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Q6J4K2

- NCKX6_HUMAN

UniProt

Q6J4K2 - NCKX6_HUMAN

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Protein

Sodium/potassium/calcium exchanger 6, mitochondrial

Gene

SLC8B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange. In contrast to other members of the family its function is independent of K+.4 Publications

Enzyme regulationi

Strongly inhibited by zinc.

GO - Molecular functioni

  1. calcium:sodium antiporter activity Source: UniProtKB
  2. calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Source: BHF-UCL
  3. protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  1. cytosolic calcium ion homeostasis Source: BHF-UCL
  2. glucose homeostasis Source: UniProtKB
  3. ion transport Source: Reactome
  4. mitochondrial calcium ion homeostasis Source: BHF-UCL
  5. mitochondrial calcium ion transport Source: UniProtKB
  6. regulation of cardiac muscle cell membrane potential Source: BHF-UCL
  7. regulation of insulin secretion Source: UniProtKB
  8. response to stimulus Source: UniProtKB-KW
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Sensory transduction, Sodium transport, Transport

Keywords - Ligandi

Calcium, Lithium, Sodium

Enzyme and pathway databases

ReactomeiREACT_19320. Sodium/Calcium exchangers.

Protein family/group databases

TCDBi2.A.19.4.4. the ca(2+):cation antiporter (caca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium/calcium exchanger 6, mitochondrial
Alternative name(s):
Na(+)/K(+)/Ca(2+)-exchange protein 6
Sodium/calcium exchanger protein, mitochondrial
Solute carrier family 24 member 6
Solute carrier family 8 member B1
Gene namesi
Name:SLC8B1
Synonyms:NCKX6, NCLX, SLC24A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:26175. SLC8B1.

Subcellular locationi

Mitochondrion inner membrane; Multi-pass membrane protein. Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Mainly localizes to mitochondrion inner membrane.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 9569ExtracellularSequence AnalysisAdd
BLAST
Transmembranei96 – 11621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini117 – 14024CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini162 – 1687ExtracellularSequence Analysis
Transmembranei169 – 18921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini190 – 20011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini222 – 2265ExtracellularSequence Analysis
Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini248 – 32578CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei326 – 34621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini347 – 36014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei361 – 38121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini382 – 3832CytoplasmicSequence Analysis
Transmembranei384 – 40421Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini405 – 41612ExtracellularSequence AnalysisAdd
BLAST
Transmembranei417 – 43721Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini438 – 4458CytoplasmicSequence Analysis
Transmembranei446 – 46621Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini467 – 48721ExtracellularSequence AnalysisAdd
BLAST
Transmembranei488 – 50821Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini509 – 52416CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei525 – 54521Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini546 – 55813ExtracellularSequence AnalysisAdd
BLAST
Transmembranei559 – 57921Helical; Name=13Sequence AnalysisAdd
BLAST
Topological domaini580 – 5845CytoplasmicSequence Analysis

GO - Cellular componenti

  1. integral component of mitochondrial membrane Source: UniProtKB
  2. mitochondrial crista Source: BHF-UCL
  3. plasma membrane Source: Reactome
  4. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134954965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2626MitochondrionSequence AnalysisAdd
BLAST
Chaini27 – 584558Sodium/potassium/calcium exchanger 6, mitochondrialPRO_0000045756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6J4K2.
PaxDbiQ6J4K2.
PRIDEiQ6J4K2.

PTM databases

PhosphoSiteiQ6J4K2.

Expressioni

Tissue specificityi

Present in pancreatic beta-cells (at protein level).1 Publication

Gene expression databases

BgeeiQ6J4K2.
CleanExiHS_SLC24A6.
ExpressionAtlasiQ6J4K2. baseline and differential.
GenevestigatoriQ6J4K2.

Organism-specific databases

HPAiHPA040668.

Interactioni

Protein-protein interaction databases

BioGridi123078. 1 interaction.
IntActiQ6J4K2. 1 interaction.
STRINGi9606.ENSP00000202831.

Structurei

3D structure databases

ProteinModelPortaliQ6J4K2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0530.
GeneTreeiENSGT00760000119209.
HOGENOMiHOG000113743.
HOVERGENiHBG082009.
InParanoidiQ6J4K2.
KOiK13754.
OMAiDRVSSNT.
OrthoDBiEOG7M0NRK.
PhylomeDBiQ6J4K2.
TreeFamiTF323444.

Family and domain databases

InterProiIPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6J4K2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV
60 70 80 90 100
VDCRKVCGLN VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV
110 120 130 140 150
TLYVSWLLYL FLILGVTAAK FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG
160 170 180 190 200
APDIFSALVA FSDPHTAGLA LGALFGAGVL VTTVVAGGIT ILHPFMAASR
210 220 230 240 250
PFFRDIVFYM VAVFLTFLML FRGRVTLAWA LGYLGLYVFY VVTVILCTWI
260 270 280 290 300
YQRQRRGSLF CPMPVTPEIL SDSEEDRVSS NTNSYDYGDE YRPLFFYQET
310 320 330 340 350
TAQILVRALN PLDYMKWRRK SAYWKALKVF KLPVEFLLLL TVPVVDPDKD
360 370 380 390 400
DQNWKRPLNC LHLVISPLVV VLTLQSGTYG VYEIGGLVPV WVVVVIAGTA
410 420 430 440 450
LASVTFFATS DSQPPRLHWL FAFLGFLTSA LWINAAATEV VNILRSLGVV
460 470 480 490 500
FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR QGYPRMAFSA CFGGIIFNIL
510 520 530 540 550
VGVGLGCLLQ ISRSHTEVKL EPDGLLVWVL AGALGLSLVF SLVSVPLQCF
560 570 580
QLSRVYGFCL LLFYLNFLVV ALLTEFGVIH LKSM
Length:584
Mass (Da):64,231
Last modified:January 10, 2006 - v2
Checksum:i6B7008661CC12872
GO
Isoform 2 (identifier: Q6J4K2-2) [UniParc]FASTAAdd to Basket

Also known as: S-NCLX

The sequence of this isoform differs from the canonical sequence as follows:
     176-231: Missing.

Show »
Length:528
Mass (Da):58,087
Checksum:iA1B30D288E0B7B47
GO

Sequence cautioni

The sequence BAB15271.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571C → R in AAT35807. (PubMed:15060069)Curated
Sequence conflicti130 – 1301S → P in AAT35807. (PubMed:15060069)Curated
Sequence conflicti281 – 2811N → S in AAT35807. (PubMed:15060069)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti222 – 2221R → C.
Corresponds to variant rs16942745 [ dbSNP | Ensembl ].
VAR_050224
Natural varianti358 – 3581L → F.
Corresponds to variant rs3764034 [ dbSNP | Ensembl ].
VAR_050225

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 23156Missing in isoform 2. 1 PublicationVSP_016996Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601759 mRNA. Translation: AAT35807.1.
AY601760 mRNA. Translation: AAT35808.1.
AC010178 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98050.1.
BC098360 mRNA. Translation: AAH98360.1.
AK025886 mRNA. Translation: BAB15271.1. Different initiation.
CCDSiCCDS31909.1. [Q6J4K2-1]
RefSeqiNP_079235.2. NM_024959.2. [Q6J4K2-1]
XP_006719670.1. XM_006719607.1.
XP_006719671.1. XM_006719608.1. [Q6J4K2-1]
UniGeneiHs.286194.

Genome annotation databases

EnsembliENST00000202831; ENSP00000202831; ENSG00000089060. [Q6J4K2-1]
ENST00000546737; ENSP00000450081; ENSG00000089060. [Q6J4K2-2]
ENST00000552014; ENSP00000447091; ENSG00000089060. [Q6J4K2-1]
GeneIDi80024.
KEGGihsa:80024.
UCSCiuc001tvb.3. human. [Q6J4K2-1]

Polymorphism databases

DMDMi85681048.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601759 mRNA. Translation: AAT35807.1 .
AY601760 mRNA. Translation: AAT35808.1 .
AC010178 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW98050.1 .
BC098360 mRNA. Translation: AAH98360.1 .
AK025886 mRNA. Translation: BAB15271.1 . Different initiation.
CCDSi CCDS31909.1. [Q6J4K2-1 ]
RefSeqi NP_079235.2. NM_024959.2. [Q6J4K2-1 ]
XP_006719670.1. XM_006719607.1.
XP_006719671.1. XM_006719608.1. [Q6J4K2-1 ]
UniGenei Hs.286194.

3D structure databases

ProteinModelPortali Q6J4K2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123078. 1 interaction.
IntActi Q6J4K2. 1 interaction.
STRINGi 9606.ENSP00000202831.

Protein family/group databases

TCDBi 2.A.19.4.4. the ca(2+):cation antiporter (caca) family.

PTM databases

PhosphoSitei Q6J4K2.

Polymorphism databases

DMDMi 85681048.

Proteomic databases

MaxQBi Q6J4K2.
PaxDbi Q6J4K2.
PRIDEi Q6J4K2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000202831 ; ENSP00000202831 ; ENSG00000089060 . [Q6J4K2-1 ]
ENST00000546737 ; ENSP00000450081 ; ENSG00000089060 . [Q6J4K2-2 ]
ENST00000552014 ; ENSP00000447091 ; ENSG00000089060 . [Q6J4K2-1 ]
GeneIDi 80024.
KEGGi hsa:80024.
UCSCi uc001tvb.3. human. [Q6J4K2-1 ]

Organism-specific databases

CTDi 80024.
GeneCardsi GC12M113741.
H-InvDB HIX0171623.
HGNCi HGNC:26175. SLC8B1.
HPAi HPA040668.
MIMi 609841. gene.
neXtProti NX_Q6J4K2.
PharmGKBi PA134954965.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0530.
GeneTreei ENSGT00760000119209.
HOGENOMi HOG000113743.
HOVERGENi HBG082009.
InParanoidi Q6J4K2.
KOi K13754.
OMAi DRVSSNT.
OrthoDBi EOG7M0NRK.
PhylomeDBi Q6J4K2.
TreeFami TF323444.

Enzyme and pathway databases

Reactomei REACT_19320. Sodium/Calcium exchangers.

Miscellaneous databases

ChiTaRSi SLC8B1. human.
GenomeRNAii 80024.
NextBioi 70174.
PROi Q6J4K2.
SOURCEi Search...

Gene expression databases

Bgeei Q6J4K2.
CleanExi HS_SLC24A6.
ExpressionAtlasi Q6J4K2. baseline and differential.
Genevestigatori Q6J4K2.

Family and domain databases

InterProi IPR004837. NaCa_Exmemb.
[Graphical view ]
Pfami PF01699. Na_Ca_ex. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger."
    Palty R., Ohana E., Hershfinkel M., Volokita M., Elgazar V., Beharier O., Silverman W.F., Argaman M., Sekler I.
    J. Biol. Chem. 279:25234-25240(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION.
  2. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-584 (ISOFORM 1).
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic beta-cells."
    Tarasov A.I., Semplici F., Ravier M.A., Bellomo E.A., Pullen T.J., Gilon P., Sekler I., Rizzuto R., Rutter G.A.
    PLoS ONE 7:E39722-E39722(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "The mitochondrial na(+)/ca(2+) exchanger upregulates glucose dependent ca(2+) signalling linked to insulin secretion."
    Nita I.I., Hershfinkel M., Fishman D., Ozeri E., Rutter G.A., Sensi S.L., Khananshvili D., Lewis E.C., Sekler I.
    PLoS ONE 7:E46649-E46649(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiNCKX6_HUMAN
AccessioniPrimary (citable) accession number: Q6J4K2
Secondary accession number(s): A6NP50
, Q4KMS9, Q6J4K1, Q9H6I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: November 26, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3