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Protein

Tyrosine-protein kinase STYK1

Gene

STYK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147ATPPROSITE-ProRule annotation1
Active sitei251Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi120 – 128ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase STYK1 (EC:2.7.10.2)
Alternative name(s):
Novel oncogene with kinase domain
Protein PK-unique
Serine/threonine/tyrosine kinase 1
Gene namesi
Name:STYK1
Synonyms:NOK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000060140.8.
HGNCiHGNC:18889. STYK1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi55359.
OpenTargetsiENSG00000060140.
PharmGKBiPA134976821.

Polymorphism and mutation databases

BioMutaiSTYK1.
DMDMi317373546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000881631 – 422Tyrosine-protein kinase STYK1Add BLAST422

Proteomic databases

PaxDbiQ6J9G0.
PeptideAtlasiQ6J9G0.
PRIDEiQ6J9G0.
TopDownProteomicsiQ6J9G0.

PTM databases

iPTMnetiQ6J9G0.
PhosphoSitePlusiQ6J9G0.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.3 Publications

Gene expression databases

BgeeiENSG00000060140.
CleanExiHS_STYK1.
ExpressionAtlasiQ6J9G0. baseline and differential.
GenevisibleiQ6J9G0. HS.

Organism-specific databases

HPAiHPA040468.
HPA048569.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GSK3BP498412EBI-6424915,EBI-373586

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120638. 1 interactor.
IntActiQ6J9G0. 2 interactors.
MINTiMINT-4724498.
STRINGi9606.ENSP00000075503.

Structurei

3D structure databases

ProteinModelPortaliQ6J9G0.
SMRiQ6J9G0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 384Protein kinasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00880000137919.
HOGENOMiHOG000154447.
HOVERGENiHBG054067.
InParanoidiQ6J9G0.
KOiK17510.
OMAiSCWRWSE.
OrthoDBiEOG091G09VY.
PhylomeDBiQ6J9G0.
TreeFamiTF316675.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6J9G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMTRMLLEC SLSDKLCVIQ EKQYEVIIVP TLLVTIFLIL LGVILWLFIR
60 70 80 90 100
EQRTQQQRSG PQGIAPVPPP RDLSWEAGHG GNVALPLKET SVENFLGATT
110 120 130 140 150
PALAKLQVPR EQLSEVLEQI CSGSCGPIFR ANMNTGDPSK PKSVILKALK
160 170 180 190 200
EPAGLHEVQD FLGRIQFHQY LGKHKNLVQL EGCCTEKLPL YMVLEDVAQG
210 220 230 240 250
DLLSFLWTCR RDVMTMDGLL YDLTEKQVYH IGKQVLLALE FLQEKHLFHG
260 270 280 290 300
DVAARNILMQ SDLTAKLCGL GLAYEVYTRG AISSTQTIPL KWLAPERLLL
310 320 330 340 350
RPASIRADVW SFGILLYEMV TLGAPPYPEV PPTSILEHLQ RRKIMKRPSS
360 370 380 390 400
CTHTMYSIMK SCWRWREADR PSPRELRLRL EAAIKTADDE AVLQVPELVV
410 420
PELYAAVAGI RVESLFYNYS ML
Length:422
Mass (Da):47,577
Last modified:January 11, 2011 - v4
Checksum:iAAD45F481BD61C73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192M → V in AAK34949 (PubMed:12841579).Curated1
Sequence conflicti192M → V in AAT01226 (PubMed:15150103).Curated1
Sequence conflicti304S → R in AAK34949 (PubMed:12841579).Curated1
Sequence conflicti304S → R in AAT01226 (PubMed:15150103).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03076671R → G. Corresponds to variant dbSNP:rs6650202Ensembl.1
Natural variantiVAR_022245204S → G6 PublicationsCorresponds to variant dbSNP:rs3759259Ensembl.1
Natural variantiVAR_041841210R → W1 PublicationCorresponds to variant dbSNP:rs34981955Ensembl.1
Natural variantiVAR_041842237L → S1 PublicationCorresponds to variant dbSNP:rs55877878Ensembl.1
Natural variantiVAR_041843379R → H1 PublicationCorresponds to variant dbSNP:rs34638573Ensembl.1
Natural variantiVAR_041844395V → I in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_041845400V → L1 PublicationCorresponds to variant dbSNP:rs55766125Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251059 mRNA. Translation: AAK34949.1.
AY563054 mRNA. Translation: AAT01226.1.
AK313906 mRNA. Translation: BAG36629.1.
AL353940 mRNA. Translation: CAB89250.1.
AC021049 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96200.1.
BC093822 mRNA. Translation: AAH93822.1.
BC093824 mRNA. Translation: AAH93824.1.
CCDSiCCDS8629.1.
PIRiT48680.
RefSeqiNP_060893.2. NM_018423.2.
XP_005253474.1. XM_005253417.2.
XP_011519038.1. XM_011520736.1.
XP_011519039.1. XM_011520737.2.
XP_011519040.1. XM_011520738.2.
UniGeneiHs.24979.

Genome annotation databases

EnsembliENST00000075503; ENSP00000075503; ENSG00000060140.
GeneIDi55359.
KEGGihsa:55359.
UCSCiuc001qys.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTYK1_HUMAN
AccessioniPrimary (citable) accession number: Q6J9G0
Secondary accession number(s): B2R9T2
, Q52LR3, Q9BXY2, Q9NSH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: January 11, 2011
Last modified: September 27, 2017
This is version 128 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families