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Protein

CapZ-interacting protein

Gene

RCSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.1 Publication

GO - Molecular functioni

  • actin filament binding Source: BHF-UCL

GO - Biological processi

  • cellular hyperosmotic response Source: BHF-UCL
  • skeletal muscle contraction Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CapZ-interacting protein
Alternative name(s):
Protein kinase substrate CapZIP
RCSD domain-containing protein 1
Gene namesi
Name:RCSD1
Synonyms:CAPZIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28310. RCSD1.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671088.

Polymorphism and mutation databases

BioMutaiRCSD1.
DMDMi74758031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416CapZ-interacting proteinPRO_0000320262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei68 – 681Phosphoserine; by MAPK8; in vitroCombined sources1 Publication
Modified residuei82 – 821PhosphoserineCombined sources
Modified residuei83 – 831Phosphoserine; by MAPK8; in vitroCombined sources1 Publication
Modified residuei105 – 1051PhosphoserineCombined sources
Modified residuei108 – 1081Phosphoserine; by MAPK12 and MAPK13Combined sources1 Publication
Modified residuei116 – 1161PhosphoserineCombined sources
Modified residuei120 – 1201PhosphoserineCombined sources
Modified residuei123 – 1231PhosphoserineCombined sources
Modified residuei124 – 1241PhosphothreonineBy similarity
Modified residuei126 – 1261PhosphoserineBy similarity
Modified residuei127 – 1271PhosphoserineCombined sources
Modified residuei135 – 1351PhosphoserineBy similarity
Modified residuei143 – 1431PhosphoserineBy similarity
Modified residuei177 – 1771PhosphoserineCombined sources
Modified residuei179 – 1791Phosphoserine; by MAPKAPK2 and MAPKAPK3Combined sources1 Publication
Modified residuei216 – 2161Phosphoserine; by MAPK8; in vitroCombined sources1 Publication
Modified residuei244 – 2441Phosphoserine; by MAPKAPK2 or MAPKAPK3; in vitro1 Publication
Modified residuei267 – 2671PhosphoserineCombined sources
Modified residuei268 – 2681PhosphoserineCombined sources
Modified residuei284 – 2841PhosphoserineCombined sources
Modified residuei298 – 2981PhosphoserineCombined sources
Modified residuei333 – 3331PhosphoserineCombined sources
Modified residuei336 – 3361PhosphothreonineCombined sources
Modified residuei351 – 3511PhosphoserineCombined sources

Post-translational modificationi

Dephosphorylation results in its dissociation from CAPZA2.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6JBY9.
MaxQBiQ6JBY9.
PaxDbiQ6JBY9.
PeptideAtlasiQ6JBY9.
PRIDEiQ6JBY9.

PTM databases

iPTMnetiQ6JBY9.
PhosphoSiteiQ6JBY9.

Miscellaneous databases

PMAP-CutDBQ6JBY9.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000198771.
CleanExiHS_RCSD1.
ExpressionAtlasiQ6JBY9. baseline and differential.
GenevisibleiQ6JBY9. HS.

Organism-specific databases

HPAiHPA016597.

Interactioni

Subunit structurei

Interacts with CAPZA2 and CAPZB.1 Publication

GO - Molecular functioni

  • actin filament binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi124921. 3 interactions.
IntActiQ6JBY9. 1 interaction.
STRINGi9606.ENSP00000356828.

Structurei

3D structure databases

ProteinModelPortaliQ6JBY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini227 – 330104RCSDAdd
BLAST

Sequence similaritiesi

Contains 1 RCSD domain.Curated

Phylogenomic databases

eggNOGiENOG410IKAV. Eukaryota.
ENOG410YWC5. LUCA.
GeneTreeiENSGT00510000049038.
HOVERGENiHBG106582.
InParanoidiQ6JBY9.
KOiK18615.
OMAiKETPACK.
OrthoDBiEOG091G0DQJ.
PhylomeDBiQ6JBY9.
TreeFamiTF334159.

Family and domain databases

InterProiIPR029341. FAM21/CAPZIP.
IPR007850. RCSD.
[Graphical view]
PfamiPF15255. CAP-ZIP_m. 1 hit.
PF05177. RCSD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6JBY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEERPAETNA NVDNSASPSV AQLAGRFREQ AAAAKETPAS KPTRRKPPCS
60 70 80 90 100
LPLFPPKVDL GQNGEEKSPP NASHPPKFKV KSSPLIEKLQ ANLTFDPAAL
110 120 130 140 150
LPGASPKSPG LKAMVSPFHS PPSTPSSPGV RSRPSEAEEV PVSFDQPPEG
160 170 180 190 200
SHLPCYNKVR TRGSIKRRPP SRRFRRSQSD CGELGDFRAV ESSQQNGAKE
210 220 230 240 250
EDGDEVLPSK SKAPGSPLSS EGAAGEGVRT LGPAEKPPLR RSPSRTEKQE
260 270 280 290 300
EDRATEEAKN GEKARRSSEE VDGQHPAQEE VPESPQTSGP EAENRCGSPR
310 320 330 340 350
EEKPAGEEAE MEKATEVKGE RVQNEEVGPE HDSQETKKLE EGAAVKETPH
360 370 380 390 400
SPPGGVKGGD VPKQEKGKEK QQEGAVLEPG CSPQTGPAQL ETSSEVQSEP
410
AVPKPEDDTP VQDTKM
Length:416
Mass (Da):44,504
Last modified:July 5, 2004 - v1
Checksum:iE3E617250F965136
GO
Isoform 2 (identifier: Q6JBY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-310: Missing.

Show »
Length:106
Mass (Da):11,299
Checksum:iEE22246AC4CFF625
GO

Sequence cautioni

The sequence CAB70910 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481P → A in AAN52359 (Ref. 2) Curated
Sequence conflicti74 – 741H → Q in AAN52359 (Ref. 2) Curated
Sequence conflicti96 – 961D → E in AAN52359 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti384 – 3841Q → R.
Corresponds to variant rs34699420 [ dbSNP | Ensembl ].
VAR_039181

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 310310Missing in isoform 2. 1 PublicationVSP_031648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY530954 mRNA. Translation: AAS99235.1.
AF545852 mRNA. Translation: AAN52359.1.
CH471067 Genomic DNA. Translation: EAW90797.1.
AL031733, AL356532 Genomic DNA. Translation: CAI21377.1.
AL356532, AL031733 Genomic DNA. Translation: CAI21595.1.
BC072399 mRNA. Translation: AAH72399.1.
BC098426 mRNA. Translation: AAH98426.1.
BC101536 mRNA. Translation: AAI01537.1.
BC101562 mRNA. Translation: AAI01563.1.
BC013186 mRNA. Translation: AAH13186.1.
AL137762 mRNA. Translation: CAB70910.1. Different initiation.
CCDSiCCDS1263.1. [Q6JBY9-1]
RefSeqiNP_443094.3. NM_052862.3. [Q6JBY9-1]
UniGeneiHs.493867.
Hs.668429.

Genome annotation databases

EnsembliENST00000367854; ENSP00000356828; ENSG00000198771. [Q6JBY9-1]
GeneIDi92241.
KEGGihsa:92241.
UCSCiuc001gem.4. human. [Q6JBY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY530954 mRNA. Translation: AAS99235.1.
AF545852 mRNA. Translation: AAN52359.1.
CH471067 Genomic DNA. Translation: EAW90797.1.
AL031733, AL356532 Genomic DNA. Translation: CAI21377.1.
AL356532, AL031733 Genomic DNA. Translation: CAI21595.1.
BC072399 mRNA. Translation: AAH72399.1.
BC098426 mRNA. Translation: AAH98426.1.
BC101536 mRNA. Translation: AAI01537.1.
BC101562 mRNA. Translation: AAI01563.1.
BC013186 mRNA. Translation: AAH13186.1.
AL137762 mRNA. Translation: CAB70910.1. Different initiation.
CCDSiCCDS1263.1. [Q6JBY9-1]
RefSeqiNP_443094.3. NM_052862.3. [Q6JBY9-1]
UniGeneiHs.493867.
Hs.668429.

3D structure databases

ProteinModelPortaliQ6JBY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124921. 3 interactions.
IntActiQ6JBY9. 1 interaction.
STRINGi9606.ENSP00000356828.

PTM databases

iPTMnetiQ6JBY9.
PhosphoSiteiQ6JBY9.

Polymorphism and mutation databases

BioMutaiRCSD1.
DMDMi74758031.

Proteomic databases

EPDiQ6JBY9.
MaxQBiQ6JBY9.
PaxDbiQ6JBY9.
PeptideAtlasiQ6JBY9.
PRIDEiQ6JBY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367854; ENSP00000356828; ENSG00000198771. [Q6JBY9-1]
GeneIDi92241.
KEGGihsa:92241.
UCSCiuc001gem.4. human. [Q6JBY9-1]

Organism-specific databases

CTDi92241.
GeneCardsiRCSD1.
HGNCiHGNC:28310. RCSD1.
HPAiHPA016597.
MIMi610579. gene.
neXtProtiNX_Q6JBY9.
PharmGKBiPA142671088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKAV. Eukaryota.
ENOG410YWC5. LUCA.
GeneTreeiENSGT00510000049038.
HOVERGENiHBG106582.
InParanoidiQ6JBY9.
KOiK18615.
OMAiKETPACK.
OrthoDBiEOG091G0DQJ.
PhylomeDBiQ6JBY9.
TreeFamiTF334159.

Miscellaneous databases

GenomeRNAii92241.
PMAP-CutDBQ6JBY9.
PROiQ6JBY9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198771.
CleanExiHS_RCSD1.
ExpressionAtlasiQ6JBY9. baseline and differential.
GenevisibleiQ6JBY9. HS.

Family and domain databases

InterProiIPR029341. FAM21/CAPZIP.
IPR007850. RCSD.
[Graphical view]
PfamiPF15255. CAP-ZIP_m. 1 hit.
PF05177. RCSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPZIP_HUMAN
AccessioniPrimary (citable) accession number: Q6JBY9
Secondary accession number(s): B1AK48
, Q4G0E7, Q6IN93, Q8IZM2, Q96DX0, Q9NST4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.