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Protein

2-oxoglutarate receptor 1

Gene

Oxgr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate receptor 1
Alternative name(s):
Alpha-ketoglutarate receptor 1
G-protein coupled receptor 99
Gene namesi
Name:Oxgr1
Synonyms:Gpr99
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2685145. Oxgr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 69CytoplasmicSequence analysis10
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 116ExtracellularSequence analysisAdd BLAST26
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 151CytoplasmicSequence analysisAdd BLAST14
Transmembranei152 – 172Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini173 – 200ExtracellularSequence analysisAdd BLAST28
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 242CytoplasmicSequence analysisAdd BLAST21
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 284ExtracellularSequence analysisAdd BLAST21
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 337CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699951 – 3372-oxoglutarate receptor 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6IYF8.
PeptideAtlasiQ6IYF8.
PRIDEiQ6IYF8.

Expressioni

Tissue specificityi

Predominanltly expressed in the kidney with limited expression in the testis and the smooth muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000044819.
CleanExiMM_OXGR1.
GenevisibleiQ6IYF8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055137.

Structurei

3D structure databases

ProteinModelPortaliQ6IYF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHYM. Eukaryota.
ENOG410YD7Q. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG106870.
InParanoidiQ6IYF8.
KOiK08419.
OMAiCKFIRFG.
OrthoDBiEOG091G0A94.
PhylomeDBiQ6IYF8.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IYF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEPLDSPAS DSDFLDYPSA LGNCTDEQIS FKMQYLPVIY SIIFLVGFPG
60 70 80 90 100
NTVAISIYIF KMRPWRGSTV IMLNLALTDL LYLTSLPFLI HYYASGENWI
110 120 130 140 150
FGDFMCKFIR FGFHFNLYSS ILFLTCFSLF RYVVIIHPMS CFSIQKTRWA
160 170 180 190 200
VVACAGVWVI SLVAVMPMTF LITSTTRTNR SACLDLTSSD DLTTIKWYNL
210 220 230 240 250
ILTATTFCLP LVIVTLCYTT IISTLTHGPR THSCFKQKAR RLTILLLLVF
260 270 280 290 300
YICFLPFHIL RVIRIESRLL SISCSIESHI HEAYIVSRPL AALNTFGNLL
310 320 330
LYVVVSNNFQ QAFCSIVRCK ASGDLEQGKK DSCSNNP
Length:337
Mass (Da):38,230
Last modified:July 5, 2004 - v1
Checksum:i079A603551112277
GO

Sequence cautioni

The sequence BAE25093 differs from that shown. Reason: Frameshift at position 325.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY612852 mRNA. Translation: AAT10591.1.
AK142510 mRNA. Translation: BAE25093.1. Frameshift.
BC119196 mRNA. Translation: AAI19197.1.
BC119200 mRNA. Translation: AAI19201.1.
CCDSiCCDS27340.1.
RefSeqiNP_001001490.1. NM_001001490.3.
UniGeneiMm.138520.

Genome annotation databases

EnsembliENSMUST00000058213; ENSMUSP00000055137; ENSMUSG00000044819.
GeneIDi239283.
KEGGimmu:239283.
UCSCiuc007uzo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY612852 mRNA. Translation: AAT10591.1.
AK142510 mRNA. Translation: BAE25093.1. Frameshift.
BC119196 mRNA. Translation: AAI19197.1.
BC119200 mRNA. Translation: AAI19201.1.
CCDSiCCDS27340.1.
RefSeqiNP_001001490.1. NM_001001490.3.
UniGeneiMm.138520.

3D structure databases

ProteinModelPortaliQ6IYF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055137.

Chemistry databases

GuidetoPHARMACOLOGYi162.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ6IYF8.
PeptideAtlasiQ6IYF8.
PRIDEiQ6IYF8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058213; ENSMUSP00000055137; ENSMUSG00000044819.
GeneIDi239283.
KEGGimmu:239283.
UCSCiuc007uzo.1. mouse.

Organism-specific databases

CTDi27199.
MGIiMGI:2685145. Oxgr1.

Phylogenomic databases

eggNOGiENOG410IHYM. Eukaryota.
ENOG410YD7Q. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG106870.
InParanoidiQ6IYF8.
KOiK08419.
OMAiCKFIRFG.
OrthoDBiEOG091G0A94.
PhylomeDBiQ6IYF8.
TreeFamiTF330775.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ6IYF8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044819.
CleanExiMM_OXGR1.
GenevisibleiQ6IYF8. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXGR1_MOUSE
AccessioniPrimary (citable) accession number: Q6IYF8
Secondary accession number(s): Q0VEK6, Q3UQE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.