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Q6JE36

- NDRG1_RAT

UniProt

Q6JE36 - NDRG1_RAT

Protein

Protein NDRG1

Gene

Ndrg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking notably of the Schwann cell and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy By similarity.By similarity

    GO - Biological processi

    1. cellular response to hypoxia Source: Ensembl
    2. DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    3. mast cell activation Source: Ensembl
    4. peripheral nervous system myelin maintenance Source: Ensembl
    5. positive regulation of spindle checkpoint Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NDRG1
    Alternative name(s):
    N-myc downstream-regulated gene 1 protein
    Short name:
    Protein Ndr1
    Gene namesi
    Name:Ndrg1
    Synonyms:Ndr1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi1307303. Ndrg1.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Nucleus By similarity. Cell membrane By similarity
    Note: Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane By similarity.By similarity

    GO - Cellular componenti

    1. cell-cell adherens junction Source: Ensembl
    2. centrosome Source: Ensembl
    3. cytosol Source: UniProtKB-SubCell
    4. microtubule Source: UniProtKB-KW
    5. nucleus Source: UniProtKB-SubCell
    6. perinuclear region of cytoplasm Source: Ensembl
    7. plasma membrane Source: UniProtKB-SubCell
    8. recycling endosome membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 394393Protein NDRG1PRO_0000270758Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei326 – 3261PhosphoserineBy similarity
    Modified residuei328 – 3281Phosphothreonine; by SGK1By similarity
    Modified residuei330 – 3301Phosphoserine; by SGK1By similarity
    Modified residuei332 – 3321Phosphoserine; by SGK1By similarity
    Modified residuei333 – 3331PhosphoserineBy similarity
    Modified residuei336 – 3361PhosphoserineBy similarity
    Modified residuei346 – 3461Phosphothreonine; by SGK1By similarity
    Modified residuei356 – 3561Phosphothreonine; by SGK1By similarity
    Modified residuei364 – 3641PhosphoserineBy similarity
    Modified residuei366 – 3661Phosphothreonine; by SGK1By similarity
    Modified residuei375 – 3751PhosphothreonineBy similarity

    Post-translational modificationi

    Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ6JE36.
    PRIDEiQ6JE36.

    PTM databases

    PhosphoSiteiQ6JE36.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6JE36.

    Interactioni

    Subunit structurei

    Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1. Interacts with APOA1, APOA2, PRA1 and RTN1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010811.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6JE36.
    SMRiQ6JE36. Positions 31-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati339 – 348101
    Repeati349 – 358102
    Repeati359 – 368103

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni339 – 368303 X 10 AA tandem repeats of G-[PST]-R-S-R-S-H-T-S-EAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NDRG family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG310435.
    GeneTreeiENSGT00390000001874.
    HOGENOMiHOG000230891.
    HOVERGENiHBG052591.
    InParanoidiQ6JE36.
    KOiK18266.
    OMAiTLHGSIH.
    OrthoDBiEOG7KH9JS.
    PhylomeDBiQ6JE36.
    TreeFamiTF313168.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR004142. NDRG.
    [Graphical view]
    PANTHERiPTHR11034. PTHR11034. 1 hit.
    PfamiPF03096. Ndr. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6JE36-1 [UniParc]FASTAAdd to Basket

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    MSRELHDVDL AEVKPLVEKG ESITGLLQEF DVQEQDIETL HGSLHVTLCG    50
    TPKGNRPVIL TYHDIGMNHK TCYNPLFNSE DMQEITQHFA VCHVDAPGQQ 100
    DGAPSFPVGY MYPSMDQLAE MLPGVLHKFG LKSVIGMGTG AGAYILTRFA 150
    LNNPEMVEGL VLMNVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE 200
    IHSNVEVVHT YRQHILNDMN PSNLHLFISA YNSRRDLEIE RPMPGTHTVT 250
    LQCPALLVVG DNSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK 300
    LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLEGT RSRSHTSEGP 350
    RSRSHTSEGS RSRSHTSEDA RLNITPSSGA TGNNAGPKSM EVSC 394
    Length:394
    Mass (Da):42,955
    Last modified:July 5, 2004 - v1
    Checksum:i42B2B95FBDBC9A16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY500369 mRNA. Translation: AAS78638.1.
    BC081898 mRNA. Translation: AAH81898.1.
    RefSeqiNP_001011991.1. NM_001011991.1.
    UniGeneiRn.153992.

    Genome annotation databases

    EnsembliENSRNOT00000010811; ENSRNOP00000010811; ENSRNOG00000007393.
    GeneIDi299923.
    KEGGirno:299923.
    UCSCiRGD:1307303. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY500369 mRNA. Translation: AAS78638.1 .
    BC081898 mRNA. Translation: AAH81898.1 .
    RefSeqi NP_001011991.1. NM_001011991.1.
    UniGenei Rn.153992.

    3D structure databases

    ProteinModelPortali Q6JE36.
    SMRi Q6JE36. Positions 31-311.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010811.

    PTM databases

    PhosphoSitei Q6JE36.

    Proteomic databases

    PaxDbi Q6JE36.
    PRIDEi Q6JE36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010811 ; ENSRNOP00000010811 ; ENSRNOG00000007393 .
    GeneIDi 299923.
    KEGGi rno:299923.
    UCSCi RGD:1307303. rat.

    Organism-specific databases

    CTDi 10397.
    RGDi 1307303. Ndrg1.

    Phylogenomic databases

    eggNOGi NOG310435.
    GeneTreei ENSGT00390000001874.
    HOGENOMi HOG000230891.
    HOVERGENi HBG052591.
    InParanoidi Q6JE36.
    KOi K18266.
    OMAi TLHGSIH.
    OrthoDBi EOG7KH9JS.
    PhylomeDBi Q6JE36.
    TreeFami TF313168.

    Miscellaneous databases

    NextBioi 645992.

    Gene expression databases

    Genevestigatori Q6JE36.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR004142. NDRG.
    [Graphical view ]
    PANTHERi PTHR11034. PTHR11034. 1 hit.
    Pfami PF03096. Ndr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Wang X., Jing N.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. Lubec G., Afjehi-Sadat L., Chen W.-Q.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 133-148; 213-234 AND 328-341, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Hippocampus and Spinal cord.

    Entry informationi

    Entry nameiNDRG1_RAT
    AccessioniPrimary (citable) accession number: Q6JE36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3