Q6J4I5 (Q6J4I5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Sex-determining region Y protein PIRNR PIRNR037653

Gene names

Name:

SRY EMBL AAT39017.1

Organism

Homo sapiens (Human) EMBL AAT39017.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional regulator that controls a genetic switch in male development By similarity. PIRNR PIRNR037653
Sequence similarities	Belongs to the SRY family. PIRNR PIRNR037653 Contains 1 HMG box DNA-binding domain. SAAS SAAS017253

Ontologies

Keywords
Biological process	Differentiation Sexual differentiation PIRNR PIRNR037653 SAAS SAAS017253 Transcription Transcription regulation PIRNR PIRNR037653 SAAS SAAS017253
Cellular component	Nucleus PIRNR PIRNR037653 SAAS SAAS017253
Ligand	DNA-binding PIRNR PIRNR037653 SAAS SAAS017253
Molecular function	Activator PIRNR PIRNR037653 SAAS SAAS017253
Technical term	3D-structure PDB 2GZK
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW male sex determination Inferred from electronic annotation. Source: InterPro sex differentiation Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	198	1	EMBL AAT39017.1

Sequences

	Sequence		Length	Mass (Da)
	Q6J4I5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7194FF16A21BE3F7	FASTA	198	22,991
	10 20 30 40 50 60 MQSYASAMLS VFNSDYYSPA PQENIPALRR SSSFLCTESC NSKYQCETGE NSKGNVQDRV 70 80 90 100 110 120 KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM LTEAEKWPFF QEAQKLQAMH 130 140 150 160 170 180 REKYPNYKYR PRRKAKMLPK NCSLLPADPA SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL 190 GHLPPINAAA HRATGPLQ

References

[1]	"Fate of SRY, PABY, DYS1, DYZ3 and DYZ1 loci in Indian patients harbouring sex chromosomal anomalies." Bashamboo A., Rahman M.M., Prasad A., Chandy S.P., Ahmad J., Ali S. Mol. Hum. Reprod. 11:117-127(2005) [PubMed: 15579656] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SAP20SRY EMBL AAT39017.1.
[2]	"Structure of a complex of tandem HMG boxes and DNA." Stott K., Tang G.S., Lee K.B., Thomas J.O. J. Mol. Biol. 360:90-104(2006) [PubMed: 16813837] [Abstract] Cited for: STRUCTURE BY NMR OF 56-130.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY601858 Genomic DNA. Translation: AAT39017.1.

IPI

IPI01012788.

UniGene

Hs.1992.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GZK	NMR	-	A	56-130	[»]

ProteinModelPortal

Q6J4I5.

ModBase

Search...

Protein-protein interaction databases

STRING

Q6J4I5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG008712.

Gene expression databases

ArrayExpress

Q6J4I5.

Family and domain databases

InterPro

IPR000910. HMG_HMG1/HMG2.
IPR009071. HMG_superfamily.
IPR017253. TF_Sry.
[Graphical view]

Gene3D

G3DSA:1.10.30.10. HMG-box. 1 hit.

PANTHER

PTHR10270:SF48. PTHR10270:SF48. 1 hit.

Pfam

PF00505. HMG_box. 1 hit.
[Graphical view]

PIRSF

PIRSF037653. SRY. 1 hit.

SMART

SM00398. HMG. 1 hit.
[Graphical view]

SUPFAM

SSF47095. HMG-box. 1 hit.

PROSITE

PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q6J4I5_HUMAN

Accession

Primary (citable) accession number: Q6J4I5

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.