Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6J4K2

- NCKX6_HUMAN

UniProt

Q6J4K2 - NCKX6_HUMAN

Protein

Sodium/potassium/calcium exchanger 6, mitochondrial

Gene

SLC8B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (10 Jan 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange. In contrast to other members of the family its function is independent of K+.4 Publications

    Enzyme regulationi

    Strongly inhibited by zinc.

    GO - Molecular functioni

    1. calcium:sodium antiporter activity Source: UniProtKB

    GO - Biological processi

    1. glucose homeostasis Source: UniProtKB
    2. ion transport Source: Reactome
    3. mitochondrial calcium ion transport Source: UniProtKB
    4. regulation of insulin secretion Source: UniProtKB
    5. response to stimulus Source: UniProtKB-KW
    6. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Antiport, Calcium transport, Ion transport, Sensory transduction, Sodium transport, Transport

    Keywords - Ligandi

    Calcium, Lithium, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_19320. Sodium/Calcium exchangers.

    Protein family/group databases

    TCDBi2.A.19.4.4. the ca(2+):cation antiporter (caca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium/calcium exchanger 6, mitochondrial
    Alternative name(s):
    Na(+)/K(+)/Ca(2+)-exchange protein 6
    Sodium/calcium exchanger protein, mitochondrial
    Solute carrier family 24 member 6
    Solute carrier family 8 member B1
    Gene namesi
    Name:SLC8B1
    Synonyms:NCKX6, NCLX, SLC24A6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:26175. SLC8B1.

    Subcellular locationi

    Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Mainly localizes to mitochondrion inner membrane.

    GO - Cellular componenti

    1. integral component of mitochondrial membrane Source: UniProtKB
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: Reactome
    4. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134954965.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
    BLAST
    Chaini27 – 584558Sodium/potassium/calcium exchanger 6, mitochondrialPRO_0000045756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ6J4K2.
    PaxDbiQ6J4K2.
    PRIDEiQ6J4K2.

    PTM databases

    PhosphoSiteiQ6J4K2.

    Expressioni

    Tissue specificityi

    Present in pancreatic beta-cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ6J4K2.
    BgeeiQ6J4K2.
    CleanExiHS_SLC24A6.
    GenevestigatoriQ6J4K2.

    Organism-specific databases

    HPAiHPA040668.

    Interactioni

    Protein-protein interaction databases

    BioGridi123078. 1 interaction.
    IntActiQ6J4K2. 1 interaction.
    STRINGi9606.ENSP00000202831.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6J4K2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 9569ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini117 – 14024CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 1687ExtracellularSequence Analysis
    Topological domaini190 – 20011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini222 – 2265ExtracellularSequence Analysis
    Topological domaini248 – 32578CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini347 – 36014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 3832CytoplasmicSequence Analysis
    Topological domaini405 – 41612ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini438 – 4458CytoplasmicSequence Analysis
    Topological domaini467 – 48721ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini509 – 52416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini546 – 55813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini580 – 5845CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei96 – 11621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei384 – 40421Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei488 – 50821Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei525 – 54521Helical; Name=12Sequence AnalysisAdd
    BLAST
    Transmembranei559 – 57921Helical; Name=13Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0530.
    HOGENOMiHOG000113743.
    HOVERGENiHBG082009.
    InParanoidiQ6J4K2.
    KOiK13754.
    OMAiDRVSSNT.
    OrthoDBiEOG7M0NRK.
    PhylomeDBiQ6J4K2.
    TreeFamiTF323444.

    Family and domain databases

    InterProiIPR004837. NaCa_Exmemb.
    [Graphical view]
    PfamiPF01699. Na_Ca_ex. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6J4K2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV    50
    VDCRKVCGLN VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV 100
    TLYVSWLLYL FLILGVTAAK FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG 150
    APDIFSALVA FSDPHTAGLA LGALFGAGVL VTTVVAGGIT ILHPFMAASR 200
    PFFRDIVFYM VAVFLTFLML FRGRVTLAWA LGYLGLYVFY VVTVILCTWI 250
    YQRQRRGSLF CPMPVTPEIL SDSEEDRVSS NTNSYDYGDE YRPLFFYQET 300
    TAQILVRALN PLDYMKWRRK SAYWKALKVF KLPVEFLLLL TVPVVDPDKD 350
    DQNWKRPLNC LHLVISPLVV VLTLQSGTYG VYEIGGLVPV WVVVVIAGTA 400
    LASVTFFATS DSQPPRLHWL FAFLGFLTSA LWINAAATEV VNILRSLGVV 450
    FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR QGYPRMAFSA CFGGIIFNIL 500
    VGVGLGCLLQ ISRSHTEVKL EPDGLLVWVL AGALGLSLVF SLVSVPLQCF 550
    QLSRVYGFCL LLFYLNFLVV ALLTEFGVIH LKSM 584
    Length:584
    Mass (Da):64,231
    Last modified:January 10, 2006 - v2
    Checksum:i6B7008661CC12872
    GO
    Isoform 2 (identifier: Q6J4K2-2) [UniParc]FASTAAdd to Basket

    Also known as: S-NCLX

    The sequence of this isoform differs from the canonical sequence as follows:
         176-231: Missing.

    Show »
    Length:528
    Mass (Da):58,087
    Checksum:iA1B30D288E0B7B47
    GO

    Sequence cautioni

    The sequence BAB15271.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571C → R in AAT35807. (PubMed:15060069)Curated
    Sequence conflicti130 – 1301S → P in AAT35807. (PubMed:15060069)Curated
    Sequence conflicti281 – 2811N → S in AAT35807. (PubMed:15060069)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti222 – 2221R → C.
    Corresponds to variant rs16942745 [ dbSNP | Ensembl ].
    VAR_050224
    Natural varianti358 – 3581L → F.
    Corresponds to variant rs3764034 [ dbSNP | Ensembl ].
    VAR_050225

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei176 – 23156Missing in isoform 2. 1 PublicationVSP_016996Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY601759 mRNA. Translation: AAT35807.1.
    AY601760 mRNA. Translation: AAT35808.1.
    AC010178 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98050.1.
    BC098360 mRNA. Translation: AAH98360.1.
    AK025886 mRNA. Translation: BAB15271.1. Different initiation.
    CCDSiCCDS31909.1. [Q6J4K2-1]
    RefSeqiNP_079235.2. NM_024959.2. [Q6J4K2-1]
    XP_006719670.1. XM_006719607.1.
    XP_006719671.1. XM_006719608.1. [Q6J4K2-1]
    UniGeneiHs.286194.

    Genome annotation databases

    EnsembliENST00000202831; ENSP00000202831; ENSG00000089060. [Q6J4K2-1]
    ENST00000546737; ENSP00000450081; ENSG00000089060. [Q6J4K2-2]
    ENST00000552014; ENSP00000447091; ENSG00000089060. [Q6J4K2-1]
    GeneIDi80024.
    KEGGihsa:80024.
    UCSCiuc001tvb.3. human. [Q6J4K2-1]

    Polymorphism databases

    DMDMi85681048.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY601759 mRNA. Translation: AAT35807.1 .
    AY601760 mRNA. Translation: AAT35808.1 .
    AC010178 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW98050.1 .
    BC098360 mRNA. Translation: AAH98360.1 .
    AK025886 mRNA. Translation: BAB15271.1 . Different initiation.
    CCDSi CCDS31909.1. [Q6J4K2-1 ]
    RefSeqi NP_079235.2. NM_024959.2. [Q6J4K2-1 ]
    XP_006719670.1. XM_006719607.1.
    XP_006719671.1. XM_006719608.1. [Q6J4K2-1 ]
    UniGenei Hs.286194.

    3D structure databases

    ProteinModelPortali Q6J4K2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123078. 1 interaction.
    IntActi Q6J4K2. 1 interaction.
    STRINGi 9606.ENSP00000202831.

    Protein family/group databases

    TCDBi 2.A.19.4.4. the ca(2+):cation antiporter (caca) family.

    PTM databases

    PhosphoSitei Q6J4K2.

    Polymorphism databases

    DMDMi 85681048.

    Proteomic databases

    MaxQBi Q6J4K2.
    PaxDbi Q6J4K2.
    PRIDEi Q6J4K2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000202831 ; ENSP00000202831 ; ENSG00000089060 . [Q6J4K2-1 ]
    ENST00000546737 ; ENSP00000450081 ; ENSG00000089060 . [Q6J4K2-2 ]
    ENST00000552014 ; ENSP00000447091 ; ENSG00000089060 . [Q6J4K2-1 ]
    GeneIDi 80024.
    KEGGi hsa:80024.
    UCSCi uc001tvb.3. human. [Q6J4K2-1 ]

    Organism-specific databases

    CTDi 80024.
    GeneCardsi GC12M113741.
    H-InvDB HIX0171623.
    HGNCi HGNC:26175. SLC8B1.
    HPAi HPA040668.
    MIMi 609841. gene.
    neXtProti NX_Q6J4K2.
    PharmGKBi PA134954965.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0530.
    HOGENOMi HOG000113743.
    HOVERGENi HBG082009.
    InParanoidi Q6J4K2.
    KOi K13754.
    OMAi DRVSSNT.
    OrthoDBi EOG7M0NRK.
    PhylomeDBi Q6J4K2.
    TreeFami TF323444.

    Enzyme and pathway databases

    Reactomei REACT_19320. Sodium/Calcium exchangers.

    Miscellaneous databases

    GenomeRNAii 80024.
    NextBioi 70174.
    PROi Q6J4K2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6J4K2.
    Bgeei Q6J4K2.
    CleanExi HS_SLC24A6.
    Genevestigatori Q6J4K2.

    Family and domain databases

    InterProi IPR004837. NaCa_Exmemb.
    [Graphical view ]
    Pfami PF01699. Na_Ca_ex. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger."
      Palty R., Ohana E., Hershfinkel M., Volokita M., Elgazar V., Beharier O., Silverman W.F., Argaman M., Sekler I.
      J. Biol. Chem. 279:25234-25240(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-584 (ISOFORM 1).
    6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic beta-cells."
      Tarasov A.I., Semplici F., Ravier M.A., Bellomo E.A., Pullen T.J., Gilon P., Sekler I., Rizzuto R., Rutter G.A.
      PLoS ONE 7:E39722-E39722(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "The mitochondrial na(+)/ca(2+) exchanger upregulates glucose dependent ca(2+) signalling linked to insulin secretion."
      Nita I.I., Hershfinkel M., Fishman D., Ozeri E., Rutter G.A., Sensi S.L., Khananshvili D., Lewis E.C., Sekler I.
      PLoS ONE 7:E46649-E46649(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNCKX6_HUMAN
    AccessioniPrimary (citable) accession number: Q6J4K2
    Secondary accession number(s): A6NP50
    , Q4KMS9, Q6J4K1, Q9H6I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: January 10, 2006
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3