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Protein

Epididymal-specific lipocalin-8

Gene

LCN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-8
Gene namesi
Name:LCN8
Synonyms:LCN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000204001.9
HGNCiHGNC:27038 LCN8
MIMi612902 gene
neXtProtiNX_Q6JVE9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204001
PharmGKBiPA134958919

Polymorphism and mutation databases

DMDMi62286816

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001791626 – 175Epididymal-specific lipocalin-8Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 166By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6JVE9
PeptideAtlasiQ6JVE9
PRIDEiQ6JVE9

PTM databases

iPTMnetiQ6JVE9
PhosphoSitePlusiQ6JVE9

Expressioni

Gene expression databases

BgeeiENSG00000204001
CleanExiHS_LCN8
GenevisibleiQ6JVE9 HS

Interactioni

Protein-protein interaction databases

BioGridi1265096 interactors.
STRINGi9606.ENSP00000360753

Structurei

3D structure databases

ProteinModelPortaliQ6JVE9
SMRiQ6JVE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWUM Eukaryota
ENOG41119TH LUCA
GeneTreeiENSGT00440000034507
HOGENOMiHOG000220901
HOVERGENiHBG052317
InParanoidiQ6JVE9
OMAiVKVAYNS
OrthoDBiEOG091G0QIJ
PhylomeDBiQ6JVE9
TreeFamiTF337931

Family and domain databases

Gene3Di2.40.128.201 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6JVE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGAAEALPT VTVTLVAGAV PPASGALTAH CIGGFWREVG VASDQSLVLT
60 70 80 90 100
APKRVEGLFL TLSGSNLTVK VAYNSSGSCE IEKIVGSEID STGKFAFPGH
110 120 130 140 150
REIHVLDTDY EGYAILRVSL MWRGRNFRVL KYFTRSLEDK DRLGFWKFRE
160 170
LTADTGLYLA ARPGRCAELL KEELI
Length:175
Mass (Da):19,080
Last modified:July 5, 2004 - v1
Checksum:i47501262CA6BD5F8
GO
Isoform 2 (identifier: Q6JVE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: MPGAAEALPTVTVTLVAGAVPPASGALTAHC → MEELDRQK

Show »
Length:152
Mass (Da):17,254
Checksum:iF2B47347F0A43433
GO

Sequence cautioni

The sequence CAI12677 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402191 – 31MPGAA…LTAHC → MEELDRQK in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301268 mRNA Translation: AAQ81973.1
AL355987 Genomic DNA Translation: CAI12677.1 Sequence problems.
CH471090 Genomic DNA Translation: EAW88265.1
BC130465 mRNA Translation: AAI30466.1
BC132714 mRNA Translation: AAI32715.1
CCDSiCCDS35183.1 [Q6JVE9-2]
RefSeqiNP_001332863.1, NM_001345934.1 [Q6JVE9-1]
NP_848564.2, NM_178469.3 [Q6JVE9-2]
UniGeneiHs.323991

Genome annotation databases

EnsembliENST00000371688; ENSP00000360753; ENSG00000204001 [Q6JVE9-2]
ENST00000612714; ENSP00000482512; ENSG00000204001 [Q6JVE9-1]
GeneIDi138307
KEGGihsa:138307
UCSCiuc004cjb.2 human [Q6JVE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLCN8_HUMAN
AccessioniPrimary (citable) accession number: Q6JVE9
Secondary accession number(s): A1L4A8, A6NMN9, Q5T5R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome