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Protein

E3 ubiquitin-protein ligase RNF114

Gene

Rnf114

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri30 – 6940RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ligase

Keywords - Biological processi

Differentiation, Spermatogenesis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF114 (EC:6.3.2.-)
Alternative name(s):
RING finger protein 114
Zinc finger protein 313
Gene namesi
Name:Rnf114
Synonyms:Zfp313, Znf313
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1303139. Rnf114.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229E3 ubiquitin-protein ligase RNF114PRO_0000056311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031N6-acetyllysineBy similarity
Modified residuei113 – 1131N6-acetyllysineBy similarity

Post-translational modificationi

Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

PaxDbiQ6J2U6.
PRIDEiQ6J2U6.

PTM databases

iPTMnetiQ6J2U6.

Expressioni

Gene expression databases

GenevisibleiQ6J2U6. RN.

Interactioni

Subunit structurei

Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012675.

Structurei

3D structure databases

ProteinModelPortaliQ6J2U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri30 – 6940RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEG7. Eukaryota.
ENOG4111JWC. LUCA.
GeneTreeiENSGT00530000063064.
HOGENOMiHOG000230946.
HOVERGENiHBG074331.
InParanoidiQ6J2U6.
KOiK15697.
OMAiIEHIQRR.
OrthoDBiEOG7VDXQ7.
PhylomeDBiQ6J2U6.
TreeFamiTF331012.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008598. Di19_Zn_binding_dom.
IPR027370. Znf-RING_LisH.
IPR015880. Znf_C2H2-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF05605. zf-Di19. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6J2U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAQPESRD GAAQSAKPAS ETDPLSRFTC PVCLEVFEKP VQVPCGHVFC
60 70 80 90 100
SACLQECLKP KKPVCGVCRS ALAPGVRAAE LERQIESIET SCHGCRKDFV
110 120 130 140 150
LSKIRAHVAS CSKYQSYIME GVKATTKDAS LQQRNVPNRY TFPCPYCPEK
160 170 180 190 200
NFDQEGLVEH CKLTHSTDTK SVVCPICASM PWGDPSYRSA NFMEHIQRRH
210 220
RFSYDTFVDY DVDEDDMINQ VLQRSIIDQ
Length:229
Mass (Da):25,664
Last modified:July 5, 2004 - v1
Checksum:i72DB48DF7FE1B900
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603473 mRNA. Translation: AAT28739.1.
BC098633 mRNA. Translation: AAH98633.1.
RefSeqiNP_001001517.1. NM_001001517.1.
UniGeneiRn.49925.

Genome annotation databases

EnsembliENSRNOT00000086459; ENSRNOP00000068785; ENSRNOG00000060821.
GeneIDi362277.
KEGGirno:362277.
UCSCiRGD:1303139. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603473 mRNA. Translation: AAT28739.1.
BC098633 mRNA. Translation: AAH98633.1.
RefSeqiNP_001001517.1. NM_001001517.1.
UniGeneiRn.49925.

3D structure databases

ProteinModelPortaliQ6J2U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012675.

PTM databases

iPTMnetiQ6J2U6.

Proteomic databases

PaxDbiQ6J2U6.
PRIDEiQ6J2U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000086459; ENSRNOP00000068785; ENSRNOG00000060821.
GeneIDi362277.
KEGGirno:362277.
UCSCiRGD:1303139. rat.

Organism-specific databases

CTDi55905.
RGDi1303139. Rnf114.

Phylogenomic databases

eggNOGiENOG410IEG7. Eukaryota.
ENOG4111JWC. LUCA.
GeneTreeiENSGT00530000063064.
HOGENOMiHOG000230946.
HOVERGENiHBG074331.
InParanoidiQ6J2U6.
KOiK15697.
OMAiIEHIQRR.
OrthoDBiEOG7VDXQ7.
PhylomeDBiQ6J2U6.
TreeFamiTF331012.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi679307.
PROiQ6J2U6.

Gene expression databases

GenevisibleiQ6J2U6. RN.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR008598. Di19_Zn_binding_dom.
IPR027370. Znf-RING_LisH.
IPR015880. Znf_C2H2-like.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF05605. zf-Di19. 1 hit.
PF13445. zf-RING_UBOX. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of rat Znf313 gene."
    Ma Y.-X., Wu Q., Zhang S., Li N., Sun Y., Peng Y., He G., Liu Y., Dong J.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiRN114_RAT
AccessioniPrimary (citable) accession number: Q6J2U6
Secondary accession number(s): Q4G096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.