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Protein

CapZ-interacting protein

Gene

RCSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.1 Publication

GO - Molecular functioni

  • actin filament binding Source: BHF-UCL

GO - Biological processi

  • cellular hyperosmotic response Source: BHF-UCL
  • skeletal muscle contraction Source: BHF-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
CapZ-interacting protein
Alternative name(s):
Protein kinase substrate CapZIP
RCSD domain-containing protein 1
Gene namesi
Name:RCSD1
Synonyms:CAPZIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198771.10
HGNCiHGNC:28310 RCSD1
MIMi610579 gene
neXtProtiNX_Q6JBY9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi92241
OpenTargetsiENSG00000198771
PharmGKBiPA142671088

Polymorphism and mutation databases

BioMutaiRCSD1
DMDMi74758031

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202621 – 416CapZ-interacting proteinAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Modified residuei68Phosphoserine; by MAPK8; in vitroCombined sources1 Publication1
Modified residuei82PhosphoserineCombined sources1
Modified residuei83Phosphoserine; by MAPK8; in vitroCombined sources1 Publication1
Modified residuei105PhosphoserineCombined sources1
Modified residuei108Phosphoserine; by MAPK12 and MAPK13Combined sources1 Publication1
Modified residuei116PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei124PhosphothreonineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei135PhosphoserineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei177PhosphoserineCombined sources1
Modified residuei179Phosphoserine; by MAPKAPK2 and MAPKAPK3Combined sources1 Publication1
Modified residuei216Phosphoserine; by MAPK8; in vitroCombined sources1 Publication1
Modified residuei244Phosphoserine; by MAPKAPK2 or MAPKAPK3; in vitro1 Publication1
Modified residuei267PhosphoserineCombined sources1
Modified residuei268PhosphoserineCombined sources1
Modified residuei284PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei336PhosphothreonineCombined sources1
Modified residuei351PhosphoserineCombined sources1

Post-translational modificationi

Dephosphorylation results in its dissociation from CAPZA2.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6JBY9
MaxQBiQ6JBY9
PaxDbiQ6JBY9
PeptideAtlasiQ6JBY9
PRIDEiQ6JBY9

PTM databases

iPTMnetiQ6JBY9
PhosphoSitePlusiQ6JBY9

Miscellaneous databases

PMAP-CutDBQ6JBY9

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000198771
CleanExiHS_RCSD1
ExpressionAtlasiQ6JBY9 baseline and differential
GenevisibleiQ6JBY9 HS

Organism-specific databases

HPAiHPA016597

Interactioni

Subunit structurei

Interacts with CAPZA2 and CAPZB.1 Publication

GO - Molecular functioni

  • actin filament binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi124921, 6 interactors
IntActiQ6JBY9, 1 interactor
STRINGi9606.ENSP00000356828

Structurei

3D structure databases

ProteinModelPortaliQ6JBY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 330RCSDAdd BLAST104

Phylogenomic databases

eggNOGiENOG410IKAV Eukaryota
ENOG410YWC5 LUCA
GeneTreeiENSGT00510000049038
HOVERGENiHBG106582
InParanoidiQ6JBY9
KOiK18615
OMAiPVQDTKM
OrthoDBiEOG091G0DQJ
PhylomeDBiQ6JBY9
TreeFamiTF334159

Family and domain databases

InterProiView protein in InterPro
IPR029341 FAM21/CAPZIP
IPR007850 RCSD
PfamiView protein in Pfam
PF15255 CAP-ZIP_m, 1 hit
PF05177 RCSD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6JBY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEERPAETNA NVDNSASPSV AQLAGRFREQ AAAAKETPAS KPTRRKPPCS
60 70 80 90 100
LPLFPPKVDL GQNGEEKSPP NASHPPKFKV KSSPLIEKLQ ANLTFDPAAL
110 120 130 140 150
LPGASPKSPG LKAMVSPFHS PPSTPSSPGV RSRPSEAEEV PVSFDQPPEG
160 170 180 190 200
SHLPCYNKVR TRGSIKRRPP SRRFRRSQSD CGELGDFRAV ESSQQNGAKE
210 220 230 240 250
EDGDEVLPSK SKAPGSPLSS EGAAGEGVRT LGPAEKPPLR RSPSRTEKQE
260 270 280 290 300
EDRATEEAKN GEKARRSSEE VDGQHPAQEE VPESPQTSGP EAENRCGSPR
310 320 330 340 350
EEKPAGEEAE MEKATEVKGE RVQNEEVGPE HDSQETKKLE EGAAVKETPH
360 370 380 390 400
SPPGGVKGGD VPKQEKGKEK QQEGAVLEPG CSPQTGPAQL ETSSEVQSEP
410
AVPKPEDDTP VQDTKM
Length:416
Mass (Da):44,504
Last modified:July 5, 2004 - v1
Checksum:iE3E617250F965136
GO
Isoform 2 (identifier: Q6JBY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-310: Missing.

Show »
Length:106
Mass (Da):11,299
Checksum:iEE22246AC4CFF625
GO

Sequence cautioni

The sequence CAB70910 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48P → A in AAN52359 (Ref. 2) Curated1
Sequence conflicti74H → Q in AAN52359 (Ref. 2) Curated1
Sequence conflicti96D → E in AAN52359 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039181384Q → R. Corresponds to variant dbSNP:rs34699420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0316481 – 310Missing in isoform 2. 1 PublicationAdd BLAST310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY530954 mRNA Translation: AAS99235.1
AF545852 mRNA Translation: AAN52359.1
CH471067 Genomic DNA Translation: EAW90797.1
AL031733 Genomic DNA No translation available.
AL356532 Genomic DNA No translation available.
BC072399 mRNA Translation: AAH72399.1
BC098426 mRNA Translation: AAH98426.1
BC101536 mRNA Translation: AAI01537.1
BC101562 mRNA Translation: AAI01563.1
BC013186 mRNA Translation: AAH13186.1
AL137762 mRNA Translation: CAB70910.1 Different initiation.
CCDSiCCDS1263.1 [Q6JBY9-1]
RefSeqiNP_443094.3, NM_052862.3 [Q6JBY9-1]
UniGeneiHs.493867
Hs.668429

Genome annotation databases

EnsembliENST00000367854; ENSP00000356828; ENSG00000198771 [Q6JBY9-1]
GeneIDi92241
KEGGihsa:92241
UCSCiuc001gem.4 human [Q6JBY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCPZIP_HUMAN
AccessioniPrimary (citable) accession number: Q6JBY9
Secondary accession number(s): B1AK48
, Q4G0E7, Q6IN93, Q8IZM2, Q96DX0, Q9NST4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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