Reviewed,
UniProtKB/Swiss-Prot Q6JQN1 (ACD10_HUMAN)
Last modified
November 24, 2009.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acyl-CoA dehydrogenase family member 10 Short name=ACAD-10 EC=1.3.99.- | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1059 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May function as oxidoreductase By similarity. |
| Cofactor | FAD By similarity. |
| Tissue specificity | Widely expressed with higher expression in liver, kidney, pancreas and spleen. Ref.1 |
| Sequence similarities | Belongs to the acyl-CoA dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: InterPro |
| Molecular function | FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activityInferred from electronic annotation. Source: InterPro hydrolase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6JQN1-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q6JQN1-2) The sequence of this isoform differs from the canonical sequence as follows: 883-890: GHGEVRFE → CFLPSFSL 891-1059: Missing. | ||||||
| Isoform 3 (identifier: Q6JQN1-3) The sequence of this isoform differs from the canonical sequence as follows: 1-398: Missing. 399-413: HSVDLQAVGLEDYGK → MLEYLSLTFLISVKI 883-890: GHGEVRFE → CFLPSFSL 891-1059: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 4 (identifier: Q6JQN1-4) The sequence of this isoform differs from the canonical sequence as follows: 285-285: P → L 286-1059: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1059 | 1059 | Acyl-CoA dehydrogenase family member 10 | PRO_0000284770 | |||||
Regions | |||||||||
| Nucleotide binding | 792 – 802 | 11 | FAD By similarity | ||||||
Sites | |||||||||
| Binding site | 828 | 1 | FAD By similarity | ||||||
| Binding site | 943 | 1 | FAD By similarity | ||||||
| Binding site | 1013 | 1 | FAD By similarity | ||||||
| Binding site | 1044 | 1 | FAD By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 398 | 398 | Missing in isoform 3. | VSP_024630 | |||||
| Alternative sequence | 285 | 1 | P → L in isoform 4. | VSP_024631 | |||||
| Alternative sequence | 286 – 1059 | 774 | Missing in isoform 4. | VSP_024632 | |||||
| Alternative sequence | 399 – 413 | 15 | HSVDL…EDYGK → MLEYLSLTFLISVKI in isoform 3. | VSP_024633 | |||||
| Alternative sequence | 883 – 890 | 8 | GHGEVRFE → CFLPSFSL in isoform 2 and isoform 3. | VSP_024634 | |||||
| Alternative sequence | 891 – 1059 | 169 | Missing in isoform 2 and isoform 3. | VSP_024635 | |||||
| Natural variant | 200 | 1 | Q → R: dbSNP rs35276160. | VAR_031811 | |||||
| Natural variant | 216 | 1 | T → P: dbSNP rs35753710. | VAR_031812 | |||||
| Natural variant | 463 | 1 | D → N: dbSNP rs36046440. | VAR_031813 | |||||
| Natural variant | 880 | 1 | A → V: dbSNP rs34245489. | VAR_031814 | |||||
Experimental info | |||||||||
| Sequence conflict | 124 | 1 | S → P in BAC03869. Ref.2 | ||||||
| Sequence conflict | 197 | 1 | C → M in BAC05046. Ref.2 | ||||||
| Sequence conflict | 663 | 1 | V → D in BAC03869. Ref.2 | ||||||
| Sequence conflict | 688 | 1 | H → R in BAC03869. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1." Ye X., Ji C., Zhou C., Zeng L., Gu S., Ying K., Xie Y., Mao Y. Mol. Biol. Rep. 31:191-195(2004) [PubMed: 15560374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Fetal brain. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Testis. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AY323912 mRNA. Translation: AAQ88260.1. AK092356 mRNA. Translation: BAC03869.1. AK097425 mRNA. Translation: BAC05046.1. BC015056 mRNA. Translation: AAH15056.1. Different initiation. BC126358 mRNA. Translation: AAI26359.1. | |
| IPI | IPI00418639. IPI00797832. IPI00843833. IPI00843880. |
| RefSeq | NP_001130010.1. NP_079523.3. |
| UniGene | Hs.331141 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1Z4O based on UniProtKB P71447. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6JQN1. |
Proteomic databases | |
| PRIDE | Q6JQN1. |
Genome annotation databases | |
| Ensembl | ENST00000313698; ENSP00000325137; ENSG00000111271; Homo sapiens. [Genome view] |
| GeneID | 80724. |
| KEGG | hsa:80724. |
| UCSC | uc001tso.2. human. uc001tsp.1. human. uc001tsq.1. human. |
Organism-specific databases | |
| CTD | 80724. |
| GeneCards | GC12P110586. |
| H-InvDB | HIX0011001. |
| HGNC | HGNC:21597. ACAD10. |
| MIM | 611181. gene. |
| PharmGKB | PA134976754. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q6JQN1. |
Gene expression databases | |
| ArrayExpress | Q6JQN1. |
| Bgee | Q6JQN1. |
| CleanEx | HS_ACAD10. |
| Genevestigator | Q6JQN1. |
Family and domain databases | |
| InterPro | IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. IPR013764. AcylCoA_oxidase/DH_1/2_C. IPR002575. APH_trans. IPR005834. Dehalogen-like_hydro. IPR006402. HAD-SF_hydro_IA_v3. IPR011945. HAD-SF_ppase_IA/epoxid_hydro_N. IPR005833. Haloacid_DH/epoxide_hydro. IPR011009. Kinase-like_dom. [Graphical view] |
| Gene3D | G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit. |
| Pfam | PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. PF01636. APH. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view] |
| PRINTS | PR00413. HADHALOGNASE. |
| TIGRFAMs | TIGR02247. HAD-1A3-hyp. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. |
| PROSITE | PS00072. ACYL_COA_DH_1. False negative. PS00073. ACYL_COA_DH_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 71031. |
| SOURCE | Search... |
Entry information
| Entry name | ACD10_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6JQN1 Secondary accession number(s): Q8N828, Q8NAP2, Q96BX5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


