Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 35

Gene

Tmem35

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate sympathetic neurite outgrowth upon chronic activation of the renin-angiotensin system.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35
Alternative name(s):
Spinal cord expression protein 4
TMEM35 gene-derived unknown factor 1
Gene namesi
Name:Tmem35
Synonyms:Tuf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1303093. Tmem35.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence analysisAdd
BLAST
Transmembranei115 – 13218HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi46 – 461S → A: Abolishes interaction with NGFR. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Transmembrane protein 35PRO_0000271610Add
BLAST

Proteomic databases

PaxDbiQ6JAM9.
PRIDEiQ6JAM9.

PTM databases

PhosphoSiteiQ6JAM9.

Expressioni

Tissue specificityi

Present in adrenal zona glomerusa but not in adrenal medulla (at protein level).1 Publication

Inductioni

By sodium depletion and angiotensin II in adrenal zona glomerusa (at protein level).

Gene expression databases

GenevisibleiQ6JAM9. RN.

Interactioni

Subunit structurei

May interact with NGFR.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002058.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 5412Interaction with NGFRAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM35 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ6JAM9.
OMAiVVWYQTS.
OrthoDBiEOG7V768Z.
PhylomeDBiQ6JAM9.
TreeFamiTF300206.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6JAM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRTITIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKALPESAE
160
EQPSLYEKAP QGKVKVS
Length:167
Mass (Da):18,473
Last modified:July 5, 2004 - v1
Checksum:i7F28E4D9E2CDC013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540309 mRNA. Translation: AAT08467.1.
RefSeqiNP_001001799.1. NM_001001799.1.
UniGeneiRn.45854.

Genome annotation databases

EnsembliENSRNOT00000002058; ENSRNOP00000002058; ENSRNOG00000001506.
GeneIDi308134.
KEGGirno:308134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540309 mRNA. Translation: AAT08467.1.
RefSeqiNP_001001799.1. NM_001001799.1.
UniGeneiRn.45854.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002058.

PTM databases

PhosphoSiteiQ6JAM9.

Proteomic databases

PaxDbiQ6JAM9.
PRIDEiQ6JAM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002058; ENSRNOP00000002058; ENSRNOG00000001506.
GeneIDi308134.
KEGGirno:308134.

Organism-specific databases

CTDi59353.
RGDi1303093. Tmem35.

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ6JAM9.
OMAiVVWYQTS.
OrthoDBiEOG7V768Z.
PhylomeDBiQ6JAM9.
TreeFamiTF300206.

Miscellaneous databases

NextBioi658392.
PROiQ6JAM9.

Gene expression databases

GenevisibleiQ6JAM9. RN.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Wang X., Jing N.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sodium depletion increases sympathetic neurite outgrowth and expression of a novel TMEM35 gene-derived protein (TUF1) in the rat adrenal zona glomerulosa."
    Tran P.V., Georgieff M.K., Engeland W.C.
    Endocrinology 151:4852-4860(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH NGFR, MUTAGENESIS OF SER-46, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTMM35_RAT
AccessioniPrimary (citable) accession number: Q6JAM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.