086369 mRNA. Translation: AAH86369.1.
RefSeqiNP_001003705.1. NM_001003705.2.
XP_006255129.1. XM_006255067.2.
UniGeneiRn.27294.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058216.

Proteomic databases

PaxDbiQ6JWR2.
PRIDEiQ6JWR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000061498; ENSRNOP00000058216; ENSRNOG00000012007.
GeneIDi291840.
KEGGirno:291840.
UCSCiRGD:1303268. rat.

Organism-specific databases

CTDi55238.
RGDi1303268. Slc38a7.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00710000106751.
HOGENOMiHOG000008036.
HOVERGENiHBG055999.
InParanoidiQ6JWR2.
KOiK14994.
OMAiSWVAVFN.
OrthoDBiEOG769ZJG.
PhylomeDBiQ6JWR2.
TreeFamiTF328787.

Miscellaneous databases

PROiQ6JWR2.

Gene expression databases

GenevisibleiQ6JWR2. RN.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel amino acid transporter expressed in glutamatergic neurons."
    Morris M., Varoqui H., Erickson J.D.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS38A7_RAT
AccessioniPrimary (citable) accession number: Q6JWR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.