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Protein

Galactoside 2-alpha-L-fucosyltransferase

Gene

FUT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferaseUniRule annotation (EC:2.4.1.69UniRule annotation)
Gene namesi
Name:FUT1Imported
ORF Names:hCG_16221Imported
Encoded oniPlastidImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Golgi apparatusGolgi stack membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, PlastidImported

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28428.

PTM / Processingi

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000174951.
ExpressionAtlasiQ6IZA2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312021.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
HOVERGENiHBG004338.
KOiK00718.
OMAiFLHIHQD.
OrthoDBiEOG091G0X2P.
PhylomeDBiQ6IZA2.

Family and domain databases

InterProiView protein in InterPro
IPR002516. Glyco_trans_11.
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiView protein in Pfam
PF01531. Glyco_transf_11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6IZA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLRSHRQLC LAFLLVCVLS VIFFLHIHQD SFPHGLGLSI LCPDRRLVTP
60 70 80 90 100
PVAIFCLPGT AMGPNASSSC PQHPASLSGT WTVYPNGRFG NQMGQYATLL
110 120 130 140 150
ALAQLNGRRA FILPAMHAAL APVFRITLPV LAPEVDSRTP WRELQLHDWM
160 170 180 190 200
SEEYADLRDP FLKLSGFPCS WTFFHHLREQ IRREFTLHDH LREEAQSVLG
210 220 230 240 250
QLRLGRTGDR PRTFVGVHVR RGDYLQVMPQ RWKGVVGDSA YLRQAMDWFR
260 270 280 290 300
ARHEAPVFVV TSNGMEWCKE NIDTSQGDVT FAGDGQEATP WKDFALLTQC
310 320 330 340 350
NHTIMTIGTF GFWAAYLAGG DTVYLANFTL PDSEFLKIFK PEAAFLPEWV
360
GINADLSPLW TLAKP
Length:365
Mass (Da):41,251
Last modified:May 10, 2005 - v1
Checksum:i4F4442EC375C9D9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611628 Genomic DNA. Translation: AAT42242.1.
KF906450 Genomic DNA. Translation: AHJ09661.1.
FM180557 Genomic DNA. Translation: CAQ81977.1.
CH471177 Genomic DNA. Translation: EAW52399.1.
RefSeqiNP_000139.1. NM_000148.3.
NP_001316806.1. NM_001329877.1.
XP_016882042.1. XM_017026553.1.
UniGeneiHs.69747.

Genome annotation databases

GeneIDi2523.
KEGGihsa:2523.
UCSCiuc002pkk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY611628 Genomic DNA. Translation: AAT42242.1.
KF906450 Genomic DNA. Translation: AHJ09661.1.
FM180557 Genomic DNA. Translation: CAQ81977.1.
CH471177 Genomic DNA. Translation: EAW52399.1.
RefSeqiNP_000139.1. NM_000148.3.
NP_001316806.1. NM_001329877.1.
XP_016882042.1. XM_017026553.1.
UniGeneiHs.69747.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312021.

Protein family/group databases

CAZyiGT11. Glycosyltransferase Family 11.

Protocols and materials databases

DNASUi2523.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2523.
KEGGihsa:2523.
UCSCiuc002pkk.3. human.

Organism-specific databases

CTDi2523.
PharmGKBiPA28428.

Phylogenomic databases

eggNOGiENOG410IFKR. Eukaryota.
ENOG4111HG3. LUCA.
HOVERGENiHBG004338.
KOiK00718.
OMAiFLHIHQD.
OrthoDBiEOG091G0X2P.
PhylomeDBiQ6IZA2.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

GenomeRNAii2523.

Gene expression databases

BgeeiENSG00000174951.
ExpressionAtlasiQ6IZA2. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR002516. Glyco_trans_11.
PANTHERiPTHR11927. PTHR11927. 1 hit.
PfamiView protein in Pfam
PF01531. Glyco_transf_11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6IZA2_HUMAN
AccessioniPrimary (citable) accession number: Q6IZA2
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: February 15, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.