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Protein

TNF receptor-associated factor 6

Gene

traf6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri71 – 11040RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri151 – 20353TRAF-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 26057TRAF-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: ZFIN
  • positive regulation of transcription, DNA-templated Source: ZFIN
  • protein K63-linked ubiquitination Source: UniProtKB
  • regulation of apoptotic process Source: InterPro
  • response to bacterium Source: ZFIN
  • response to virus Source: ZFIN
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-166058. MyD88:Mal cascade initiated on plasma membrane.
R-DRE-168638. NOD1/2 Signaling Pathway.
R-DRE-193692. Regulated proteolysis of p75NTR.
R-DRE-202424. Downstream TCR signaling.
R-DRE-209543. p75NTR recruits signalling complexes.
R-DRE-209560. NF-kB is activated and signals survival.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DRE-446652. Interleukin-1 signaling.
R-DRE-450302. activated TAK1 mediates p38 MAPK activation.
R-DRE-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-937039. IRAK1 recruits IKK complex.
R-DRE-937042. IRAK2 mediated activation of TAK1 complex.
R-DRE-937072. TRAF6 mediated induction of TAK1 complex.
R-DRE-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-DRE-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-DRE-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
R-DRE-975155. MyD88 dependent cascade initiated on endosome.
R-DRE-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-DRE-975871. MyD88 cascade initiated on plasma membrane.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
TNF receptor-associated factor 6 (EC:6.3.2.-)
Alternative name(s):
E3 ubiquitin-protein ligase TRAF6
Gene namesi
Name:traf6
ORF Names:si:dkey-56p7.3, zgc:63704
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-030131-5735. traf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542TNF receptor-associated factor 6PRO_0000391612Add
BLAST

Proteomic databases

PaxDbiQ6IWL4.

Expressioni

Gene expression databases

BgeeiQ6IWL4.

Interactioni

Subunit structurei

Homooligomer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000036715.

Structurei

3D structure databases

ProteinModelPortaliQ6IWL4.
SMRiQ6IWL4. Positions 45-129, 371-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini374 – 520147MATHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni489 – 4968Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili311 – 37363Sequence analysisAdd
BLAST

Domaini

The coiled coil domain mediates homo- and hetero-oligomerization.By similarity
The MATH/TRAF domain binds to receptor cytoplasmic domains.By similarity

Sequence similaritiesi

Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 2 TRAF-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri71 – 11040RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri151 – 20353TRAF-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 26057TRAF-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ISDW. Eukaryota.
ENOG410XTXK. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000006625.
HOVERGENiHBG060248.
InParanoidiQ6IWL4.
KOiK03175.
OMAiCEMELIR.
OrthoDBiEOG7966G5.
PhylomeDBiQ6IWL4.
TreeFamiTF321154.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027139. TRAF6.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF85. PTHR10131:SF85. 1 hit.
PfamiPF02176. zf-TRAF. 2 hits.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IWL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACNDVDKSS FDDVCCDSGH SSCAAAMEKE RESFLSPTEN PSTISVSSSM
60 70 80 90 100
PPDQQGYDVE FDPPLESKYE CPICLMGLRS AVQTPCGHRF CDSCIRKSIR
110 120 130 140 150
DTGQKCPVDN EVLLEEQLFP DNFAKREILS LTVKCSNFGC SEKMELRQLE
160 170 180 190 200
KHLSQCRFAT APCPQCQESV PISHLDEHKS QHCLQRIMTC PDCAGSFVYA
210 220 230 240 250
VKQNHEQFCP FANTVCEYCE MELIRDQLAL HCDTDCLKAP VACTFSTFGC
260 270 280 290 300
REKMTRNELA QHMQEFTQMH MRYMAEFLRS QTLNNCTMPS AAAHLSSDDR
310 320 330 340 350
GASARSPDSC QCKQELLNLR ETVLELEGRL VRQDQQIREL CIHNDTQKNQ
360 370 380 390 400
VTELRRKLVS LEESTRELEA QQYQGIYVWR VENFSHHLRN QEAGQPIVLH
410 420 430 440 450
SPPFYTGRPG YKLCLRLHLQ TPSAPRCSNF ISLFVHTMQG EFDSQLSWPL
460 470 480 490 500
QGTIRLAVLD QVEGQHHIEV METKPDLQAF QRPTVMRNPK GFGYVTFLHL
510 520 530 540
QALRQRGFVK EDVLLVRCEV TPRFDASLRR EGVQPRGPEP SI
Length:542
Mass (Da):61,806
Last modified:February 9, 2010 - v2
Checksum:i23CA0DAFA380B133
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131D → G in AAT37634 (Ref. 1) Curated
Sequence conflicti52 – 521P → T in AAT37634 (Ref. 1) Curated
Sequence conflicti52 – 521P → T in AAH55214 (Ref. 3) Curated
Sequence conflicti84 – 841T → A in AAH55214 (Ref. 3) Curated
Sequence conflicti172 – 1721I → M in AAT37634 (Ref. 1) Curated
Sequence conflicti204 – 2041N → S in AAT37634 (Ref. 1) Curated
Sequence conflicti295 – 2951L → S in AAT37634 (Ref. 1) Curated
Sequence conflicti295 – 2951L → S in AAH55214 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616583 mRNA. Translation: AAT37634.1.
AL929208 Genomic DNA. Translation: CAK11108.1.
BC055214 mRNA. Translation: AAH55214.1.
BC171483 mRNA. Translation: AAI71483.1.
BC171487 mRNA. Translation: AAI71487.1.
RefSeqiNP_001038217.1. NM_001044752.1.
UniGeneiDr.74618.

Genome annotation databases

EnsembliENSDART00000038273; ENSDARP00000036715; ENSDARG00000028058.
GeneIDi554561.
KEGGidre:554561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616583 mRNA. Translation: AAT37634.1.
AL929208 Genomic DNA. Translation: CAK11108.1.
BC055214 mRNA. Translation: AAH55214.1.
BC171483 mRNA. Translation: AAI71483.1.
BC171487 mRNA. Translation: AAI71487.1.
RefSeqiNP_001038217.1. NM_001044752.1.
UniGeneiDr.74618.

3D structure databases

ProteinModelPortaliQ6IWL4.
SMRiQ6IWL4. Positions 45-129, 371-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000036715.

Proteomic databases

PaxDbiQ6IWL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000038273; ENSDARP00000036715; ENSDARG00000028058.
GeneIDi554561.
KEGGidre:554561.

Organism-specific databases

CTDi7189.
ZFINiZDB-GENE-030131-5735. traf6.

Phylogenomic databases

eggNOGiENOG410ISDW. Eukaryota.
ENOG410XTXK. LUCA.
GeneTreeiENSGT00550000074359.
HOGENOMiHOG000006625.
HOVERGENiHBG060248.
InParanoidiQ6IWL4.
KOiK03175.
OMAiCEMELIR.
OrthoDBiEOG7966G5.
PhylomeDBiQ6IWL4.
TreeFamiTF321154.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-DRE-166058. MyD88:Mal cascade initiated on plasma membrane.
R-DRE-168638. NOD1/2 Signaling Pathway.
R-DRE-193692. Regulated proteolysis of p75NTR.
R-DRE-202424. Downstream TCR signaling.
R-DRE-209543. p75NTR recruits signalling complexes.
R-DRE-209560. NF-kB is activated and signals survival.
R-DRE-2871837. FCERI mediated NF-kB activation.
R-DRE-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-DRE-446652. Interleukin-1 signaling.
R-DRE-450302. activated TAK1 mediates p38 MAPK activation.
R-DRE-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-DRE-5607764. CLEC7A (Dectin-1) signaling.
R-DRE-937039. IRAK1 recruits IKK complex.
R-DRE-937042. IRAK2 mediated activation of TAK1 complex.
R-DRE-937072. TRAF6 mediated induction of TAK1 complex.
R-DRE-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-DRE-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-DRE-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
R-DRE-975155. MyD88 dependent cascade initiated on endosome.
R-DRE-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-DRE-975871. MyD88 cascade initiated on plasma membrane.

Miscellaneous databases

NextBioi20880774.
PROiQ6IWL4.

Gene expression databases

BgeeiQ6IWL4.

Family and domain databases

Gene3Di2.60.210.10. 1 hit.
3.30.40.10. 1 hit.
3.90.890.10. 1 hit.
InterProiIPR002083. MATH/TRAF_dom.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027139. TRAF6.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERiPTHR10131:SF85. PTHR10131:SF85. 1 hit.
PfamiPF02176. zf-TRAF. 2 hits.
[Graphical view]
PIRSFiPIRSF015614. TRAF. 1 hit.
SMARTiSM00061. MATH. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 3 hits.
PROSITEiPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Phelan P.E. III, Mellon M.T., Kim C.H.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiTRAF6_DANRE
AccessioniPrimary (citable) accession number: Q6IWL4
Secondary accession number(s): Q1MTB3, Q7SXX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 11, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.