Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 1 regulatory subunit 1B

Gene

Ppp1r1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.By similarity

GO - Molecular functioni

  • D1 dopamine receptor binding Source: RGD
  • D2 dopamine receptor binding Source: RGD
  • D3 dopamine receptor binding Source: RGD
  • D4 dopamine receptor binding Source: RGD
  • D5 dopamine receptor binding Source: RGD
  • protein phosphatase inhibitor activity Source: RGD
  • protein serine/threonine phosphatase inhibitor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-180024. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1B
Alternative name(s):
DARPP-32
Dopamine- and cAMP-regulated neuronal phosphoprotein
Gene namesi
Name:Ppp1r1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621859. Ppp1r1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Protein phosphatase 1 regulatory subunit 1BPRO_0000286442Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei34 – 341Phosphothreonine; by PKABy similarity
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei46 – 461PhosphoserineCombined sources
Modified residuei75 – 751Phosphothreonine; by CDK5By similarity
Modified residuei102 – 1021PhosphoserineCombined sources
Modified residuei137 – 1371PhosphoserineCombined sources

Post-translational modificationi

Phosphorylation of Thr-34 is required for activity.By similarity
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6J4I0.
PRIDEiQ6J4I0.

PTM databases

iPTMnetiQ6J4I0.
PhosphoSiteiQ6J4I0.

Expressioni

Gene expression databases

BgeeiENSRNOG00000028404.
GenevisibleiQ6J4I0. RN.

Interactioni

GO - Molecular functioni

  • D1 dopamine receptor binding Source: RGD
  • D2 dopamine receptor binding Source: RGD
  • D3 dopamine receptor binding Source: RGD
  • D4 dopamine receptor binding Source: RGD
  • D5 dopamine receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034614.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J1BH. Eukaryota.
ENOG4111TN1. LUCA.
GeneTreeiENSGT00730000111283.
HOGENOMiHOG000290193.
HOVERGENiHBG099182.
InParanoidiQ6J4I0.
KOiK15494.
OMAiPAMLFRV.
OrthoDBiEOG091G0NO6.
PhylomeDBiQ6J4I0.
TreeFamiTF332576.

Family and domain databases

InterProiIPR015670. DARPP-32.
IPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PTHR15417:SF2. PTHR15417:SF2. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6J4I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPALLFR VSEHSSPEEE
60 70 80 90 100
SSPHQRTSGE GHHPKSKRPN PCAYTPPSLK AVQRIAESHL QTISNLSENQ
110 120 130 140 150
ASEEEDELGE LRELGYPQED DEEDEDEDEE EDEEEDSQAE VLKGSRGTAG
160 170 180 190 200
QKLTSGQGLE GPWERPPPLD EPQRDGNSED QGEGRATQSE PGEEPRHPTP

PESGT
Length:205
Mass (Da):22,913
Last modified:July 5, 2004 - v1
Checksum:i38B587BFEBAC692A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601872 mRNA. Translation: AAT11858.1.
BC078954 mRNA. Translation: AAH78954.1.
RefSeqiNP_612530.1. NM_138521.1.
UniGeneiRn.70366.

Genome annotation databases

EnsembliENSRNOT00000037752; ENSRNOP00000034614; ENSRNOG00000028404.
GeneIDi360616.
KEGGirno:360616.
UCSCiRGD:621859. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY601872 mRNA. Translation: AAT11858.1.
BC078954 mRNA. Translation: AAH78954.1.
RefSeqiNP_612530.1. NM_138521.1.
UniGeneiRn.70366.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034614.

PTM databases

iPTMnetiQ6J4I0.
PhosphoSiteiQ6J4I0.

Proteomic databases

PaxDbiQ6J4I0.
PRIDEiQ6J4I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037752; ENSRNOP00000034614; ENSRNOG00000028404.
GeneIDi360616.
KEGGirno:360616.
UCSCiRGD:621859. rat.

Organism-specific databases

CTDi84152.
RGDi621859. Ppp1r1b.

Phylogenomic databases

eggNOGiENOG410J1BH. Eukaryota.
ENOG4111TN1. LUCA.
GeneTreeiENSGT00730000111283.
HOGENOMiHOG000290193.
HOVERGENiHBG099182.
InParanoidiQ6J4I0.
KOiK15494.
OMAiPAMLFRV.
OrthoDBiEOG091G0NO6.
PhylomeDBiQ6J4I0.
TreeFamiTF332576.

Enzyme and pathway databases

ReactomeiR-RNO-180024. DARPP-32 events.

Miscellaneous databases

PROiQ6J4I0.

Gene expression databases

BgeeiENSRNOG00000028404.
GenevisibleiQ6J4I0. RN.

Family and domain databases

InterProiIPR015670. DARPP-32.
IPR008466. PPP1R1A/B/C.
[Graphical view]
PANTHERiPTHR15417. PTHR15417. 1 hit.
PTHR15417:SF2. PTHR15417:SF2. 1 hit.
PfamiPF05395. DARPP-32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR1B_RAT
AccessioniPrimary (citable) accession number: Q6J4I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.