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Q6J9G1 (STYK1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase STYK1

EC=2.7.10.2
Alternative name(s):
Novel oncogene with kinase domain
Short name=mNOK
Serine/threonine/tyrosine kinase 1
Gene names
Name:Styk1
Synonyms:Nok
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways. Ref.1

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass membrane protein Potential Ref.1.

Tissue specificity

Highly expressed in colon and small intestine. Weakly or not expressed in spleen, skeletal muscle, liver, kidney, heart and brain. Expressed in transformed kidney cell lines (COS-1 and HEK293T). Ref.1

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6J9G1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6J9G1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     67-155: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Tyrosine-protein kinase STYK1
PRO_0000088164

Regions

Transmembrane30 – 5021Helical; Potential
Domain119 – 390272Protein kinase
Nucleotide binding125 – 1339ATP By similarity

Sites

Active site2561Proton acceptor By similarity
Binding site1521ATP By similarity

Natural variations

Alternative sequence67 – 15589Missing in isoform 2.
VSP_013427

Experimental info

Sequence conflict241R → Q in AAT01225. Ref.1
Sequence conflict1381M → V Ref.1
Sequence conflict1401T → A Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 26, 2005. Version 2.
Checksum: 480130D319551F61

FASTA42948,121
        10         20         30         40         50         60 
MGEKGHLSRV LLECSLSDKL CVVREKQYEV IIVPALLVGG FLILLAIILW LFIRGQRSQR 

        70         80         90        100        110        120 
QSPGPRGTAS VPASRGRSQE AAGHGEKVLL PLKETSVEGF LRAATPRLAK LQVPREQLLE 

       130        140        150        160        170        180 
VLEQIHSGSC GTLYHATMTT KDHPKPKSVV LKALEDPVGL QEVQDFIGRI QFYQYLGKHK 

       190        200        210        220        230        240 
NLVQLEGCCT ERLPLYMMLE DVVPGDLLSF LWTCRRDVMT MDGLLYDLTE KQIYHIGKQI 

       250        260        270        280        290        300 
LLALEFLQEK HLFHGDVAAR NILIQSDLTP KLCHLGLAYE VHAHGAISSA RSSTIPLKWL 

       310        320        330        340        350        360 
APERLLLRPA SIRGDIWSFG ILLYEMVTLG APPYPEVPPT SILQYLQRKK IMKRPSSCSH 

       370        380        390        400        410        420 
AMYNIMKCCW RWSEDSRPLL GQLLQRLEAA SRSADDKAVL QVPELVVPEL YADVAGIRAE 


SISYSFSVL 

« Hide

Isoform 2 [UniParc].

Checksum: 55741BD17D1AB256
Show »

FASTA34038,585

References

« Hide 'large scale' references
[1]"A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice."
Liu L., Yu X.-Z., Li T.-S., Song L.-X., Chen P.-L., Suo T.-L., Li Y.-H., Wang S.-D., Chen Y., Ren Y.-M., Zhang S.-P., Chang Z.-J., Fu X.-Y.
Cancer Res. 64:3491-3499(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: KM.
Tissue: Colon.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Cecum and Urinary bladder.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY563053 mRNA. Translation: AAT01225.1.
AK033606 mRNA. Translation: BAC28386.1.
AK035247 mRNA. Translation: BAC29000.1.
RefSeqNP_766479.1. NM_172891.2.
XP_006506193.1. XM_006506130.1.
XP_006506194.1. XM_006506131.1.
XP_006506195.1. XM_006506132.1.
XP_006506196.1. XM_006506133.1.
UniGeneMm.20114.

3D structure databases

ProteinModelPortalQ6J9G1.
SMRQ6J9G1. Positions 91-389.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6J9G1.

Proteomic databases

PaxDbQ6J9G1.
PRIDEQ6J9G1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049150; ENSMUSP00000044098; ENSMUSG00000032899. [Q6J9G1-1]
ENSMUST00000121078; ENSMUSP00000112900; ENSMUSG00000032899. [Q6J9G1-2]
GeneID243659.
KEGGmmu:243659.
UCSCuc009eir.1. mouse. [Q6J9G1-1]
uc012eub.1. mouse. [Q6J9G1-2]

Organism-specific databases

CTD55359.
MGIMGI:2141396. Styk1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117500.
HOGENOMHOG000154447.
HOVERGENHBG054067.
InParanoidQ6J9G1.
KOK17510.
OMASCWRWSE.
OrthoDBEOG771279.
PhylomeDBQ6J9G1.
TreeFamTF316675.

Gene expression databases

BgeeQ6J9G1.
CleanExMM_STYK1.
GenevestigatorQ6J9G1.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio385889.
PROQ6J9G1.
SOURCESearch...

Entry information

Entry nameSTYK1_MOUSE
AccessionPrimary (citable) accession number: Q6J9G1
Secondary accession number(s): Q8BZH6, Q8BZT1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot