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Q6JIZ0

- Q6JIZ0_MOUSE

UniProt

Q6JIZ0 - Q6JIZ0_MOUSE

Protein
Submitted name:

Acetyl-CoA carboxylase 2

Gene

Acacb

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Cofactori

    Biotin.SAAS annotation

    GO - Molecular functioni

    1. acetyl-CoA carboxylase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. biotin carboxylase activity Source: InterPro
    4. metal ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: MGI

    Keywords - Molecular functioni

    LigaseSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, BiotinSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi6.4.1.2. 244.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Acetyl-CoA carboxylase 2Imported
    Gene namesi
    Name:AcacbImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:2140940. Acacb.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6JIZ0.

    PTM databases

    PhosphoSiteiQ6JIZ0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6JIZ0.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1859452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6JIZ0.
    SMRiQ6JIZ0. Positions 229-749, 875-967, 1683-2409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains ATP-grasp domain.SAAS annotation
    Contains biotin carboxylation domain.SAAS annotation
    Contains biotinyl-binding domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000214115.
    HOVERGENiHBG005371.
    InParanoidiQ6JIZ0.
    KOiK11262.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProiIPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR011762. COA_CT_N.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view]
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS50980. COA_CT_NTER. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6JIZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLLLFLTCL VFSCLTFSWL KIWGKMTDSK PLTNSKVEAN LLSSEESLSA     50
    SELSGEQLQE HGDHSCLSYR GPRDASQQRN SLPSSCQRPP RNPLSSNDTW 100
    PSPELQTNWT AAPGPEVPDA NGLPFPARPP SQRTVSPSRE DRKQAHIKRQ 150
    LMTSFILGSL DDNSSDEDPS AGSFQNSSRK SSRASLGTLS QEAALNTSDP 200
    ESHAPTMRPS MSGLHLVKRG REHKKLDLHR DFTVASPAEF VTRFGGNRVI 250
    EKVLIANNGI AAVKCMRSIR RWAYEMFRNE RAIRFVVMVT PEDLKANAEY 300
    IKMADQYVPV PGGPNNNNYA NVELIIDIAK RIPVQAVWAG WGHASENPKL 350
    PELLCKHEIA FLGPPSEAMW ALGDKIASTI VAQTLQIPTL PWSGSGLTVE 400
    WTEDSRHQGK CISVPEDVYE QGCVKDVDEG LQAAEKIGFP LMIKASEGGG 450
    GKGIRKAESA EDFPMLFRQV QSEIPGSPIF LMKLAQNARH LEVQVLADQY 500
    GNAVSLFGRD CSIQRRHQKI IEEAPATIAA PAVSEFMEQC AVLLAKMVGY 550
    VSAGTVEYLY SRDGSFHFLE LNPRLQVEHP CTEMIADVNL PAAQLQIAMG 600
    VPLHRLKDIR LLYGESPWGV TPIPFETPLS PPIARGHVIA ARITSENPDE 650
    GFKPSSGTVQ ELNFRSNKNV WGYFSVAAAG GLHEFADSQF GHCFSWGENR 700
    EEAISNMVVA LKELSIRGDF RTTVEYLVNL LETESFQNND IDTGWLDHLI 750
    AQRVQAEKPD IMLGVVCGAL NVADAMFRTC MTEFLHSLER GQVLPADSLL 800
    NIVDVELIYG GIKYALKVAR QSLTMFVLIM NGCHIEIDAH RLNDGGLLLS 850
    YNGSSYTTYM KEEVDSYRIT IGNKTCVFEK ENDPTVLRSP SAGKLMQYTV 900
    EDGDHVEAGS SYAEMEVMKM IMTLNVQESG RVKYIKRPGV ILEAGCVVAR 950
    LELDDPSKVH AAQPFTGELP AQQTLPILGE KLHQVFHGVL ENLTNVMSGY 1000
    CLPEPFFSMK LKDWVQKLMM TLRHPSLPLL ELQEIMTSVA GRIPAPVEKA 1050
    VRRVMAQYAS NITSVLCQFP SQQIATILDC HAATLQRKAD REVFFMNTQS 1100
    IVQLVQRYRS GTRGYMKAVV LDLLRKYLNV EHHFQQAHYD KCVINLREQF 1150
    KPDMTQVLDC IFSHSQVAKK NQLVTMLIDE LCGPDPTLSD ELTSILCELT 1200
    QLSRSEHCKV ALRARQVLIA SHLPSYELRH NQVESIFLSA IDMYGHQFCP 1250
    ENLKKLILSE TTIFDVLPTF FYHENKVVCM ASLEVYVRRG YIAYELNSLQ 1300
    HRELPDGTCV VEFQSMLPSS HPNRMAVPIS VSNPDLLRHS TELFMDSGFS 1350
    PLCQRMGAMV AFRRFEEFTR NFDEVISCFA NVQTDTLLFS KACTSLYSEE 1400
    DNKSLREEPI HILNVAIQCA DHMEDEALVP VFRAFVQSKK HILVDYGLRR 1450
    ITFLVAQERE FPKFFTFRAR DEFAEDRIYR HLEPALAFQL ELSRMRNFDL 1500
    TAVPCANHKM HLYLGAAKVK EGLEVTDHRF FIRAIIRHSD LITKEASFEY 1550
    LQNEGERLLL EAMDELEVAF NNTSVRTDCN HIFLNFVPTV IMDPLKIEES 1600
    VRDMVMRYGS RLWKLRVLQA EVKINIRQTT SDSAIPIRLF ITNESGYYLD 1650
    ISLYREVTDS RSGNIMFHSF GNKQGSLHGM LINTPYVTKD LLQAKRFQAQ 1700
    SLGTTYVYDF PEMFRQALFK LWGSPEKYPK DILTYTELVL DSQGQLVEMN 1750
    RLPGCNEVGM VAFKMRFKTP EYPEGRDAVV IGNDITFQIG SFGIGEDFLY 1800
    LRASEMARTE GIPQIYLAAN SGARMGLAEE IKQIFQVAWV DPEDPHKGFR 1850
    YLYLTPQDYT QISSQNSVHC KHIEDEGESR YVIVDVIGKD ANLGVENLRG 1900
    SGMIAGEASL AYEKTVTISM VTCRALGIGA YLVRLGQRVI QVENSHIILT 1950
    GAGALNKVLG REVYTSNNQL GGVQIMHTNG VSHVTVPDDF EGVCTILEWL 2000
    SFIPKDNRSP VPITTPSDPI DREIEFTPTK APYDPRWMLA GRPHPTLKGT 2050
    WQSGFFDHGS FKEIMAPWAQ TVVTGRARLG GIPVGVIAVE TRTVEVAVPA 2100
    DPANLDSEAK IIQQAGQVWF PDSAYKTAQV IRDFNKERLP LMIFANWRGF 2150
    SGGMKDMYEQ MLKFGAYIVD GLRLYEQPIL IYIPPCAELR GGSWVVLDST 2200
    INPLCIEMYA DKESRGGVLE PEGTVEIKFR KKDLVKTIRR IDPVCKKLVG 2250
    QLGKAQLPDK DRKELEGQLK AREELLLPIY HQVAVQFADL HDTPGHMLEK 2300
    GIISDVLEWK TARTFFYWRL RRLLLEAQVK QEILRASPEL SHEHTQSMLR 2350
    RWFVETEGAV KAYLWDSNQV VVQWLEQHWS AKDGLRSTIR ENINYLKRDS 2400
    VLKTIQSLVQ EHPEVIMDCV AYLSQHLTPA ERIQVAQLLS TTESPASS 2448
    Length:2,448
    Mass (Da):275,668
    Last modified:July 5, 2004 - v1
    Checksum:i0B8649F5D2CF1C8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY451394 mRNA. Translation: AAS13686.1.
    RefSeqiNP_598665.2. NM_133904.2.
    UniGeneiMm.81793.

    Genome annotation databases

    GeneIDi100705.
    KEGGimmu:100705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY451394 mRNA. Translation: AAS13686.1 .
    RefSeqi NP_598665.2. NM_133904.2.
    UniGenei Mm.81793.

    3D structure databases

    ProteinModelPortali Q6JIZ0.
    SMRi Q6JIZ0. Positions 229-749, 875-967, 1683-2409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1859452.

    PTM databases

    PhosphoSitei Q6JIZ0.

    Proteomic databases

    PRIDEi Q6JIZ0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100705.
    KEGGi mmu:100705.

    Organism-specific databases

    CTDi 32.
    MGIi MGI:2140940. Acacb.

    Phylogenomic databases

    HOGENOMi HOG000214115.
    HOVERGENi HBG005371.
    InParanoidi Q6JIZ0.
    KOi K11262.

    Enzyme and pathway databases

    BRENDAi 6.4.1.2. 244.

    Miscellaneous databases

    ChiTaRSi ACACB. mouse.
    NextBioi 354598.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6JIZ0.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.226.10. 3 hits.
    InterProi IPR013537. AcCoA_COase_cen.
    IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR000022. Carboxyl_trans.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR029045. ClpP/crotonase-like_dom.
    IPR011763. COA_CT_C.
    IPR011762. COA_CT_N.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF08326. ACC_central. 1 hit.
    PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF01039. Carboxyl_trans. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view ]
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52096. SSF52096. 2 hits.
    SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS50989. COA_CT_CTER. 1 hit.
    PS50980. COA_CT_NTER. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative splicing in the mouse acetyl-CoA carboxylase 2 (ACC2) gene."
      Mao J., Wakil S.J.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: HeartImported.

    Entry informationi

    Entry nameiQ6JIZ0_MOUSE
    AccessioniPrimary (citable) accession number: Q6JIZ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)