Q6JQN1 (ACD10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA dehydrogenase family member 10
Short name=ACAD-10
EC=1.3.99.-

Gene names

Name:

ACAD10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1059 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA. Ref.4
Catalytic activity	Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
Cofactor	FAD By similarity.
Tissue specificity	Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and adult brain. Expression levels varying from isoform to isoform. Ref.1 Ref.4
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.
Sequence caution	The sequence AAH15056.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Non-traceable author statement Ref.4. Source: UniProtKB
Molecular function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro hydrolase activity Inferred from electronic annotation. Source: InterPro transferase activity, transferring phosphorus-containing groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6JQN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6JQN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     883-890: GHGEVRFE → CFLPSFSL
     891-1059: Missing.

Isoform 3 (identifier: Q6JQN1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-398: Missing.
     399-413: HSVDLQAVGLEDYGK → MLEYLSLTFLISVKI
     883-890: GHGEVRFE → CFLPSFSL
     891-1059: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6JQN1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     285-285: P → L
     286-1059: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1059	1059	Acyl-CoA dehydrogenase family member 10		PRO_0000284770
Regions
	Nucleotide binding	792 – 802	11	FAD By similarity
Sites
	Binding site	828	1	FAD By similarity
	Binding site	943	1	FAD By similarity
	Binding site	1013	1	FAD By similarity
	Binding site	1044	1	FAD By similarity
Natural variations
	Alternative sequence	1 – 398	398	Missing in isoform 3.		VSP_024630
	Alternative sequence	285	1	P → L in isoform 4.		VSP_024631
	Alternative sequence	286 – 1059	774	Missing in isoform 4.		VSP_024632
	Alternative sequence	399 – 413	15	HSVDL…EDYGK → MLEYLSLTFLISVKI in isoform 3.		VSP_024633
	Alternative sequence	883 – 890	8	GHGEVRFE → CFLPSFSL in isoform 2 and isoform 3.		VSP_024634
	Alternative sequence	891 – 1059	169	Missing in isoform 2 and isoform 3.		VSP_024635
	Natural variant	200	1	Q → R. Corresponds to variant rs35276160 [ dbSNP | Ensembl ].		VAR_031811
	Natural variant	216	1	T → P. Corresponds to variant rs35753710 [ dbSNP | Ensembl ].		VAR_031812
	Natural variant	463	1	D → N. Corresponds to variant rs36046440 [ dbSNP | Ensembl ].		VAR_031813
	Natural variant	880	1	A → V. Corresponds to variant rs34245489 [ dbSNP | Ensembl ].		VAR_031814
Experimental info
	Sequence conflict	124	1	S → P in BAC03869. Ref.2
	Sequence conflict	197	1	C → M in BAC05046. Ref.2
	Sequence conflict	663	1	V → D in BAC03869. Ref.2
	Sequence conflict	688	1	H → R in BAC03869. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B8D4376FCF73D746	FASTA	1,059	118,834
	10 20 30 40 50 60 MCVRSCFQSP RLQWVWRTAF LKHTQRRHQG SHRWTHLGGS TYRAVIFDMG GVLIPSPGRV 70 80 90 100 110 120 AAEWEVQNRI PSGTILKALM EGGENGPWMR FMRAEITAEG FLREFGRLCS EMLKTSVPVD 130 140 150 160 170 180 SFFSLLTSER VAKQFPVMTE AITQIRAKGL QTAVLSNNFY LPNQKSFLPL DRKQFDVIVE 190 200 210 220 230 240 SCMEGICKPD PRIYKLCLEQ LGLQPSESIF LDDLGTNLKE AARLGIHTIK VNDPETAVKE 250 260 270 280 290 300 LEALLGFTLR VGVPNTRPVK KTMEIPKDSL QKYLKDLLGI QTTGPLELLQ FDHGQSNPTY 310 320 330 340 350 360 YIRLANRDLV LRKKPPGTLL PSAHAIEREF RIMKALANAG VPVPNVLDLC EDSSVIGTPF 370 380 390 400 410 420 YVMEYCPGLI YKDPSLPGLE PSHRRAIYTA MNTVLCKIHS VDLQAVGLED YGKQGDYIPR 430 440 450 460 470 480 QVRTWVKQYR ASETSTIPAM ERLIEWLPLH LPRQQRTTVV HGDFRLDNLV FHPEEPEVLA 490 500 510 520 530 540 VLDWELSTLG DPLADVAYSC LAHYLPSSFP VLRGINDCDL TQLGIPAAEE YFRMYCLQMG 550 560 570 580 590 600 LPPTENWNFY MAFSFFRVAA ILQGVYKRSL TGQASSTYAE QTGKLTEFVS NLAWDFAVKE 610 620 630 640 650 660 GFRVFKEMPF TNPLTRSYHT WARPQSQWCP TGSRSYSSVP EASPAHTSRG GLVISPESLS 670 680 690 700 710 720 PPVRELYHRL KHFMEQRVYP AEPELQSHQA SAARWSPSPL IEDLKEKAKA EGLWNLFLPL 730 740 750 760 770 780 EADPEKKYGA GLTNVEYAHL CELMGTSLYA PEVCNCSAPD TGNMELLVRY GTEAQKARWL 790 800 810 820 830 840 IPLLEGKARS CFAMTEPQVA SSDATNIEAS IREEDSFYVI NGHKWWITGI LDPRCQLCVF 850 860 870 880 890 900 MGKTDPHAPR HRQQSVLLVP MDTPGIKIIR PLTVYGLEDA PGGHGEVRFE HVRVPKENMV 910 920 930 940 950 960 LGPGRGFEIA QGRLGPGRIH HCMRLIGFSE RALALMKARV KSRLAFGKPL VEQGTVLADI 970 980 990 1000 1010 1020 AQSRVEIEQA RLLVLRAAHL MDLAGNKAAA LDIAMIKMVA PSMASRVIDR AIQAFGAAGL 1030 1040 1050 SSDYPLAQFF TWARALRFAD GPDEVHRATV AKLELKHRI
	Isoform 2 [UniParc]. Checksum: A244BA80925C1BB4	FASTA	890	100,352
	10 20 30 40 50 60 MCVRSCFQSP RLQWVWRTAF LKHTQRRHQG SHRWTHLGGS TYRAVIFDMG GVLIPSPGRV 70 80 90 100 110 120 AAEWEVQNRI PSGTILKALM EGGENGPWMR FMRAEITAEG FLREFGRLCS EMLKTSVPVD 130 140 150 160 170 180 SFFSLLTSER VAKQFPVMTE AITQIRAKGL QTAVLSNNFY LPNQKSFLPL DRKQFDVIVE 190 200 210 220 230 240 SCMEGICKPD PRIYKLCLEQ LGLQPSESIF LDDLGTNLKE AARLGIHTIK VNDPETAVKE 250 260 270 280 290 300 LEALLGFTLR VGVPNTRPVK KTMEIPKDSL QKYLKDLLGI QTTGPLELLQ FDHGQSNPTY 310 320 330 340 350 360 YIRLANRDLV LRKKPPGTLL PSAHAIEREF RIMKALANAG VPVPNVLDLC EDSSVIGTPF 370 380 390 400 410 420 YVMEYCPGLI YKDPSLPGLE PSHRRAIYTA MNTVLCKIHS VDLQAVGLED YGKQGDYIPR 430 440 450 460 470 480 QVRTWVKQYR ASETSTIPAM ERLIEWLPLH LPRQQRTTVV HGDFRLDNLV FHPEEPEVLA 490 500 510 520 530 540 VLDWELSTLG DPLADVAYSC LAHYLPSSFP VLRGINDCDL TQLGIPAAEE YFRMYCLQMG 550 560 570 580 590 600 LPPTENWNFY MAFSFFRVAA ILQGVYKRSL TGQASSTYAE QTGKLTEFVS NLAWDFAVKE 610 620 630 640 650 660 GFRVFKEMPF TNPLTRSYHT WARPQSQWCP TGSRSYSSVP EASPAHTSRG GLVISPESLS 670 680 690 700 710 720 PPVRELYHRL KHFMEQRVYP AEPELQSHQA SAARWSPSPL IEDLKEKAKA EGLWNLFLPL 730 740 750 760 770 780 EADPEKKYGA GLTNVEYAHL CELMGTSLYA PEVCNCSAPD TGNMELLVRY GTEAQKARWL 790 800 810 820 830 840 IPLLEGKARS CFAMTEPQVA SSDATNIEAS IREEDSFYVI NGHKWWITGI LDPRCQLCVF 850 860 870 880 890 MGKTDPHAPR HRQQSVLLVP MDTPGIKIIR PLTVYGLEDA PGCFLPSFSL
	Isoform 3 [UniParc]. Checksum: 7D43DC0750659E9F	FASTA	492	55,693
	10 20 30 40 50 60 MLEYLSLTFL ISVKIQGDYI PRQVRTWVKQ YRASETSTIP AMERLIEWLP LHLPRQQRTT 70 80 90 100 110 120 VVHGDFRLDN LVFHPEEPEV LAVLDWELST LGDPLADVAY SCLAHYLPSS FPVLRGINDC 130 140 150 160 170 180 DLTQLGIPAA EEYFRMYCLQ MGLPPTENWN FYMAFSFFRV AAILQGVYKR SLTGQASSTY 190 200 210 220 230 240 AEQTGKLTEF VSNLAWDFAV KEGFRVFKEM PFTNPLTRSY HTWARPQSQW CPTGSRSYSS 250 260 270 280 290 300 VPEASPAHTS RGGLVISPES LSPPVRELYH RLKHFMEQRV YPAEPELQSH QASAARWSPS 310 320 330 340 350 360 PLIEDLKEKA KAEGLWNLFL PLEADPEKKY GAGLTNVEYA HLCELMGTSL YAPEVCNCSA 370 380 390 400 410 420 PDTGNMELLV RYGTEAQKAR WLIPLLEGKA RSCFAMTEPQ VASSDATNIE ASIREEDSFY 430 440 450 460 470 480 VINGHKWWIT GILDPRCQLC VFMGKTDPHA PRHRQQSVLL VPMDTPGIKI IRPLTVYGLE 490 DAPGCFLPSF SL
	Isoform 4 [UniParc]. Checksum: 8852125314974C50	FASTA	285	32,196
	10 20 30 40 50 60 MCVRSCFQSP RLQWVWRTAF LKHTQRRHQG SHRWTHLGGS TYRAVIFDMG GVLIPSPGRV 70 80 90 100 110 120 AAEWEVQNRI PSGTILKALM EGGENGPWMR FMRAEITAEG FLREFGRLCS EMLKTSVPVD 130 140 150 160 170 180 SFFSLLTSER VAKQFPVMTE AITQIRAKGL QTAVLSNNFY LPNQKSFLPL DRKQFDVIVE 190 200 210 220 230 240 SCMEGICKPD PRIYKLCLEQ LGLQPSESIF LDDLGTNLKE AARLGIHTIK VNDPETAVKE 250 260 270 280 LEALLGFTLR VGVPNTRPVK KTMEIPKDSL QKYLKDLLGI QTTGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1." Ye X., Ji C., Zhou C., Zeng L., Gu S., Ying K., Xie Y., Mao Y. Mol. Biol. Rep. 31:191-195(2004) [PubMed: 15560374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Skin.
[4]	"Identification and characterization of new long chain acyl-CoA dehydrogenases." He M., Pei Z., Mohsen A.W., Watkins P., Murdoch G., Van Veldhoven P.P., Ensenauer R., Vockley J. Mol. Genet. Metab. 102:418-429(2011) [PubMed: 21237683] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY323912 mRNA. Translation: AAQ88260.1. AK092356 mRNA. Translation: BAC03869.1. AK097425 mRNA. Translation: BAC05046.1. BC015056 mRNA. Translation: AAH15056.1. Different initiation. BC126358 mRNA. Translation: AAI26359.1.
IPI	IPI00418639. IPI00797832. IPI00843833. IPI00843880.
RefSeq	NP_001130010.1. NM_001136538.1. NP_079523.3. NM_025247.5.
UniGene	Hs.331141.
3D structure databases
HSSP	HSSP built from PDB template 1Z4O based on UniProtKB P71447.
ProteinModelPortal	Q6JQN1.
SMR	Q6JQN1. Positions 41-261, 264-600, 660-1058.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6JQN1. 1 interaction.
STRING	Q6JQN1.
Polymorphism databases
DMDM	74748862.
Proteomic databases
PRIDE	Q6JQN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313698; ENSP00000325137; ENSG00000111271.
GeneID	80724.
KEGG	hsa:80724.
UCSC	uc001tso.2. human. uc001tsp.1. human. uc001tsq.1. human.
Organism-specific databases
CTD	80724.
GeneCards	GC12P112123.
H-InvDB	HIX0011001.
HGNC	HGNC:21597. ACAD10.
MIM	611181. gene.
neXtProt	NX_Q6JQN1.
PharmGKB	PA134976754.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13507.
GeneTree	ENSGT00590000082906.
HOVERGEN	HBG057142.
InParanoid	Q6JQN1.
PhylomeDB	Q6JQN1.
Gene expression databases
ArrayExpress	Q6JQN1.
Bgee	Q6JQN1.
CleanEx	HS_ACAD10.
Genevestigator	Q6JQN1.
Family and domain databases
InterPro	IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR009075. AcylCo_DH/oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR009100. AcylCoA_DH/oxidase. IPR002575. Aminoglycoside_PTrfase. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR006402. HAD-SF_hydro_IA_v3. IPR011945. HAD-SF_ppase_IA/epoxid_hydro_N. IPR005833. Haloacid_DH/epoxide_hydro. IPR011009. Kinase-like_dom. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 1 hit.
KO	K11729.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. PF01636. APH. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00413. HADHALOGNASE.
SUPFAM	SSF56645. AcylCoA_dehyd_NM. 1 hit. SSF47203. AcylCoADH_C_like. 1 hit. SSF56784. HAD-like_dom. 1 hit. SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR02247. HAD-1A3-hyp. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit.
PROSITE	PS00072. ACYL_COA_DH_1. False negative. PS00073. ACYL_COA_DH_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	71031.
SOURCE	Search...

Entry information

Entry name

ACD10_HUMAN

Accession

Primary (citable) accession number: Q6JQN1
Secondary accession number(s): Q8N828, Q8NAP2, Q96BX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.