Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 35A

Gene

Tmem35a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate sympathetic neurite outgrowth upon chronic activation of the renin-angiotensin system.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35A
Alternative name(s):
Spinal cord expression protein 4
TMEM35 gene-derived unknown factor 1
Gene namesi
Name:Tmem35a
Synonyms:Tmem35, Tuf1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1303093. Tmem35.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei115 – 132HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46S → A: Abolishes interaction with NGFR. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716101 – 167Transmembrane protein 35AAdd BLAST167

Proteomic databases

PaxDbiQ6JAM9.
PRIDEiQ6JAM9.

PTM databases

PhosphoSitePlusiQ6JAM9.

Expressioni

Tissue specificityi

Present in adrenal zona glomerusa but not in adrenal medulla (at protein level).1 Publication

Inductioni

By sodium depletion and angiotensin II in adrenal zona glomerusa (at protein level).

Gene expression databases

BgeeiENSRNOG00000001506.
GenevisibleiQ6JAM9. RN.

Interactioni

Subunit structurei

May interact with NGFR.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002058.

Structurei

3D structure databases

ProteinModelPortaliQ6JAM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 54Interaction with NGFR1 PublicationAdd BLAST12

Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ6JAM9.
OMAiVVWYQTS.
OrthoDBiEOG091G0TZU.
PhylomeDBiQ6JAM9.
TreeFamiTF300206.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6JAM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRTITIV ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKALPESAE
160
EQPSLYEKAP QGKVKVS
Length:167
Mass (Da):18,473
Last modified:July 5, 2004 - v1
Checksum:i7F28E4D9E2CDC013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540309 mRNA. Translation: AAT08467.1.
RefSeqiNP_001001799.1. NM_001001799.1.
UniGeneiRn.45854.

Genome annotation databases

EnsembliENSRNOT00000002058; ENSRNOP00000002058; ENSRNOG00000001506.
GeneIDi308134.
KEGGirno:308134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540309 mRNA. Translation: AAT08467.1.
RefSeqiNP_001001799.1. NM_001001799.1.
UniGeneiRn.45854.

3D structure databases

ProteinModelPortaliQ6JAM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002058.

PTM databases

PhosphoSitePlusiQ6JAM9.

Proteomic databases

PaxDbiQ6JAM9.
PRIDEiQ6JAM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002058; ENSRNOP00000002058; ENSRNOG00000001506.
GeneIDi308134.
KEGGirno:308134.

Organism-specific databases

CTDi67564.
RGDi1303093. Tmem35.

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ6JAM9.
OMAiVVWYQTS.
OrthoDBiEOG091G0TZU.
PhylomeDBiQ6JAM9.
TreeFamiTF300206.

Miscellaneous databases

PROiQ6JAM9.

Gene expression databases

BgeeiENSRNOG00000001506.
GenevisibleiQ6JAM9. RN.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM35A_RAT
AccessioniPrimary (citable) accession number: Q6JAM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.