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Q6JEL2 (KLH10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch-like protein 10
Gene names
Name:KLHL10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 6 Kelch repeats.

Sequence caution

The sequence BAB71387.1 differs from that shown. Reason: Erroneous termination at position 609. Translated as stop.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 608608Kelch-like protein 10
PRO_0000119112

Regions

Domain39 – 10668BTB
Repeat292 – 33948Kelch 1
Repeat340 – 38647Kelch 2
Repeat388 – 43346Kelch 3
Repeat434 – 48047Kelch 4
Repeat481 – 52747Kelch 5
Repeat529 – 57446Kelch 6

Experimental info

Sequence conflict5591D → G in BAB71387. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6JEL2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 669A5C3D46472915

FASTA60868,942
        10         20         30         40         50         60 
MEMESAAAST RFHQPHMERK MSAMACEIFN ELRLEGKLCD VVIKVNGFEF SAHKNILCSC 

        70         80         90        100        110        120 
SSYFRALFTS GWNNTEKKVY NIPGISPDMM KLIIEYAYTR TVPITPDNVE KLLAAADQFN 

       130        140        150        160        170        180 
IMGIVRGCCE FLKSELCLDN CIGICKFTDY YYCPELRQKA YMFILHNFEE MVKVSAEFLE 

       190        200        210        220        230        240 
LSVTELKDII EKDELNVKQE DAVFEAILKW ISHDPQNRKQ HISILLPKVR LALMHAEYFM 

       250        260        270        280        290        300 
NNVKMNDYVK DSEECKPVII NALKAMYDLN MNGPSNSDFT NPLTRPRLPY AILFAIGGWS 

       310        320        330        340        350        360 
GGSPTNAIEA YDARADRWVN VTCEEESPRA YHGAAYLKGY VYIIGGFDSV DYFNSVKRFD 

       370        380        390        400        410        420 
PVKKTWHQVA PMHSRRCYVS VTVLGNFIYA MGGFDGYVRL NTAERYEPET NQWTLIAPMH 

       430        440        450        460        470        480 
EQRSDASATT LYGKVYICGG FNGNECLFTA EVYNTESNQW TVIAPMRSRR SGIGVIAYGE 

       490        500        510        520        530        540 
HVYAVGGFDG ANRLRSAEAY SPVANTWRTI PTMFNPRSNF GIEVVDDLLF VVGGFNGFTT 

       550        560        570        580        590        600 
TFNVECYDEK TDEWYDAHDM SIYRSALSCC VVPGLANVEE YAARRDNFPG LALRDEVKYS 


ASTSTLPV

« Hide

References

« Hide 'large scale' references
[1]"Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice."
Yan W., Ma L., Burns K.H., Matzuk M.M.
Proc. Natl. Acad. Sci. U.S.A. 101:7793-7798(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY495339 mRNA. Translation: AAS91792.1.
AK057224 mRNA. Translation: BAB71387.1. Sequence problems.
IPIIPI00065461.
RefSeqNP_689680.2. NM_152467.3.
UniGeneHs.127510.

3D structure databases

ProteinModelPortalQ6JEL2.
ModBaseSearch...

Protein-protein interaction databases

IntActQ6JEL2. 1 interaction.
STRING9606.ENSP00000293303.

PTM databases

PhosphoSiteQ6JEL2.

Polymorphism databases

DMDM52783044.

Proteomic databases

PaxDbQ6JEL2.
PRIDEQ6JEL2.

Protocols and materials databases

DNASU317719.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293303; ENSP00000293303; ENSG00000161594.
ENST00000568725; ENSP00000454897; ENSG00000261631.
GeneID317719.
KEGGhsa:317719.
UCSCuc010cxr.3. human.

Organism-specific databases

CTD317719.
GeneCardsGC17P039992.
HGNCHGNC:18829. KLHL10.
HPAHPA023853.
MIM608778. gene.
neXtProtNX_Q6JEL2.
PharmGKBPA134969977.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG280629.
HOGENOMHOG000230814.
HOVERGENHBG103704.
InParanoidQ6JEL2.
KOK10448.
OMAPRAYHGT.
OrthoDBEOG4VT5WQ.
PhylomeDBQ6JEL2.

Gene expression databases

ArrayExpressQ6JEL2.
BgeeQ6JEL2.
CleanExHS_KLHL10.
GenevestigatorQ6JEL2.
GermOnlineENSG00000161594. Homo sapiens.

Family and domain databases

Gene3D2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin.
IPR006652. Kelch_1.
[Graphical view]
PfamPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 5 hits.
[Graphical view]
PIRSFPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
PROSITEPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi317719.
NextBio96387.
SOURCESearch...

Entry information

Entry nameKLH10_HUMAN
AccessionPrimary (citable) accession number: Q6JEL2
Secondary accession number(s): Q6NW28, Q96MC0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents