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Protein

Epididymal-specific lipocalin-12

Gene

LCN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-804914 Transport of fatty acids

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-12
Gene namesi
Name:LCN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000184925.11
HGNCiHGNC:28733 LCN12
MIMi612905 gene
neXtProtiNX_Q6JVE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184925
PharmGKBiPA134959347

Polymorphism and mutation databases

BioMutaiLCN12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001792220 – 192Epididymal-specific lipocalin-12Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi88 ↔ 192By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6JVE5
PRIDEiQ6JVE5
ProteomicsDBi66523

Expressioni

Gene expression databases

BgeeiENSG00000184925
CleanExiHS_LCN12
ExpressionAtlasiQ6JVE5 baseline and differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi130342, 1 interactor
IntActiQ6JVE5, 1 interactor
STRINGi9606.ENSP00000360696

Structurei

3D structure databases

ProteinModelPortaliQ6JVE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYSG Eukaryota
ENOG4111567 LUCA
GeneTreeiENSGT00530000063610
HOVERGENiHBG101410
InParanoidiQ6JVE5
OMAiEDQFQGE
OrthoDBiEOG091G0ULM
PhylomeDBiQ6JVE5
TreeFamiTF336103

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6JVE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLCGLWLW LSLLKVLQAQ TPTPLPLPPP MQSFQGNQFQ GEWFVLGLAG
60 70 80 90 100
NSFRPEHRAL LNAFTATFEL SDDGRFEVWN AMTRGQHCDT WSYVLIPAAQ
110 120 130 140 150
PGQFTVDHGV EPGADREETR VVDSDYTQFA LMLSRRHTSR LAVLRISLLG
160 170 180 190
RSWLLPPGTL DQFICLGRAQ GLSDDNIVFP DVTGWSPQAS VC
Length:192
Mass (Da):21,500
Last modified:July 5, 2004 - v1
Checksum:iF4681F87CCF7A230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301272 mRNA Translation: AAQ81977.1
AL807752 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88317.1
CCDSiCCDS7018.2
RefSeqiNP_848631.2, NM_178536.3
UniGeneiHs.440519

Genome annotation databases

EnsembliENST00000371633; ENSP00000360696; ENSG00000184925
GeneIDi286256
KEGGihsa:286256
UCSCiuc004ckb.4 human

Similar proteinsi

Entry informationi

Entry nameiLCN12_HUMAN
AccessioniPrimary (citable) accession number: Q6JVE5
Secondary accession number(s): A2AMJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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