Q6IYD9 (Q6IYD9_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein Wnt RuleBase RU003503

Gene names

Name:	wnt3a EMBL AAT38336.1 ZFIN ZDB-GENE-001106-1
Synonyms:	wnt3 l ZFIN ZDB-GENE-001106-1, wnt3l ZFIN ZDB-GENE-001106-1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAT38336.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors By similarity. RuleBase RU003500
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity RuleBase RU003500.
Sequence similarities	Belongs to the Wnt family. RuleBase RU003500

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS005817 RuleBase RU003500
Cellular component	Extracellular matrix SAAS SAAS005817 Secreted
Molecular function	Developmental protein SAAS SAAS005817 RuleBase RU003500
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway involved in forebrain neuroblast division Inferred from Biological aspect of Ancestor. Source: RefGenome Wnt receptor signaling pathway, calcium modulating pathway Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome axonogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome convergent extension Inferred from direct assay. Source: ZFIN determination of left/right symmetry Inferred from Biological aspect of Ancestor. Source: RefGenome dorsal/ventral neural tube patterning Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular matrix organization Inferred from Biological aspect of Ancestor. Source: RefGenome hemopoietic stem cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome hippocampus development Inferred from Biological aspect of Ancestor. Source: RefGenome inner ear morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome mammary gland development Inferred from Biological aspect of Ancestor. Source: RefGenome midbrain-hindbrain boundary development Inferred from genetic interaction Ref.1. Source: ZFIN negative regulation of fat cell differentiation Inferred from Biological aspect of Ancestor. Source: RefGenome notochord development Inferred from mutant phenotype. Source: ZFIN paraxial mesodermal cell fate commitment Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome somitogenesis Inferred from mutant phenotype. Source: ZFIN tail morphogenesis Inferred from mutant phenotype. Source: ZFIN
Cellular component	early endosome Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome late endosome Inferred from Biological aspect of Ancestor. Source: RefGenome membrane raft Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	frizzled-2 binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6IYD9 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: B2BD3741953359D6	FASTA	365	41,484
	10 20 30 40 50 60 MIYLGYFLFL FCGLTRVMAS YPIWWSLAVG HQYTSLGTQP IMCSSIPGLV PKQLRFCRNY 70 80 90 100 110 120 VEIMPSVAEG VKIGIQECQH QFRGRRWNCT TINDKLAIFG PVLDKEKERK IGFKQAKATR 130 140 150 160 170 180 ESAFVHAIAS AGVAFXVTRA CTEGSATICG CDSRRKGPPG EGWKWGGCSE DVEFGSMVSR 190 200 210 220 230 240 EFADARENRP DARSAMNRHN NEAGRSSITD HMYLKCKCHG LSGSCEVKTC WWSQPDFRVI 250 260 270 280 290 300 GDYMKDKYDS ASEMVVEKHR ESRGWVETLR PKYPYYKPPT ETDLVYYESS PNFCEPNPET 310 320 330 340 350 360 GSFGTRDRTC NLTSHGIDGC DLLCCGRGHN TRTEKRKEKC HCIFHWCCYV SCQECTRVYD VHTCK

References

[1]	"Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formation." Buckles G.R., Thorpe C.J., Ramel M.C., Lekven A.C. Mech. Dev. 121:437-447(2004) [PubMed: 15147762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY613787 mRNA. Translation: AAT38336.1.
IPI	IPI00510037.
RefSeq	NP_001007186.1. NM_001007185.1.
UniGene	Dr.92208.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6IYD9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	60632.
KEGG	dre:60632.
Organism-specific databases
CTD	89780.
ZFIN	ZDB-GENE-001106-1. wnt3a.
Phylogenomic databases
eggNOG	fiNOG04912.
GeneTree	ENSGT00600000084119.
HOVERGEN	HBG001595.
InParanoid	Q6IYD9.
Gene expression databases
Bgee	Q6IYD9.
Family and domain databases
InterPro	IPR005817. Wnt. IPR009141. Wnt3. IPR018161. Wnt_grthfactor_CS. [Graphical view]
KO	K00312.
PANTHER	PTHR12027. Wnt. 1 hit. PTHR12027:SF18. Wnt3. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01843. WNT3PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6IYD9_DANRE

Accession

Primary (citable) accession number: Q6IYD9

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)