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Protein

Epididymal-specific lipocalin-12

Gene

Lcn12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-MMU-804914. Transport of fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-12
Gene namesi
Name:Lcn12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924951. Lcn12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001792320 – 193Epididymal-specific lipocalin-12Add BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 193By similarity
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6JVL5.
PRIDEiQ6JVL5.

Expressioni

Tissue specificityi

Expressed in epididymis.1 Publication

Gene expression databases

BgeeiENSMUSG00000026943.
CleanExiMM_LCN12.
ExpressionAtlasiQ6JVL5. baseline and differential.
GenevisibleiQ6JVL5. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028312.

Structurei

3D structure databases

ProteinModelPortaliQ6JVL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYSG. Eukaryota.
ENOG4111567. LUCA.
GeneTreeiENSGT00530000063610.
HOGENOMiHOG000231660.
HOVERGENiHBG101410.
InParanoidiQ6JVL5.
OMAiPCGLWLW.
OrthoDBiEOG091G0ULM.
PhylomeDBiQ6JVL5.
TreeFamiTF336103.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR003087. LCN2/LCN12.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01275. NGELATINASE.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6JVL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPWWALWLI LTLPQILESQ ISAMSQGFPQ MTSFQSDQFQ GEWFVLGLAD
60 70 80 90 100
NTFRREHRAL LNFFTTLFEL KEKSQFQVTN SMTRGKHCNT WSYTLIPATK
110 120 130 140 150
PGQFTRDNRG SGPGADRENI QVIETDYITF ALVLSLRQTS SQNITRVSLL
160 170 180 190
GRNWRLSHKT IDKFICLTRT QNLTKDNFLF PDLSDWLPDP QVC
Length:193
Mass (Da):22,341
Last modified:July 5, 2004 - v1
Checksum:iE93C5586552702B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299493 mRNA. Translation: AAQ63836.1.
CCDSiCCDS15776.1.
RefSeqiNP_084234.1. NM_029958.1.
UniGeneiMm.99123.

Genome annotation databases

EnsembliENSMUST00000028312; ENSMUSP00000028312; ENSMUSG00000026943.
GeneIDi77701.
KEGGimmu:77701.
UCSCiuc008ish.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299493 mRNA. Translation: AAQ63836.1.
CCDSiCCDS15776.1.
RefSeqiNP_084234.1. NM_029958.1.
UniGeneiMm.99123.

3D structure databases

ProteinModelPortaliQ6JVL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028312.

Proteomic databases

PaxDbiQ6JVL5.
PRIDEiQ6JVL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028312; ENSMUSP00000028312; ENSMUSG00000026943.
GeneIDi77701.
KEGGimmu:77701.
UCSCiuc008ish.1. mouse.

Organism-specific databases

CTDi286256.
MGIiMGI:1924951. Lcn12.

Phylogenomic databases

eggNOGiENOG410IYSG. Eukaryota.
ENOG4111567. LUCA.
GeneTreeiENSGT00530000063610.
HOGENOMiHOG000231660.
HOVERGENiHBG101410.
InParanoidiQ6JVL5.
OMAiPCGLWLW.
OrthoDBiEOG091G0ULM.
PhylomeDBiQ6JVL5.
TreeFamiTF336103.

Enzyme and pathway databases

ReactomeiR-MMU-804914. Transport of fatty acids.

Miscellaneous databases

PROiQ6JVL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026943.
CleanExiMM_LCN12.
ExpressionAtlasiQ6JVL5. baseline and differential.
GenevisibleiQ6JVL5. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR003087. LCN2/LCN12.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01275. NGELATINASE.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLCN12_MOUSE
AccessioniPrimary (citable) accession number: Q6JVL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.