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Q6JHU7

- P3H2_CHICK

UniProt

Q6JHU7 - P3H2_CHICK

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Protein
Prolyl 3-hydroxylase 2
Gene
LEPREL1, P3H2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types II, IV and V By similarity.

Catalytic activityi

L-proline-[procollagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-proline-[procollagen] + succinate + CO2.

Cofactori

Iron By similarity.
Ascorbate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi566 – 5661Iron
Metal bindingi568 – 5681Iron
Metal bindingi638 – 6381Iron
Active sitei648 – 6481 By similarity

GO - Molecular functioni

  1. L-ascorbic acid binding Source: UniProtKB-KW
  2. iron ion binding Source: InterPro
  3. procollagen-proline 3-dioxygenase activity Source: UniProtKB

GO - Biological processi

  1. collagen metabolic process Source: UniProtKB
  2. negative regulation of cell proliferation Source: UniProtKB
  3. peptidyl-proline hydroxylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding, Vitamin C

Names & Taxonomyi

Protein namesi
Recommended name:
Prolyl 3-hydroxylase 2 (EC:1.14.11.7)
Alternative name(s):
Leprecan-like protein 1
Gene namesi
Name:LEPREL1
Synonyms:P3H2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. basement membrane Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 694671Prolyl 3-hydroxylase 2
PRO_0000240359Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi535 – 5351N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6JHU7.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011808.

Structurei

3D structure databases

ProteinModelPortaliQ6JHU7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati35 – 6834TPR 1
Add
BLAST
Repeati136 – 16934TPR 2
Add
BLAST
Repeati196 – 22934TPR 3
Add
BLAST
Repeati292 – 32534TPR 4
Add
BLAST
Domaini543 – 657115Fe2OG dioxygenase
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili386 – 41833 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi691 – 6944Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the leprecan family.
Contains 4 TPR repeats.

Keywords - Domaini

Coiled coil, Repeat, Signal, TPR repeat

Phylogenomic databases

eggNOGiNOG269251.
HOGENOMiHOG000231087.
HOVERGENiHBG053224.
InParanoidiQ6JHU7.
PhylomeDBiQ6JHU7.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
IPR011990. TPR-like_helical.
[Graphical view]
PfamiPF13640. 2OG-FeII_Oxy_3. 1 hit.
[Graphical view]
SMARTiSM00702. P4Hc. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS51471. FE2OG_OXY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6JHU7-1 [UniParc]FASTAAdd to Basket

« Hide

MAPGSRSWGA VLLLAAMLPA ACGSCGADGG PLEPFDALYA SGVEAYYGGD    50
FAGAARCLEQ ALRSRRELRA ERLRCRRRCR GQVRLAALGA GPAGELPFFG 100
ALLRRAGCLR SCEEPRLGAA SRHRAAEEVR SDFQRRVPYS YLQRAYIQLN 150
KLEEAANAAH TFFMANPEHM EIQQDIENYK TTAGKVSLID LEAKPHMEDY 200
SAGVRHYDKE EYGLAITFLE RALEGYYAED EDCQIMCEGP QRFEEHEYLE 250
YKAGLYEAIA DHYMQVLACK HDCIRELATR SGRISPIENF LPLHYDYLQF 300
AYYRVGDYVK ALECARSYLL FHPDDEDVLE NAAYYEGLLE GTVDPATIKP 350
RKEAKALLRR HKLESHLLRV AAVGLGFTYT EPNYWKRYGA RQDEHSVPSS 400
ISSEPEDGPR LSLTKKPTPK PDRELKEGGP LLYSDVKFVY NSQQLNGTQR 450
VLLDNVISEE QCRELHRVAS GIMLAGDGYR GKTSPHTPNE RFEGATVLKA 500
LKYGYEGRVP LKSARLFYDI SEKARRIVES YFMLNSTLYF SYTHLVCRTA 550
LSGQQERRND LSHPIHADNC LLDPEANECW KEPPAYTFRD YSALLYMNAD 600
FEGGEFIFTE MDAKTVTASI KPKCGRMVSF SSGGENPHGV KAVTKGQRCA 650
VALWFTLDPL YRELERIQAD EVIAMLDQEH VGRSEMNINP KDEL 694
Length:694
Mass (Da):78,430
Last modified:July 5, 2004 - v1
Checksum:i6263153C4577AFBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY463529 mRNA. Translation: AAS45238.1.
RefSeqiNP_001001530.1. NM_001001530.1.
UniGeneiGga.16244.

Genome annotation databases

GeneIDi414143.
KEGGigga:414143.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY463529 mRNA. Translation: AAS45238.1 .
RefSeqi NP_001001530.1. NM_001001530.1.
UniGenei Gga.16244.

3D structure databases

ProteinModelPortali Q6JHU7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000011808.

Proteomic databases

PaxDbi Q6JHU7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414143.
KEGGi gga:414143.

Organism-specific databases

CTDi 55214.

Phylogenomic databases

eggNOGi NOG269251.
HOGENOMi HOG000231087.
HOVERGENi HBG053224.
InParanoidi Q6JHU7.
PhylomeDBi Q6JHU7.

Miscellaneous databases

NextBioi 20818680.
PROi Q6JHU7.

Family and domain databases

Gene3Di 1.25.40.10. 3 hits.
InterProi IPR005123. Oxoglu/Fe-dep_dioxygenase.
IPR006620. Pro_4_hyd_alph.
IPR011990. TPR-like_helical.
[Graphical view ]
Pfami PF13640. 2OG-FeII_Oxy_3. 1 hit.
[Graphical view ]
SMARTi SM00702. P4Hc. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
PS51471. FE2OG_OXY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes."
    Vranka J.A., Sakai L.Y., Bachinger H.P.
    J. Biol. Chem. 279:23615-23621(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiP3H2_CHICK
AccessioniPrimary (citable) accession number: Q6JHU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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