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Q6J9G1

- STYK1_MOUSE

UniProt

Q6J9G1 - STYK1_MOUSE

Protein

Tyrosine-protein kinase STYK1

Gene

Styk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways.1 Publication

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei152 – 1521ATPPROSITE-ProRule annotation
    Active sitei256 – 2561Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi125 – 1339ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase STYK1 (EC:2.7.10.2)
    Alternative name(s):
    Novel oncogene with kinase domain
    Short name:
    mNOK
    Serine/threonine/tyrosine kinase 1
    Gene namesi
    Name:Styk1
    Synonyms:Nok
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2141396. Styk1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 429429Tyrosine-protein kinase STYK1PRO_0000088164Add
    BLAST

    Proteomic databases

    PaxDbiQ6J9G1.
    PRIDEiQ6J9G1.

    PTM databases

    PhosphoSiteiQ6J9G1.

    Expressioni

    Tissue specificityi

    Highly expressed in colon and small intestine. Weakly or not expressed in spleen, skeletal muscle, liver, kidney, heart and brain. Expressed in transformed kidney cell lines (COS-1 and HEK293T).1 Publication

    Gene expression databases

    BgeeiQ6J9G1.
    CleanExiMM_STYK1.
    GenevestigatoriQ6J9G1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6J9G1.
    SMRiQ6J9G1. Positions 91-389.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini119 – 390272Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117500.
    HOGENOMiHOG000154447.
    HOVERGENiHBG054067.
    InParanoidiQ6J9G1.
    KOiK17510.
    OMAiSCWRWSE.
    OrthoDBiEOG771279.
    PhylomeDBiQ6J9G1.
    TreeFamiTF316675.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6J9G1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGEKGHLSRV LLECSLSDKL CVVREKQYEV IIVPALLVGG FLILLAIILW    50
    LFIRGQRSQR QSPGPRGTAS VPASRGRSQE AAGHGEKVLL PLKETSVEGF 100
    LRAATPRLAK LQVPREQLLE VLEQIHSGSC GTLYHATMTT KDHPKPKSVV 150
    LKALEDPVGL QEVQDFIGRI QFYQYLGKHK NLVQLEGCCT ERLPLYMMLE 200
    DVVPGDLLSF LWTCRRDVMT MDGLLYDLTE KQIYHIGKQI LLALEFLQEK 250
    HLFHGDVAAR NILIQSDLTP KLCHLGLAYE VHAHGAISSA RSSTIPLKWL 300
    APERLLLRPA SIRGDIWSFG ILLYEMVTLG APPYPEVPPT SILQYLQRKK 350
    IMKRPSSCSH AMYNIMKCCW RWSEDSRPLL GQLLQRLEAA SRSADDKAVL 400
    QVPELVVPEL YADVAGIRAE SISYSFSVL 429
    Length:429
    Mass (Da):48,121
    Last modified:April 26, 2005 - v2
    Checksum:i480130D319551F61
    GO
    Isoform 2 (identifier: Q6J9G1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-155: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:340
    Mass (Da):38,585
    Checksum:i55741BD17D1AB256
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241R → Q in AAT01225. (PubMed:15150103)Curated
    Sequence conflicti138 – 1381M → V(PubMed:15150103)Curated
    Sequence conflicti140 – 1401T → A(PubMed:15150103)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei67 – 15589Missing in isoform 2. 1 PublicationVSP_013427Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY563053 mRNA. Translation: AAT01225.1.
    AK033606 mRNA. Translation: BAC28386.1.
    AK035247 mRNA. Translation: BAC29000.1.
    CCDSiCCDS20604.1. [Q6J9G1-1]
    RefSeqiNP_766479.1. NM_172891.2. [Q6J9G1-1]
    XP_006506193.1. XM_006506130.1. [Q6J9G1-1]
    XP_006506194.1. XM_006506131.1. [Q6J9G1-1]
    XP_006506195.1. XM_006506132.1. [Q6J9G1-1]
    XP_006506196.1. XM_006506133.1. [Q6J9G1-1]
    UniGeneiMm.20114.

    Genome annotation databases

    EnsembliENSMUST00000049150; ENSMUSP00000044098; ENSMUSG00000032899. [Q6J9G1-1]
    ENSMUST00000121078; ENSMUSP00000112900; ENSMUSG00000032899. [Q6J9G1-2]
    GeneIDi243659.
    KEGGimmu:243659.
    UCSCiuc009eir.1. mouse. [Q6J9G1-1]
    uc012eub.1. mouse. [Q6J9G1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY563053 mRNA. Translation: AAT01225.1 .
    AK033606 mRNA. Translation: BAC28386.1 .
    AK035247 mRNA. Translation: BAC29000.1 .
    CCDSi CCDS20604.1. [Q6J9G1-1 ]
    RefSeqi NP_766479.1. NM_172891.2. [Q6J9G1-1 ]
    XP_006506193.1. XM_006506130.1. [Q6J9G1-1 ]
    XP_006506194.1. XM_006506131.1. [Q6J9G1-1 ]
    XP_006506195.1. XM_006506132.1. [Q6J9G1-1 ]
    XP_006506196.1. XM_006506133.1. [Q6J9G1-1 ]
    UniGenei Mm.20114.

    3D structure databases

    ProteinModelPortali Q6J9G1.
    SMRi Q6J9G1. Positions 91-389.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6J9G1.

    Proteomic databases

    PaxDbi Q6J9G1.
    PRIDEi Q6J9G1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049150 ; ENSMUSP00000044098 ; ENSMUSG00000032899 . [Q6J9G1-1 ]
    ENSMUST00000121078 ; ENSMUSP00000112900 ; ENSMUSG00000032899 . [Q6J9G1-2 ]
    GeneIDi 243659.
    KEGGi mmu:243659.
    UCSCi uc009eir.1. mouse. [Q6J9G1-1 ]
    uc012eub.1. mouse. [Q6J9G1-2 ]

    Organism-specific databases

    CTDi 55359.
    MGIi MGI:2141396. Styk1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117500.
    HOGENOMi HOG000154447.
    HOVERGENi HBG054067.
    InParanoidi Q6J9G1.
    KOi K17510.
    OMAi SCWRWSE.
    OrthoDBi EOG771279.
    PhylomeDBi Q6J9G1.
    TreeFami TF316675.

    Miscellaneous databases

    NextBioi 385889.
    PROi Q6J9G1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6J9G1.
    CleanExi MM_STYK1.
    Genevestigatori Q6J9G1.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice."
      Liu L., Yu X.-Z., Li T.-S., Song L.-X., Chen P.-L., Suo T.-L., Li Y.-H., Wang S.-D., Chen Y., Ren Y.-M., Zhang S.-P., Chang Z.-J., Fu X.-Y.
      Cancer Res. 64:3491-3499(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: KM.
      Tissue: Colon.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Cecum and Urinary bladder.

    Entry informationi

    Entry nameiSTYK1_MOUSE
    AccessioniPrimary (citable) accession number: Q6J9G1
    Secondary accession number(s): Q8BZH6, Q8BZT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3