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Protein

Solute carrier family 25 member 47

Gene

Slc25a47

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Uncoupling protein which may catalyze the physiological 'proton leak' in liver.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 47
Alternative name(s):
Hepatocellular carcinoma down-regulated mitochondrial carrier homolog
Gene namesi
Name:Slc25a47
Synonyms:Hdmcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1303247. Slc25a47.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei98 – 11619Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei192 – 21221Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei219 – 23921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Solute carrier family 25 member 47PRO_0000291781Add
BLAST

Proteomic databases

PaxDbiQ6J329.
PRIDEiQ6J329.

Structurei

3D structure databases

ProteinModelPortaliQ6J329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 8080Solcar 1Add
BLAST
Repeati93 – 208116Solcar 2Add
BLAST
Repeati217 – 30488Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0762. Eukaryota.
ENOG410Z9ZS. LUCA.
GeneTreeiENSGT00700000104295.
HOVERGENiHBG003500.
InParanoidiQ6J329.
KOiK15123.
OMAiHCLAHIC.
OrthoDBiEOG77DJ6R.
PhylomeDBiQ6J329.
TreeFamiTF351739.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6J329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFVAGAIGG VCGVAVGYPL DTVKVKIQTE AKYTSIWHCV RDTYRQERLW
60 70 80 90 100
GFYRGLSLPV CTVSLVSSVS FGTYHHCLAH ICRFRYGSTD VKPTKADITL
110 120 130 140 150
SGCASGLVRV FLTSPTEVAK VRLQTQAQSQ TQQRRPSASW TSVAPALCPA
160 170 180 190 200
PTACLEPRPK YSGPLHCLVT VAREEGLRGL YKGSSALLLR EGHSFATYFL
210 220 230 240 250
SYAVLSEWLT PAGQSQPDVL GVLVAGGCAG VLAWAVATPM DVIKSRLQAD
260 270 280 290 300
GQGQQRYRGL LHCVVTSVRE EGPRVLFKGL ALNCCRAFPV NMVVFVAYEA
310
VLRLTQGLLT
Length:310
Mass (Da):33,618
Last modified:July 5, 2004 - v1
Checksum:i9CFB1B6DC9B5C93A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603424 mRNA. Translation: AAT35561.1.
BC089874 mRNA. Translation: AAH89874.1.
RefSeqiNP_001001509.1. NM_001001509.1.
UniGeneiRn.109623.

Genome annotation databases

EnsembliENSRNOT00000004070; ENSRNOP00000004070; ENSRNOG00000003020.
GeneIDi299316.
KEGGirno:299316.
UCSCiRGD:1303247. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603424 mRNA. Translation: AAT35561.1.
BC089874 mRNA. Translation: AAH89874.1.
RefSeqiNP_001001509.1. NM_001001509.1.
UniGeneiRn.109623.

3D structure databases

ProteinModelPortaliQ6J329.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ6J329.
PRIDEiQ6J329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004070; ENSRNOP00000004070; ENSRNOG00000003020.
GeneIDi299316.
KEGGirno:299316.
UCSCiRGD:1303247. rat.

Organism-specific databases

CTDi283600.
RGDi1303247. Slc25a47.

Phylogenomic databases

eggNOGiKOG0762. Eukaryota.
ENOG410Z9ZS. LUCA.
GeneTreeiENSGT00700000104295.
HOVERGENiHBG003500.
InParanoidiQ6J329.
KOiK15123.
OMAiHCLAHIC.
OrthoDBiEOG77DJ6R.
PhylomeDBiQ6J329.
TreeFamiTF351739.

Miscellaneous databases

NextBioi645213.
PROiQ6J329.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein."
    Tan M.G.K., Ooi L.L.P.J., Aw S.E., Hui K.M.
    J. Biol. Chem. 279:45235-45244(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiS2547_RAT
AccessioniPrimary (citable) accession number: Q6J329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.