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Protein
Submitted name:

Prion protein

Gene
N/A
Organism
Pavo muticus (Green peafowl)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrionImported
LigandCopperSAAS annotation, Metal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Prion proteinImported
OrganismiPavo muticus (Green peafowl)Imported
Taxonomic identifieri9050 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaePavo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500427518525 – 266Sequence analysisAdd BLAST242

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Monomer and homodimer. Has a tendency to aggregate into amyloid fibrils containing a cross-beta spine, formed by a steric zipper of superposed beta-strands. Soluble oligomers may represent an intermediate stage on the path to fibril formation. Copper binding may promote oligomerization.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ6JM14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 135Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST16
Domaini217 – 235Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST19

Sequence similaritiesi

Belongs to the prion family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG008260.

Family and domain databases

Gene3Di1.10.790.10. 1 hit.
InterProiView protein in InterPro
IPR000817. Prion.
IPR022416. Prion/Doppel_prot_b-ribbon_dom.
IPR025860. Prion_N_dom.
PANTHERiPTHR10502:SF163. PTHR10502:SF163. 1 hit.
PfamiView protein in Pfam
PF00377. Prion. 1 hit.
PF11587. Prion_bPrPp. 1 hit.
SMARTiView protein in SMART
SM00157. PRP. 1 hit.
SUPFAMiSSF54098. SSF54098. 1 hit.
PROSITEiView protein in PROSITE
PS00291. PRION_1. 1 hit.
PS00706. PRION_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6JM14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLLTTCCL LALLLAACTD VALSKKGKGK PGGGGWGGGS HRQPSYPRQP
60 70 80 90 100
GYPHNPGYPH NPGYPHNPGY PHNPGYPQNP GYPHNPGYPG WGQGYNPSSG
110 120 130 140 150
GSYHNQKPWK PPKTNFKHVA GAAAAGAVVG GLGGYALGRA MSGMSYHFDS
160 170 180 190 200
PDEYRWWNEN SARYPNRVYY RDYSSPVSQD VFVADCFNIT VTEYSIGPAA
210 220 230 240 250
KKNTSEAAPA ANQTDVEMEN KVVTKVIREM CVQQYREYRL ASGIQLHPAD
260
TWLAVLLLLA TLFAMH
Length:266
Mass (Da):28,984
Last modified:July 5, 2004 - v1
Checksum:i3CCE8F4797D04EDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365065 Genomic DNA. Translation: AAR21236.1.

Similar proteinsi

Entry informationi

Entry nameiQ6JM14_PAVMU
AccessioniPrimary (citable) accession number: Q6JM14
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)