Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Epididymal-specific lipocalin-12

Gene

LCN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal-specific lipocalin-12
Gene namesi
Name:LCN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28733. LCN12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959347.

Polymorphism and mutation databases

BioMutaiLCN12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 192173Epididymal-specific lipocalin-12PRO_0000017922Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi88 ↔ 192By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6JVE5.
PRIDEiQ6JVE5.

Expressioni

Gene expression databases

BgeeiQ6JVE5.
CleanExiHS_LCN12.
ExpressionAtlasiQ6JVE5. baseline and differential.

Organism-specific databases

HPAiHPA024680.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ6JVE5. 1 interaction.
STRINGi9606.ENSP00000360696.

Structurei

3D structure databases

ProteinModelPortaliQ6JVE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYSG. Eukaryota.
ENOG4111567. LUCA.
GeneTreeiENSGT00530000063610.
HOVERGENiHBG101410.
InParanoidiQ6JVE5.
OMAiPCGLWLW.
OrthoDBiEOG78M03G.
PhylomeDBiQ6JVE5.
TreeFamiTF336103.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01254. PGNDSYNTHASE.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6JVE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLCGLWLW LSLLKVLQAQ TPTPLPLPPP MQSFQGNQFQ GEWFVLGLAG
60 70 80 90 100
NSFRPEHRAL LNAFTATFEL SDDGRFEVWN AMTRGQHCDT WSYVLIPAAQ
110 120 130 140 150
PGQFTVDHGV EPGADREETR VVDSDYTQFA LMLSRRHTSR LAVLRISLLG
160 170 180 190
RSWLLPPGTL DQFICLGRAQ GLSDDNIVFP DVTGWSPQAS VC
Length:192
Mass (Da):21,500
Last modified:July 5, 2004 - v1
Checksum:iF4681F87CCF7A230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301272 mRNA. Translation: AAQ81977.1.
AL807752 Genomic DNA. Translation: CAM14423.1.
CH471090 Genomic DNA. Translation: EAW88317.1.
CCDSiCCDS7018.2.
RefSeqiNP_848631.2. NM_178536.3.
UniGeneiHs.440519.

Genome annotation databases

EnsembliENST00000371633; ENSP00000360696; ENSG00000184925.
GeneIDi286256.
KEGGihsa:286256.
UCSCiuc004ckb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY301272 mRNA. Translation: AAQ81977.1.
AL807752 Genomic DNA. Translation: CAM14423.1.
CH471090 Genomic DNA. Translation: EAW88317.1.
CCDSiCCDS7018.2.
RefSeqiNP_848631.2. NM_178536.3.
UniGeneiHs.440519.

3D structure databases

ProteinModelPortaliQ6JVE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6JVE5. 1 interaction.
STRINGi9606.ENSP00000360696.

Polymorphism and mutation databases

BioMutaiLCN12.

Proteomic databases

PaxDbiQ6JVE5.
PRIDEiQ6JVE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371633; ENSP00000360696; ENSG00000184925.
GeneIDi286256.
KEGGihsa:286256.
UCSCiuc004ckb.4. human.

Organism-specific databases

CTDi286256.
GeneCardsiLCN12.
HGNCiHGNC:28733. LCN12.
HPAiHPA024680.
MIMi612905. gene.
neXtProtiNX_Q6JVE5.
PharmGKBiPA134959347.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYSG. Eukaryota.
ENOG4111567. LUCA.
GeneTreeiENSGT00530000063610.
HOVERGENiHBG101410.
InParanoidiQ6JVE5.
OMAiPCGLWLW.
OrthoDBiEOG78M03G.
PhylomeDBiQ6JVE5.
TreeFamiTF336103.

Enzyme and pathway databases

ReactomeiR-HSA-804914. Transport of fatty acids.

Miscellaneous databases

GenomeRNAii286256.
PROiQ6JVE5.
SOURCEiSearch...

Gene expression databases

BgeeiQ6JVE5.
CleanExiHS_LCN12.
ExpressionAtlasiQ6JVE5. baseline and differential.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR01254. PGNDSYNTHASE.
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2."
    Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J., Orgebin-Crist M.-C.
    Gene 339:49-59(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLCN12_HUMAN
AccessioniPrimary (citable) accession number: Q6JVE5
Secondary accession number(s): A2AMJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.