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Protein

Undifferentiated embryonic cell transcription factor 1

Gene

Utf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional coactivator of ATF2.1 Publication

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Undifferentiated embryonic cell transcription factor 1
Gene namesi
Name:Utf1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1276125. Utf1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Undifferentiated embryonic cell transcription factor 1PRO_0000274552Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151PhosphoserineCombined sources
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei48 – 481PhosphoserineCombined sources
Modified residuei54 – 541PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6J1H4.
PRIDEiQ6J1H4.

PTM databases

iPTMnetiQ6J1H4.
PhosphoSiteiQ6J1H4.

Expressioni

Tissue specificityi

Expressed mainly in pluripotent cells with expression rapidly down-regulated upon cell differentiation.1 Publication

Developmental stagei

First detected in the embryo at the blastocyst stage. Little or no expression detected in adult tissues.1 Publication

Gene expression databases

BgeeiQ6J1H4.
ExpressionAtlasiQ6J1H4. baseline and differential.
GenevisibleiQ6J1H4. MM.

Interactioni

Subunit structurei

Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.1 Publication

GO - Molecular functioni

  • HMG box domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi204468. 4 interactions.
STRINGi10090.ENSMUSP00000128848.

Structurei

3D structure databases

ProteinModelPortaliQ6J1H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni279 – 31032Leucine-zipperAdd
BLAST

Domaini

The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters.1 Publication

Phylogenomic databases

eggNOGiKOG4282. Eukaryota.
ENOG410YYXY. LUCA.
GeneTreeiENSGT00390000014419.
HOGENOMiHOG000060176.
HOVERGENiHBG094142.
InParanoidiQ6J1H4.
OMAiCRRRYKF.
OrthoDBiEOG7KWSJG.
PhylomeDBiQ6J1H4.
TreeFamiTF337319.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 11 Publication (identifier: Q6J1H4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLRPRRLPA FSPPSPASPD AELRSAGDVP VTTSDAFATS GGMAEPGSPK
60 70 80 90 100
APVSPDSAQR TPWSARETEL LLGTLLQPAM WRSLLLDRRQ TLPTYRRVSA
110 120 130 140 150
ALARQQVRRT PAQCRRRYKF LKDKLRDSQG QPSGPFDNQI RQLMGLLGDD
160 170 180 190 200
GPPRVRRRST GPGRPQRRGR SSLSALAPAP APVEQEAELP LAAENDEPAP
210 220 230 240 250
ALRFSSSTTK SAGAHRITSS PPLTSTDTLP PEPGHTFESS PTPTPDHDVE
260 270 280 290 300
TPNEPPGLSQ GRASSPQVAP QSLNTALLQT LTHLGDISTV LGPLRDQLST
310 320 330
LNQHVEHLRG SFDQTVSLAV GFILGSAASE RGILGDLRQ
Length:339
Mass (Da):36,408
Last modified:February 6, 2007 - v2
Checksum:i96AD8D6F8413F171
GO
Isoform 21 Publication (identifier: Q6J1H4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:297
Mass (Da):32,129
Checksum:iD1D5BA7EE8581B5D
GO

Sequence cautioni

The sequence AAT38948.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4242Missing in isoform 2. 1 PublicationVSP_052292Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31647 mRNA. Translation: BAA25403.1.
AB017360 Genomic DNA. Translation: BAA82667.1.
AY606111 mRNA. Translation: AAT38948.1. Different initiation.
CCDSiCCDS21958.1. [Q6J1H4-1]
PIRiJC7712.
RefSeqiNP_033508.1. NM_009482.2. [Q6J1H4-1]
UniGeneiMm.10205.

Genome annotation databases

EnsembliENSMUST00000168457; ENSMUSP00000128848; ENSMUSG00000047751. [Q6J1H4-1]
GeneIDi22286.
KEGGimmu:22286.
UCSCiuc009kgf.1. mouse. [Q6J1H4-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31647 mRNA. Translation: BAA25403.1.
AB017360 Genomic DNA. Translation: BAA82667.1.
AY606111 mRNA. Translation: AAT38948.1. Different initiation.
CCDSiCCDS21958.1. [Q6J1H4-1]
PIRiJC7712.
RefSeqiNP_033508.1. NM_009482.2. [Q6J1H4-1]
UniGeneiMm.10205.

3D structure databases

ProteinModelPortaliQ6J1H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204468. 4 interactions.
STRINGi10090.ENSMUSP00000128848.

PTM databases

iPTMnetiQ6J1H4.
PhosphoSiteiQ6J1H4.

Proteomic databases

PaxDbiQ6J1H4.
PRIDEiQ6J1H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000168457; ENSMUSP00000128848; ENSMUSG00000047751. [Q6J1H4-1]
GeneIDi22286.
KEGGimmu:22286.
UCSCiuc009kgf.1. mouse. [Q6J1H4-1]

Organism-specific databases

CTDi8433.
MGIiMGI:1276125. Utf1.

Phylogenomic databases

eggNOGiKOG4282. Eukaryota.
ENOG410YYXY. LUCA.
GeneTreeiENSGT00390000014419.
HOGENOMiHOG000060176.
HOVERGENiHBG094142.
InParanoidiQ6J1H4.
OMAiCRRRYKF.
OrthoDBiEOG7KWSJG.
PhylomeDBiQ6J1H4.
TreeFamiTF337319.

Miscellaneous databases

PROiQ6J1H4.
SOURCEiSearch...

Gene expression databases

BgeeiQ6J1H4.
ExpressionAtlasiQ6J1H4. baseline and differential.
GenevisibleiQ6J1H4. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells."
    Okuda A., Fukushima A., Nishimoto M., Orimo A., Yamagishi T., Nabeshima Y., Kuro-o M., Nabeshima Y., Boon K., Keaveney M., Stunnenberg H.G., Muramatsu M.
    EMBO J. 17:2019-2032(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ATF2 AND TBP, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION.
    Tissue: Teratocarcinoma1 Publication.
  2. "Structural analyses of the UTF1 gene encoding a transcriptional coactivator expressed in pluripotent embryonic stem cells."
    Nishimoto M., Fukushima A., Miyagi S., Suzuki Y., Sugano S., Matsuda Y., Hori T., Muramatsu M., Okuda A.
    Biochem. Biophys. Res. Commun. 285:945-953(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2).
    Strain: BALB/cJ1 Publication.
  3. "Mus musculus Melcg1 gene clone and function research."
    Xiang Y., Nie D.S., Lu G.X.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Carboxy-terminally truncated form of a coactivator UTF1 stimulates transcription from a variety of gene promoters through the TATA Box."
    Fukushima A., Nishimoto M., Okuda A., Muramatsu M.
    Biochem. Biophys. Res. Commun. 258:519-523(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: LEUCINE-ZIPPER DOMAIN.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-18; SER-48 AND SER-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiUTF1_MOUSE
AccessioniPrimary (citable) accession number: Q6J1H4
Secondary accession number(s): O70530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: June 8, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.