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Protein

Calpain-11

Gene

Capn11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.By similarity

Catalytic activityi

Broad endopeptidase specificity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei115Sequence analysis1
Active sitei272Sequence analysis1
Active sitei296Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi599 – 6101PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi629 – 6402PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.22.B31. 3474.

Protein family/group databases

MEROPSiC02.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-11Imported (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 11By similarity
Short name:
CANP 11By similarity
Gene namesi
Name:Capn11Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1352490. Capn11.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562191 – 714Calpain-11Add BLAST714

Proteomic databases

PaxDbiQ6J756.
PRIDEiQ6J756.

PTM databases

iPTMnetiQ6J756.
PhosphoSitePlusiQ6J756.

Expressioni

Tissue specificityi

Expressed exclusively in testis, where it is restricted to spermatocytes and during the later stages of meiosis (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000058626.
ExpressionAtlasiQ6J756. baseline and differential.
GenevisibleiQ6J756. MM.

Interactioni

Subunit structurei

Heterodimer of a large (catalytic) and a small (regulatory) subunit.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113132.

Structurei

3D structure databases

ProteinModelPortaliQ6J756.
SMRiQ6J756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 354Calpain catalyticPROSITE-ProRule annotationAdd BLAST300
Domaini586 – 621EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini616 – 651EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni355 – 527Domain IIIBy similarityAdd BLAST173
Regioni528 – 543LinkerBy similarityAdd BLAST16
Regioni544 – 713Domain IVBy similarityAdd BLAST170

Sequence similaritiesi

Belongs to the peptidase C2 family.Sequence analysis
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ6J756.
KOiK08580.
OMAiEKHSESW.
OrthoDBiEOG091G049E.
PhylomeDBiQ6J756.
TreeFamiTF314748.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6J756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNYSDISWA EKGMVATINH SRLKDKGVGQ HQNAYNYKNQ NYEDLRAECL
60 70 80 90 100
RKGELFEDPF FPAEPRSIGV KNLGPNSEHM QNIYWQRPKD IIHNPQFITN
110 120 130 140 150
DFSPTDICQG ILGDCWLLAA IGSLTTCPKL LYRVVPRNQS FKKNYAGIFH
160 170 180 190 200
FQLWQFGHWL NVVVDDRLPT RNNKLVFVHA SHRQDFWSAL LEKAYAKLIG
210 220 230 240 250
SYGALSGGST LEGLEDFTGG VAQCIPLQKP PGNMLRLLKK ALEKSSLMGC
260 270 280 290 300
SIEVTDNSEV ETMTHNMLVR GHAYAVTGLE DVYYRDKLET LIRIQNPWGR
310 320 330 340 350
VEWNGAWSDK ATEWEEVSPD VRVQLLHKKD DGDFWMSYED FMSNFTLLEI
360 370 380 390 400
CNLTPDALNT WDYKSRWHST FYEGSWRRGS TAGGCRNHPE TFWSNPQFKI
410 420 430 440 450
SLPEVDDPED DSEKNEMVCT CLVALMQKNW RHAREGPQLL TIGFVIFSVP
460 470 480 490 500
KEFQNLRDIH LKKDFFLKYR DHGFSEIFIN SREVNSHLRL PPGEYVIIPS
510 520 530 540 550
TYEPHKDADF LLRVFTEKHS ETWLLDDANR FEHLQEETVT DKDLDKDSLQ
560 570 580 590 600
LFKIMANEDG EVDMYALHKL LNRMTAKLRN FKTKGFSLEV CRRMINLLDK
610 620 630 640 650
DGSGKLELHE FQVLWKKIKK WTEIFKECDE DRSGNLNSYE MRLAIEKAGI
660 670 680 690 700
KMNNRVTEVV VARYSDNMIV DFDSFLNCFL RLKAMFAFFL SMDTKKTGSI
710
CLDINQWLQI TMWG
Length:714
Mass (Da):82,970
Last modified:July 5, 2004 - v1
Checksum:iFB65F4C3C2D9D09D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY578330 mRNA. Translation: AAT27434.1.
CCDSiCCDS50121.1.
RefSeqiNP_001013789.1. NM_001013767.2.
UniGeneiMm.426026.

Genome annotation databases

EnsembliENSMUST00000120717; ENSMUSP00000113132; ENSMUSG00000058626.
GeneIDi268958.
KEGGimmu:268958.
UCSCiuc008crh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY578330 mRNA. Translation: AAT27434.1.
CCDSiCCDS50121.1.
RefSeqiNP_001013789.1. NM_001013767.2.
UniGeneiMm.426026.

3D structure databases

ProteinModelPortaliQ6J756.
SMRiQ6J756.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113132.

Protein family/group databases

MEROPSiC02.013.

PTM databases

iPTMnetiQ6J756.
PhosphoSitePlusiQ6J756.

Proteomic databases

PaxDbiQ6J756.
PRIDEiQ6J756.

Protocols and materials databases

DNASUi268958.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120717; ENSMUSP00000113132; ENSMUSG00000058626.
GeneIDi268958.
KEGGimmu:268958.
UCSCiuc008crh.1. mouse.

Organism-specific databases

CTDi11131.
MGIiMGI:1352490. Capn11.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ6J756.
KOiK08580.
OMAiEKHSESW.
OrthoDBiEOG091G049E.
PhylomeDBiQ6J756.
TreeFamiTF314748.

Enzyme and pathway databases

BRENDAi3.4.22.B31. 3474.

Miscellaneous databases

PROiQ6J756.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058626.
ExpressionAtlasiQ6J756. baseline and differential.
GenevisibleiQ6J756. MM.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN11_MOUSE
AccessioniPrimary (citable) accession number: Q6J756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.