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Protein

Protein NDRG1

Gene

Ndrg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHERiratno-q6je36. Ndr_family.
MEROPSiS33.988.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NDRG1
Alternative name(s):
N-myc downstream-regulated gene 1 protein
Short name:
Protein Ndr1
Gene namesi
Name:Ndrg1
Synonyms:Ndr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1307303. Ndrg1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002707582 – 394Protein NDRG1Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei319PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei328PhosphothreonineCombined sources1
Modified residuei330PhosphoserineCombined sources1
Modified residuei332Phosphoserine; by SGK1By similarity1
Modified residuei333PhosphoserineCombined sources1
Modified residuei335PhosphothreonineBy similarity1
Modified residuei336PhosphoserineCombined sources1
Modified residuei340PhosphothreonineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei346PhosphothreonineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356Phosphothreonine; by SGK1By similarity1
Modified residuei362PhosphoserineCombined sources1
Modified residuei364PhosphoserineBy similarity1
Modified residuei366PhosphothreonineCombined sources1
Modified residuei375PhosphothreonineCombined sources1

Post-translational modificationi

Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6JE36.
PRIDEiQ6JE36.

PTM databases

iPTMnetiQ6JE36.
PhosphoSitePlusiQ6JE36.

Expressioni

Gene expression databases

BgeeiENSRNOG00000007393.
GenevisibleiQ6JE36. RN.

Interactioni

Subunit structurei

Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1. Interacts with APOA1, APOA2, PRA1 and RTN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010811.

Structurei

3D structure databases

ProteinModelPortaliQ6JE36.
SMRiQ6JE36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati339 – 348110
Repeati349 – 358210
Repeati359 – 368310

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni339 – 3683 X 10 AA tandem repeats of G-[PST]-R-S-R-S-H-T-S-EAdd BLAST30

Sequence similaritiesi

Belongs to the NDRG family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2931. Eukaryota.
ENOG410XSPF. LUCA.
GeneTreeiENSGT00390000001874.
HOGENOMiHOG000230891.
HOVERGENiHBG052591.
InParanoidiQ6JE36.
KOiK18266.
OMAiNNVEVVH.
OrthoDBiEOG091G09VW.
PhylomeDBiQ6JE36.
TreeFamiTF313168.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR004142. NDRG.
IPR030693. NDRG1.
PANTHERiPTHR11034. PTHR11034. 1 hit.
PTHR11034:SF18. PTHR11034:SF18. 1 hit.
PfamiView protein in Pfam
PF03096. Ndr. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6JE36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRELHDVDL AEVKPLVEKG ESITGLLQEF DVQEQDIETL HGSLHVTLCG
60 70 80 90 100
TPKGNRPVIL TYHDIGMNHK TCYNPLFNSE DMQEITQHFA VCHVDAPGQQ
110 120 130 140 150
DGAPSFPVGY MYPSMDQLAE MLPGVLHKFG LKSVIGMGTG AGAYILTRFA
160 170 180 190 200
LNNPEMVEGL VLMNVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE
210 220 230 240 250
IHSNVEVVHT YRQHILNDMN PSNLHLFISA YNSRRDLEIE RPMPGTHTVT
260 270 280 290 300
LQCPALLVVG DNSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK
310 320 330 340 350
LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLEGT RSRSHTSEGP
360 370 380 390
RSRSHTSEGS RSRSHTSEDA RLNITPSSGA TGNNAGPKSM EVSC
Length:394
Mass (Da):42,955
Last modified:July 5, 2004 - v1
Checksum:i42B2B95FBDBC9A16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY500369 mRNA. Translation: AAS78638.1.
BC081898 mRNA. Translation: AAH81898.1.
RefSeqiNP_001011991.1. NM_001011991.1.
UniGeneiRn.153992.

Genome annotation databases

EnsembliENSRNOT00000010811; ENSRNOP00000010811; ENSRNOG00000007393.
GeneIDi299923.
KEGGirno:299923.
UCSCiRGD:1307303. rat.

Similar proteinsi

Entry informationi

Entry nameiNDRG1_RAT
AccessioniPrimary (citable) accession number: Q6JE36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families