ID   Q6JSD7_HUMAN            Unreviewed;        81 AA.
AC   Q6JSD7;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 87.
DE   RecName: Full=Aquaporin-1 {ECO:0000256|ARBA:ARBA00020966};
DE   AltName: Full=Aquaporin-CHIP {ECO:0000256|ARBA:ARBA00032182};
DE   AltName: Full=Water channel protein for red blood cells and kidney proximal tubule {ECO:0000256|ARBA:ARBA00031892};
DE   Flags: Fragment;
GN   Name=AQP1 {ECO:0000313|EMBL:AAR16186.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAR16186.1};
RN   [1] {ECO:0000313|EMBL:AAR16186.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Lung {ECO:0000313|EMBL:AAR16186.1};
RA   Polvi A., Ruosaari S., Vendelin J., West A., Saarikko I., Reinikainen A.,
RA   Hollmen J., Laitinen T., Mannila H., Lahesmaa R., Kere J.;
RT   "Transcriptional profiling of asthma candidate genes in 11 asthma related
RT   cell lines and lung tissue.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|ARBA:ARBA00006175}.
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DR   EMBL; AY312581; AAR16186.1; -; mRNA.
DR   AlphaFoldDB; Q6JSD7; -.
DR   PeptideAtlas; Q6JSD7; -.
DR   ChiTaRS; AQP1; human.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015250; F:water channel activity; IEA:UniProt.
DR   Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR023274; Aquaporin_1.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   PANTHER; PTHR19139; AQUAPORIN TRANSPORTER; 1.
DR   PANTHER; PTHR19139:SF161; AQUAPORIN-1; 1.
DR   Pfam; PF00230; MIP; 1.
DR   PRINTS; PR02013; AQUAPORIN1.
DR   SUPFAM; SSF81338; Aquaporin-like; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        22..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAR16186.1"
SQ   SEQUENCE   81 AA;  9056 MW;  3962857DA7D4F02F CRC64;
     CGINPARSFG SAVITHNFSN HWIFWVGPFI GGALAVLIYD FILAPRSSDL TDRVKVWTSG
     QVEEYDLDAD DINSRVEMKP K
//