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Protein

TNF receptor-associated factor 6

Gene

traf6

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri71 – 110RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri151 – 203TRAF-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri204 – 260TRAF-type 2PROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: ZFIN
  • positive regulation of transcription, DNA-templated Source: ZFIN
  • protein K63-linked ubiquitination Source: UniProtKB
  • regulation of apoptotic process Source: InterPro
  • regulation of I-kappaB kinase/NF-kappaB signaling Source: InterPro
  • response to bacterium Source: ZFIN
  • response to virus Source: ZFIN
  • signal transduction Source: InterPro

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-166058 MyD88:Mal cascade initiated on plasma membrane
R-DRE-168638 NOD1/2 Signaling Pathway
R-DRE-193692 Regulated proteolysis of p75NTR
R-DRE-202424 Downstream TCR signaling
R-DRE-209543 p75NTR recruits signalling complexes
R-DRE-209560 NF-kB is activated and signals survival
R-DRE-2871837 FCERI mediated NF-kB activation
R-DRE-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-DRE-450302 activated TAK1 mediates p38 MAPK activation
R-DRE-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-DRE-5607764 CLEC7A (Dectin-1) signaling
R-DRE-5689880 Ub-specific processing proteases
R-DRE-5689896 Ovarian tumor domain proteases
R-DRE-9020702 Interleukin-1 signaling
R-DRE-937039 IRAK1 recruits IKK complex
R-DRE-937042 IRAK2 mediated activation of TAK1 complex
R-DRE-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex
R-DRE-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-DRE-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-DRE-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-DRE-975155 MyD88 dependent cascade initiated on endosome
R-DRE-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
R-DRE-975871 MyD88 cascade initiated on plasma membrane
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
TNF receptor-associated factor 6 (EC:2.3.2.27)
Alternative name(s):
E3 ubiquitin-protein ligase TRAF6
RING-type E3 ubiquitin transferase TRAF6Curated
Gene namesi
Name:traf6
ORF Names:si:dkey-56p7.3, zgc:63704
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-030131-5735 traf6

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003916121 – 542TNF receptor-associated factor 6Add BLAST542

Proteomic databases

PaxDbiQ6IWL4

Expressioni

Gene expression databases

BgeeiENSDARG00000028058

Interactioni

Subunit structurei

Homooligomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000036715

Structurei

3D structure databases

ProteinModelPortaliQ6IWL4
SMRiQ6IWL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini374 – 520MATHPROSITE-ProRule annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni489 – 496Substrate bindingBy similarity8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili311 – 373Sequence analysisAdd BLAST63

Domaini

The coiled coil domain mediates homo- and hetero-oligomerization.By similarity
The MATH/TRAF domain binds to receptor cytoplasmic domains.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri71 – 110RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40
Zinc fingeri151 – 203TRAF-type 1PROSITE-ProRule annotationAdd BLAST53
Zinc fingeri204 – 260TRAF-type 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410ISDW Eukaryota
ENOG410XTXK LUCA
GeneTreeiENSGT00550000074359
HOGENOMiHOG000006625
HOVERGENiHBG060248
InParanoidiQ6IWL4
KOiK03175
OMAiPGYKLCL
OrthoDBiEOG091G0GHD
PhylomeDBiQ6IWL4
TreeFamiTF321154

Family and domain databases

CDDicd03776 MATH_TRAF6, 1 hit
Gene3Di2.60.210.101 hit
3.30.40.103 hits
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR012227 TNF_rcpt--assoc_TRAF
IPR008974 TRAF-like
IPR027139 TRAF6
IPR037309 TRAF6_MATH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
IPR001293 Znf_TRAF
PANTHERiPTHR10131:SF111 PTHR10131:SF111, 1 hit
PfamiView protein in Pfam
PF02176 zf-TRAF, 2 hits
PIRSFiPIRSF015614 TRAF, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49599 SSF49599, 3 hits
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
PS50145 ZF_TRAF, 1 hit

Sequencei

Sequence statusi: Complete.

Q6IWL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACNDVDKSS FDDVCCDSGH SSCAAAMEKE RESFLSPTEN PSTISVSSSM
60 70 80 90 100
PPDQQGYDVE FDPPLESKYE CPICLMGLRS AVQTPCGHRF CDSCIRKSIR
110 120 130 140 150
DTGQKCPVDN EVLLEEQLFP DNFAKREILS LTVKCSNFGC SEKMELRQLE
160 170 180 190 200
KHLSQCRFAT APCPQCQESV PISHLDEHKS QHCLQRIMTC PDCAGSFVYA
210 220 230 240 250
VKQNHEQFCP FANTVCEYCE MELIRDQLAL HCDTDCLKAP VACTFSTFGC
260 270 280 290 300
REKMTRNELA QHMQEFTQMH MRYMAEFLRS QTLNNCTMPS AAAHLSSDDR
310 320 330 340 350
GASARSPDSC QCKQELLNLR ETVLELEGRL VRQDQQIREL CIHNDTQKNQ
360 370 380 390 400
VTELRRKLVS LEESTRELEA QQYQGIYVWR VENFSHHLRN QEAGQPIVLH
410 420 430 440 450
SPPFYTGRPG YKLCLRLHLQ TPSAPRCSNF ISLFVHTMQG EFDSQLSWPL
460 470 480 490 500
QGTIRLAVLD QVEGQHHIEV METKPDLQAF QRPTVMRNPK GFGYVTFLHL
510 520 530 540
QALRQRGFVK EDVLLVRCEV TPRFDASLRR EGVQPRGPEP SI
Length:542
Mass (Da):61,806
Last modified:February 9, 2010 - v2
Checksum:i23CA0DAFA380B133
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13D → G in AAT37634 (Ref. 1) Curated1
Sequence conflicti52P → T in AAT37634 (Ref. 1) Curated1
Sequence conflicti52P → T in AAH55214 (Ref. 3) Curated1
Sequence conflicti84T → A in AAH55214 (Ref. 3) Curated1
Sequence conflicti172I → M in AAT37634 (Ref. 1) Curated1
Sequence conflicti204N → S in AAT37634 (Ref. 1) Curated1
Sequence conflicti295L → S in AAT37634 (Ref. 1) Curated1
Sequence conflicti295L → S in AAH55214 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616583 mRNA Translation: AAT37634.1
AL929208 Genomic DNA Translation: CAK11108.1
BC055214 mRNA Translation: AAH55214.1
BC171483 mRNA Translation: AAI71483.1
BC171487 mRNA Translation: AAI71487.1
RefSeqiNP_001038217.1, NM_001044752.1
UniGeneiDr.74618

Genome annotation databases

EnsembliENSDART00000038273; ENSDARP00000036715; ENSDARG00000028058
GeneIDi554561
KEGGidre:554561

Similar proteinsi

Entry informationi

Entry nameiTRAF6_DANRE
AccessioniPrimary (citable) accession number: Q6IWL4
Secondary accession number(s): Q1MTB3, Q7SXX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: February 9, 2010
Last modified: February 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome