Reviewed, UniProtKB/Swiss-Prot B0YJ81 (PTPLA_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein-tyrosine phosphatase-like member A
Alternative name(s):
    Cementum attachment protein

Gene names

Name:

PTPLA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probable anti-phosphatase. May have an important role in the development, differentiation, and maintenance of a number of different tissue types. May play a role in myogenesis and cardiogenesis By similarity.
Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Tissue specificity	Highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder.
Developmental stage	Expressed in fetal heart.
Sequence similarities	Belongs to the PTPLA family.
Caution	Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Molecular function	Developmental protein
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: B0YJ81-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: B0YJ81-2)

The sequence of this isoform differs from the canonical sequence as follows:
     126-140: IVHCLIGIVPTSVIV → VSFPSCCFSIAVIFM
     141-288: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Protein-tyrosine phosphatase-like member A		PRO_0000349315
Regions
	Transmembrane	75 – 95	21	Potential
	Transmembrane	120 – 140	21	Potential
	Transmembrane	205 – 225	21	Potential
	Transmembrane	251 – 271	21	Potential
Amino acid modifications
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	126 – 140	15	IVHCL…TSVIV → VSFPSCCFSIAVIFM in isoform 2.		VSP_035363
	Alternative sequence	141 – 288	148	Missing in isoform 2.		VSP_035364
	Natural variant	64	1	E → K: dbSNP rs7895850.		VAR_046366
	Natural variant	64	1	E → Q		VAR_046367
	Natural variant	70	1	V → F: dbSNP rs11254692.		VAR_046368
	Natural variant	227	1	H → Y: dbSNP rs1053926.		VAR_046369
Experimental info
	Sequence conflict	80	1	D → N in AAF21976. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 1CB64F23C3907F6E	FASTA	288	32,388
	10 20 30 40 50 60 MGRLTEAAAA GSGSRAAGWA GSPPTLLPLS PTSPRCAATM ASSDEDGTNG GASEAGEDRE 70 80 90 100 110 120 APGERRRLGV LATAWLTFYD IAMTAGWLVL AIAMVRFYME KGTHRGLYKS IQKTLKFFQT 130 140 150 160 170 180 FALLEIVHCL IGIVPTSVIV TGVQVSSRIF MVWLITHSIK PIQNEESVVL FLVAWTVTEI 190 200 210 220 230 240 TRYSFYTFSL LDHLPYFIKW ARYNFFIILY PVGVAGELLT IYAALPHVKK TGMFSIRLPN 250 260 270 280 KYNVSFDYYY FLLITMASYI PLFPQLYFHM LRQRRKVLHG EVIVEKDD
	Isoform 2 [UniParc]. Checksum: 21870B3D77BD5ECE		140	14,920
	10 20 30 40 50 60 MGRLTEAAAA GSGSRAAGWA GSPPTLLPLS PTSPRCAATM ASSDEDGTNG GASEAGEDRE 70 80 90 100 110 120 APGERRRLGV LATAWLTFYD IAMTAGWLVL AIAMVRFYME KGTHRGLYKS IQKTLKFFQT 130 140 FALLEVSFPS CCFSIAVIFM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human protein tyrosine phosphatase-like gene: expression profile, genomic structure, and mutation analysis in families with ARVD." Li D., Gonzalez O., Bachinski L.L., Roberts R. Gene 256:237-243(2000) [PubMed: 11054553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-64; GLN-64; PHE-70 AND TYR-227, TISSUE SPECIFICITY.
[2]	"Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene." Uwanogho D.A., Hardcastle Z., Balogh P., Mirza G., Thornburg K.L., Ragoussis J., Sharpe P.T. Genomics 62:406-416(1999) [PubMed: 10644438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS LYS-64 AND TYR-227.
[3]	"Cementum attachment protein." Arzate H., Bostrom A.G., Rose T.M., Narayanan A.S. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[4]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LYS-64 AND PHE-70. Tissue: Skeletal muscle.
[6]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-288 (ISOFORM 1).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF266852 , AF266848, AF266849, AF266850, AF266851 Genomic DNA. Translation: AAG10713.1. Different initiation. AF114494 mRNA. Translation: AAF21976.1. AY455942 mRNA. Translation: AAR22554.1. BC010353 mRNA. Translation: AAH10353.1. EF445016 Genomic DNA. Translation: ACA06060.1. EF445016 Genomic DNA. Translation: ACA06061.1. EF445016 Genomic DNA. Translation: ACA06059.1. Different initiation. CR608689 mRNA. No translation available.
RefSeq	NP_055056.3.
UniGene	Hs.114062
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	B0YJ81.
Genome annotation databases
Ensembl	ENSG00000165996. Homo sapiens. [Contig view]
GeneID	9200.
KEGG	hsa:9200.
Organism-specific databases
HGNC	HGNC:9639. PTPLA.
PharmGKB	PA33982.
GenAtlas	Search...
GeneCards	Search...
Family and domain databases
InterPro	IPR001844. Chaprnin_Cpn60. IPR007482. Tyr_Pase-like_PTPLA. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR11035. PTPLA. 1 hit.
Pfam	PF04387. PTPLA. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	34485.

Entry information

Entry name

PTPLA_HUMAN

Accession

Primary (citable) accession number: B0YJ81
Secondary accession number(s): B0YJ80 , Q6JIC5, Q96FW7, Q9HB93, Q9UHX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	April 8, 2008
Last modified:	November 25, 2008
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)