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Q6J1T3 (MT_SCYTO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Metallothionein
Short name=MT
Gene names
Name:mt
OrganismScyliorhinus torazame (Cloudy catshark)
Taxonomic identifier75743 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Galeoidea › Carcharhiniformes › Scyliorhinidae › Scyliorhinus

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6868Metallothionein
PRO_0000197319

Sites

Metal binding71Divalent metal cation; cluster B By similarity
Metal binding91Divalent metal cation; cluster B By similarity
Metal binding141Divalent metal cation; cluster B By similarity
Metal binding161Divalent metal cation; cluster B By similarity
Metal binding201Divalent metal cation; cluster B By similarity
Metal binding221Divalent metal cation; cluster B By similarity
Metal binding251Divalent metal cation; cluster B By similarity
Metal binding271Divalent metal cation; cluster B By similarity
Metal binding351Divalent metal cation; cluster B By similarity
Metal binding391Divalent metal cation; cluster A By similarity
Metal binding401Divalent metal cation; cluster A By similarity
Metal binding421Divalent metal cation; cluster A By similarity
Metal binding431Divalent metal cation; cluster A By similarity
Metal binding471Divalent metal cation; cluster A By similarity
Metal binding501Divalent metal cation; cluster A By similarity
Metal binding541Divalent metal cation; cluster A By similarity
Metal binding561Divalent metal cation; cluster A By similarity
Metal binding641Divalent metal cation; cluster A By similarity
Metal binding661Divalent metal cation; cluster A By similarity
Metal binding671Divalent metal cation; cluster A By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6J1T3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 048157EF8400A6A9

FASTA686,957
        10         20         30         40         50         60 
MSDTKPCVCL DGSCSCENTC RCSDCRCPTS KAGRCQKSCC SCCPAGCTNC ANGCVCKGKA 


SDKCSCCS

« Hide

References

[1]"Characterization of metallothionein cDNA and transcriptional response to heavy metal exposures in a shark species, Scyliorhinus torazame."
Nam Y.K., Kim D.S., Kim S.K., Kim K.H.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY605090 mRNA. Translation: AAT35554.1.

3D structure databases

ProteinModelPortalQ6J1T3.
SMRQ6J1T3. Positions 37-68.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009063.

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
SUPFAMSSF57868. Metallothionein_sfam. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT_SCYTO
AccessionPrimary (citable) accession number: Q6J1T3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: March 6, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

SIMILARITY comments

Index of protein domains and families

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