Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6J1T3

- MT_SCYTO

UniProt

Q6J1T3 - MT_SCYTO

Protein

Metallothionein

Gene

mt

Organism
Scyliorhinus torazame (Cloudy catshark)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71Divalent metal cation; cluster BBy similarity
    Metal bindingi9 – 91Divalent metal cation; cluster BBy similarity
    Metal bindingi14 – 141Divalent metal cation; cluster BBy similarity
    Metal bindingi16 – 161Divalent metal cation; cluster BBy similarity
    Metal bindingi20 – 201Divalent metal cation; cluster BBy similarity
    Metal bindingi22 – 221Divalent metal cation; cluster BBy similarity
    Metal bindingi25 – 251Divalent metal cation; cluster BBy similarity
    Metal bindingi27 – 271Divalent metal cation; cluster BBy similarity
    Metal bindingi35 – 351Divalent metal cation; cluster BBy similarity
    Metal bindingi39 – 391Divalent metal cation; cluster ABy similarity
    Metal bindingi40 – 401Divalent metal cation; cluster ABy similarity
    Metal bindingi42 – 421Divalent metal cation; cluster ABy similarity
    Metal bindingi43 – 431Divalent metal cation; cluster ABy similarity
    Metal bindingi47 – 471Divalent metal cation; cluster ABy similarity
    Metal bindingi50 – 501Divalent metal cation; cluster ABy similarity
    Metal bindingi54 – 541Divalent metal cation; cluster ABy similarity
    Metal bindingi56 – 561Divalent metal cation; cluster ABy similarity
    Metal bindingi64 – 641Divalent metal cation; cluster ABy similarity
    Metal bindingi66 – 661Divalent metal cation; cluster ABy similarity
    Metal bindingi67 – 671Divalent metal cation; cluster ABy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein
    Short name:
    MT
    Gene namesi
    Name:mt
    OrganismiScyliorhinus torazame (Cloudy catshark)
    Taxonomic identifieri75743 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiGaleomorphiiGaleoideaCarcharhiniformesScyliorhinidaeScyliorhinus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6868MetallothioneinPRO_0000197319Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6J1T3.
    SMRiQ6J1T3. Positions 37-68.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG009063.

    Family and domain databases

    Gene3Di4.10.10.10. 1 hit.
    InterProiIPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    [Graphical view]
    PANTHERiPTHR23299. PTHR23299. 1 hit.
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    SUPFAMiSSF57868. SSF57868. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6J1T3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTKPCVCL DGSCSCENTC RCSDCRCPTS KAGRCQKSCC SCCPAGCTNC   50
    ANGCVCKGKA SDKCSCCS 68
    Length:68
    Mass (Da):6,957
    Last modified:July 5, 2004 - v1
    Checksum:i048157EF8400A6A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY605090 mRNA. Translation: AAT35554.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY605090 mRNA. Translation: AAT35554.1 .

    3D structure databases

    ProteinModelPortali Q6J1T3.
    SMRi Q6J1T3. Positions 37-68.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG009063.

    Family and domain databases

    Gene3Di 4.10.10.10. 1 hit.
    InterProi IPR017854. Metalthion_dom.
    IPR023587. Metalthion_dom_vert.
    IPR003019. Metalthion_sfam_euk.
    IPR000006. Metalthion_vert.
    [Graphical view ]
    PANTHERi PTHR23299. PTHR23299. 1 hit.
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57868. SSF57868. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of metallothionein cDNA and transcriptional response to heavy metal exposures in a shark species, Scyliorhinus torazame."
      Nam Y.K., Kim D.S., Kim S.K., Kim K.H.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMT_SCYTO
    AccessioniPrimary (citable) accession number: Q6J1T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3