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Q6J9G1

- STYK1_MOUSE

UniProt

Q6J9G1 - STYK1_MOUSE

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Protein

Tyrosine-protein kinase STYK1

Gene

Styk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei152 – 1521ATPPROSITE-ProRule annotation
Active sitei256 – 2561Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 1339ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase STYK1 (EC:2.7.10.2)
Alternative name(s):
Novel oncogene with kinase domain
Short name:
mNOK
Serine/threonine/tyrosine kinase 1
Gene namesi
Name:Styk1
Synonyms:Nok
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2141396. Styk1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Tyrosine-protein kinase STYK1PRO_0000088164Add
BLAST

Proteomic databases

PaxDbiQ6J9G1.
PRIDEiQ6J9G1.

PTM databases

PhosphoSiteiQ6J9G1.

Expressioni

Tissue specificityi

Highly expressed in colon and small intestine. Weakly or not expressed in spleen, skeletal muscle, liver, kidney, heart and brain. Expressed in transformed kidney cell lines (COS-1 and HEK293T).1 Publication

Gene expression databases

BgeeiQ6J9G1.
CleanExiMM_STYK1.
GenevestigatoriQ6J9G1.

Structurei

3D structure databases

ProteinModelPortaliQ6J9G1.
SMRiQ6J9G1. Positions 91-389.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 390272Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119375.
HOGENOMiHOG000154447.
HOVERGENiHBG054067.
InParanoidiQ6J9G1.
KOiK17510.
OMAiSCWRWSE.
OrthoDBiEOG771279.
PhylomeDBiQ6J9G1.
TreeFamiTF316675.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6J9G1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEKGHLSRV LLECSLSDKL CVVREKQYEV IIVPALLVGG FLILLAIILW
60 70 80 90 100
LFIRGQRSQR QSPGPRGTAS VPASRGRSQE AAGHGEKVLL PLKETSVEGF
110 120 130 140 150
LRAATPRLAK LQVPREQLLE VLEQIHSGSC GTLYHATMTT KDHPKPKSVV
160 170 180 190 200
LKALEDPVGL QEVQDFIGRI QFYQYLGKHK NLVQLEGCCT ERLPLYMMLE
210 220 230 240 250
DVVPGDLLSF LWTCRRDVMT MDGLLYDLTE KQIYHIGKQI LLALEFLQEK
260 270 280 290 300
HLFHGDVAAR NILIQSDLTP KLCHLGLAYE VHAHGAISSA RSSTIPLKWL
310 320 330 340 350
APERLLLRPA SIRGDIWSFG ILLYEMVTLG APPYPEVPPT SILQYLQRKK
360 370 380 390 400
IMKRPSSCSH AMYNIMKCCW RWSEDSRPLL GQLLQRLEAA SRSADDKAVL
410 420
QVPELVVPEL YADVAGIRAE SISYSFSVL
Length:429
Mass (Da):48,121
Last modified:April 26, 2005 - v2
Checksum:i480130D319551F61
GO
Isoform 2 (identifier: Q6J9G1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-155: Missing.

Note: No experimental confirmation available.

Show »
Length:340
Mass (Da):38,585
Checksum:i55741BD17D1AB256
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241R → Q in AAT01225. (PubMed:15150103)Curated
Sequence conflicti138 – 1381M → V(PubMed:15150103)Curated
Sequence conflicti140 – 1401T → A(PubMed:15150103)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei67 – 15589Missing in isoform 2. 1 PublicationVSP_013427Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY563053 mRNA. Translation: AAT01225.1.
AK033606 mRNA. Translation: BAC28386.1.
AK035247 mRNA. Translation: BAC29000.1.
CCDSiCCDS20604.1. [Q6J9G1-1]
RefSeqiNP_766479.1. NM_172891.2. [Q6J9G1-1]
XP_006506193.1. XM_006506130.1. [Q6J9G1-1]
XP_006506194.1. XM_006506131.1. [Q6J9G1-1]
XP_006506195.1. XM_006506132.1. [Q6J9G1-1]
XP_006506196.1. XM_006506133.1. [Q6J9G1-1]
UniGeneiMm.20114.

Genome annotation databases

EnsembliENSMUST00000049150; ENSMUSP00000044098; ENSMUSG00000032899. [Q6J9G1-1]
ENSMUST00000121078; ENSMUSP00000112900; ENSMUSG00000032899. [Q6J9G1-2]
GeneIDi243659.
KEGGimmu:243659.
UCSCiuc009eir.1. mouse. [Q6J9G1-1]
uc012eub.1. mouse. [Q6J9G1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY563053 mRNA. Translation: AAT01225.1 .
AK033606 mRNA. Translation: BAC28386.1 .
AK035247 mRNA. Translation: BAC29000.1 .
CCDSi CCDS20604.1. [Q6J9G1-1 ]
RefSeqi NP_766479.1. NM_172891.2. [Q6J9G1-1 ]
XP_006506193.1. XM_006506130.1. [Q6J9G1-1 ]
XP_006506194.1. XM_006506131.1. [Q6J9G1-1 ]
XP_006506195.1. XM_006506132.1. [Q6J9G1-1 ]
XP_006506196.1. XM_006506133.1. [Q6J9G1-1 ]
UniGenei Mm.20114.

3D structure databases

ProteinModelPortali Q6J9G1.
SMRi Q6J9G1. Positions 91-389.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q6J9G1.

Proteomic databases

PaxDbi Q6J9G1.
PRIDEi Q6J9G1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049150 ; ENSMUSP00000044098 ; ENSMUSG00000032899 . [Q6J9G1-1 ]
ENSMUST00000121078 ; ENSMUSP00000112900 ; ENSMUSG00000032899 . [Q6J9G1-2 ]
GeneIDi 243659.
KEGGi mmu:243659.
UCSCi uc009eir.1. mouse. [Q6J9G1-1 ]
uc012eub.1. mouse. [Q6J9G1-2 ]

Organism-specific databases

CTDi 55359.
MGIi MGI:2141396. Styk1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119375.
HOGENOMi HOG000154447.
HOVERGENi HBG054067.
InParanoidi Q6J9G1.
KOi K17510.
OMAi SCWRWSE.
OrthoDBi EOG771279.
PhylomeDBi Q6J9G1.
TreeFami TF316675.

Miscellaneous databases

NextBioi 385889.
PROi Q6J9G1.
SOURCEi Search...

Gene expression databases

Bgeei Q6J9G1.
CleanExi MM_STYK1.
Genevestigatori Q6J9G1.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice."
    Liu L., Yu X.-Z., Li T.-S., Song L.-X., Chen P.-L., Suo T.-L., Li Y.-H., Wang S.-D., Chen Y., Ren Y.-M., Zhang S.-P., Chang Z.-J., Fu X.-Y.
    Cancer Res. 64:3491-3499(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: KM.
    Tissue: Colon.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Cecum and Urinary bladder.

Entry informationi

Entry nameiSTYK1_MOUSE
AccessioniPrimary (citable) accession number: Q6J9G1
Secondary accession number(s): Q8BZH6, Q8BZT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3