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Protein

Prolactin receptor

Gene

PRLR

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for the anterior pituitary hormone prolactin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi211ZincBy similarity1
Metal bindingi212ZincBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SSC-1170546. Prolactin receptor signaling.
R-SSC-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin receptor
Short name:
PRL-R
Gene namesi
Name:PRLRImported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 16

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 237ExtracellularSequence analysisAdd BLAST213
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 625CytoplasmicSequence analysisAdd BLAST367

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001097925 – 625Prolactin receptorSequence analysisAdd BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 46By similarity
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi75 ↔ 86By similarity
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi132N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6JTA8.

Expressioni

Gene expression databases

BgeeiENSSSCG00000016830.
GenevisibleiQ6JTA8. SS.

Interactioni

Subunit structurei

Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028480.

Structurei

3D structure databases

ProteinModelPortaliQ6JTA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 128Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini129 – 229Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi215 – 219WSXWS motif5
Motifi267 – 275Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 114Poly-Ser4

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity
The box 1 motif is required for JAK interaction and/or activation.Curated

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUSW. Eukaryota.
ENOG410XRJS. LUCA.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000059569.
HOVERGENiHBG007314.
InParanoidiQ6JTA8.
KOiK05081.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
IPR033230. PRLR.
[Graphical view]
PANTHERiPTHR23036:SF86. PTHR23036:SF86. 1 hit.
PfamiPF09067. EpoR_lig-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6JTA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENVPSTVV FILLLFLNIS LLNGQSPPGK PEIFKCRSPE KETFTCWWKP
60 70 80 90 100
GADGGLPTNY TLTYHKEGET FTHECPDYKT GGPNSCYFNK KHTSIWTIYI
110 120 130 140 150
ITVNATNQMG SSSSDPRYVD VTYIVEPDPP VNLTLELKKP EDQKPYLWIK
160 170 180 190 200
WLPPTLVDVR SGWLTLQYEI RLQPEKTAEW ETHFAGQQTQ FKILSLYPGQ
210 220 230 240 250
KYLVQVRCKP DHGFWSEWSP ESSIQIPNDF SMKDTTMWIF VAILSAVVCL
260 270 280 290 300
IMIWAVALKG YSMVACILPP VPGPKIKGFD THLLEKGKSE ELLSALGCQD
310 320 330 340 350
FPPTSDCEDL LVEFLEVDDS EDQQLMPAHS KEHPSQGRKP THLDPDSDSG
360 370 380 390 400
RGSCDSPSLL SEKCDEPRAN PPKFHTPEGI EKPGDPETNL PRPQDPQSTS
410 420 430 440 450
VESKLLYFHA DGSKSSTWPL PQPPILHDPG SSYHNLADVG QLVLGTAGAT
460 470 480 490 500
AALLEKTDRH AFNPPKTTET GGEGRATEQK ESESFHSKTD QGTVWLLPQD
510 520 530 540 550
KGPFVSPKPM EYVEIHKVSK DGALALLPKQ QENGDRPEKA GAPETSKEYA
560 570 580 590 600
QVSRVMDNHI LVLVQDPRAR NVAPFEEPTK ETPPSRPQNP AAKDLASFTT
610 620
APGHCRHPLG GLDYLDPAGF MHSFQ
Length:625
Mass (Da):69,573
Last modified:September 13, 2004 - v2
Checksum:i751B2B593ABFC51B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti372P → R in AAQ76842 (Ref. 1) Curated1
Sequence conflicti406L → P in AAQ76842 (Ref. 1) Curated1
Sequence conflicti461A → G in AAQ76842 (Ref. 1) Curated1
Sequence conflicti480K → R in AAQ76842 (Ref. 1) Curated1
Sequence conflicti510M → L in AAQ76842 (Ref. 1) Curated1
Sequence conflicti534G → S in AAQ76842 (Ref. 1) Curated1
Sequence conflicti597S → G in AAQ76843 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY308824 mRNA. Translation: AAQ76841.1.
AY308825 mRNA. Translation: AAQ76842.1.
AY308826 mRNA. Translation: AAQ76843.1.
U96306 Genomic DNA. Translation: AAC02897.1.
RefSeqiNP_001001868.1. NM_001001868.1.
XP_013840184.1. XM_013984730.1.
UniGeneiSsc.27607.

Genome annotation databases

EnsembliENSSSCT00000018325; ENSSSCP00000017829; ENSSSCG00000016830.
GeneIDi414916.
KEGGissc:414916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY308824 mRNA. Translation: AAQ76841.1.
AY308825 mRNA. Translation: AAQ76842.1.
AY308826 mRNA. Translation: AAQ76843.1.
U96306 Genomic DNA. Translation: AAC02897.1.
RefSeqiNP_001001868.1. NM_001001868.1.
XP_013840184.1. XM_013984730.1.
UniGeneiSsc.27607.

3D structure databases

ProteinModelPortaliQ6JTA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028480.

Proteomic databases

PaxDbiQ6JTA8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000018325; ENSSSCP00000017829; ENSSSCG00000016830.
GeneIDi414916.
KEGGissc:414916.

Organism-specific databases

CTDi5618.

Phylogenomic databases

eggNOGiENOG410IUSW. Eukaryota.
ENOG410XRJS. LUCA.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000059569.
HOVERGENiHBG007314.
InParanoidiQ6JTA8.
KOiK05081.

Enzyme and pathway databases

ReactomeiR-SSC-1170546. Prolactin receptor signaling.
R-SSC-982772. Growth hormone receptor signaling.

Gene expression databases

BgeeiENSSSCG00000016830.
GenevisibleiQ6JTA8. SS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
IPR033230. PRLR.
[Graphical view]
PANTHERiPTHR23036:SF86. PTHR23036:SF86. 1 hit.
PfamiPF09067. EpoR_lig-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRLR_PIG
AccessioniPrimary (citable) accession number: Q6JTA8
Secondary accession number(s): O46679, Q6JTA9, Q6JTB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 13, 2004
Last modified: November 30, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.