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Protein

Epididymal-specific lipocalin-8

Gene

LCN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-8
Gene namesi
Name:LCN8
Synonyms:LCN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:27038. LCN8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134958919.

Polymorphism and mutation databases

DMDMi62286816.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 175150Epididymal-specific lipocalin-8PRO_0000017916Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi79 ↔ 166By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6JVE9.
PRIDEiQ6JVE9.

PTM databases

PhosphoSiteiQ6JVE9.

Expressioni

Gene expression databases

BgeeiENSG00000204001.
CleanExiHS_LCN8.
GenevisibleiQ6JVE9. HS.

Organism-specific databases

HPAiHPA027491.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360753.

Structurei

3D structure databases

ProteinModelPortaliQ6JVE9.
SMRiQ6JVE9. Positions 34-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWUM. Eukaryota.
ENOG41119TH. LUCA.
GeneTreeiENSGT00440000034507.
HOGENOMiHOG000220901.
HOVERGENiHBG052317.
InParanoidiQ6JVE9.
OMAiVKVAYNS.
OrthoDBiEOG091G0QIJ.
PhylomeDBiQ6JVE9.
TreeFamiTF337931.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6JVE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGAAEALPT VTVTLVAGAV PPASGALTAH CIGGFWREVG VASDQSLVLT
60 70 80 90 100
APKRVEGLFL TLSGSNLTVK VAYNSSGSCE IEKIVGSEID STGKFAFPGH
110 120 130 140 150
REIHVLDTDY EGYAILRVSL MWRGRNFRVL KYFTRSLEDK DRLGFWKFRE
160 170
LTADTGLYLA ARPGRCAELL KEELI
Length:175
Mass (Da):19,080
Last modified:July 5, 2004 - v1
Checksum:i47501262CA6BD5F8
GO
Isoform 2 (identifier: Q6JVE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: MPGAAEALPTVTVTLVAGAVPPASGALTAHC → MEELDRQK

Show »
Length:152
Mass (Da):17,254
Checksum:iF2B47347F0A43433
GO

Sequence cautioni

The sequence CAI12677 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3131MPGAA…LTAHC → MEELDRQK in isoform 2. 1 PublicationVSP_040219Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301268 mRNA. Translation: AAQ81973.1.
AL355987 Genomic DNA. Translation: CAI12677.1. Sequence problems.
CH471090 Genomic DNA. Translation: EAW88265.1.
BC130465 mRNA. Translation: AAI30466.1.
BC132714 mRNA. Translation: AAI32715.1.
CCDSiCCDS35183.1. [Q6JVE9-2]
RefSeqiNP_848564.2. NM_178469.3. [Q6JVE9-2]
UniGeneiHs.323991.

Genome annotation databases

EnsembliENST00000371688; ENSP00000360753; ENSG00000204001. [Q6JVE9-2]
ENST00000612714; ENSP00000482512; ENSG00000204001. [Q6JVE9-1]
GeneIDi138307.
KEGGihsa:138307.
UCSCiuc004cjb.2. human. [Q6JVE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301268 mRNA. Translation: AAQ81973.1.
AL355987 Genomic DNA. Translation: CAI12677.1. Sequence problems.
CH471090 Genomic DNA. Translation: EAW88265.1.
BC130465 mRNA. Translation: AAI30466.1.
BC132714 mRNA. Translation: AAI32715.1.
CCDSiCCDS35183.1. [Q6JVE9-2]
RefSeqiNP_848564.2. NM_178469.3. [Q6JVE9-2]
UniGeneiHs.323991.

3D structure databases

ProteinModelPortaliQ6JVE9.
SMRiQ6JVE9. Positions 34-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360753.

PTM databases

PhosphoSiteiQ6JVE9.

Polymorphism and mutation databases

DMDMi62286816.

Proteomic databases

PaxDbiQ6JVE9.
PRIDEiQ6JVE9.

Protocols and materials databases

DNASUi138307.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371688; ENSP00000360753; ENSG00000204001. [Q6JVE9-2]
ENST00000612714; ENSP00000482512; ENSG00000204001. [Q6JVE9-1]
GeneIDi138307.
KEGGihsa:138307.
UCSCiuc004cjb.2. human. [Q6JVE9-1]

Organism-specific databases

CTDi138307.
GeneCardsiLCN8.
H-InvDBHIX0008556.
HGNCiHGNC:27038. LCN8.
HPAiHPA027491.
MIMi612902. gene.
neXtProtiNX_Q6JVE9.
PharmGKBiPA134958919.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWUM. Eukaryota.
ENOG41119TH. LUCA.
GeneTreeiENSGT00440000034507.
HOGENOMiHOG000220901.
HOVERGENiHBG052317.
InParanoidiQ6JVE9.
OMAiVKVAYNS.
OrthoDBiEOG091G0QIJ.
PhylomeDBiQ6JVE9.
TreeFamiTF337931.

Miscellaneous databases

GenomeRNAii138307.
PROiQ6JVE9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204001.
CleanExiHS_LCN8.
GenevisibleiQ6JVE9. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLCN8_HUMAN
AccessioniPrimary (citable) accession number: Q6JVE9
Secondary accession number(s): A1L4A8, A6NMN9, Q5T5R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.