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Protein

Anoctamin-7

Gene

ANO7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-7
Alternative name(s):
Dresden transmembrane protein of the prostate
Short name:
D-TMPP
IPCA-5
New gene expressed in prostate
Prostate cancer-associated protein 5
Transmembrane protein 16G
Gene namesi
Name:ANO7
Synonyms:NGEP, PCANAP5, TMEM16G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:31677. ANO7.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 355CytoplasmicSequence analysisAdd BLAST355
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21
Topological domaini377 – 420ExtracellularSequence analysisAdd BLAST44
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Topological domaini442 – 499CytoplasmicSequence analysisAdd BLAST58
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 550ExtracellularSequence analysisAdd BLAST30
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 588CytoplasmicSequence analysisAdd BLAST17
Transmembranei589 – 609HelicalSequence analysisAdd BLAST21
Topological domaini610 – 714ExtracellularSequence analysisAdd BLAST105
Transmembranei715 – 735HelicalSequence analysisAdd BLAST21
Topological domaini736 – 763CytoplasmicSequence analysisAdd BLAST28
Transmembranei764 – 784HelicalSequence analysisAdd BLAST21
Topological domaini785 – 843ExtracellularSequence analysisAdd BLAST59
Transmembranei844 – 864HelicalSequence analysisAdd BLAST21
Topological domaini865 – 933CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

  • cell junction Source: UniProtKB-SubCell
  • cytosol Source: UniProtKB-SubCell
  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: UniProtKB
  • nucleus Source: Ensembl
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50636.
OpenTargetsiENSG00000146205.
PharmGKBiPA32980.

Polymorphism and mutation databases

BioMutaiANO7.
DMDMi334302764.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002893261 – 933Anoctamin-7Add BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi809N-linked (GlcNAc...)1 Publication1
Glycosylationi824N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6IWH7.
PeptideAtlasiQ6IWH7.
PRIDEiQ6IWH7.

PTM databases

iPTMnetiQ6IWH7.
PhosphoSitePlusiQ6IWH7.

Expressioni

Tissue specificityi

Specifically expressed in epithelial cells of the prostate (at protein level).3 Publications

Inductioni

Up-regulated by androgen.1 Publication

Gene expression databases

BgeeiENSG00000146205.
CleanExiHS_ANO7.
ExpressionAtlasiQ6IWH7. baseline and differential.
GenevisibleiQ6IWH7. HS.

Organism-specific databases

HPAiHPA035730.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000274979.

Structurei

3D structure databases

ProteinModelPortaliQ6IWH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2514. Eukaryota.
ENOG410XS4S. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ6IWH7.
KOiK19501.
OMAiPLCLDCP.
OrthoDBiEOG091G01JF.
PhylomeDBiQ6IWH7.
TreeFamiTF314265.

Family and domain databases

InterProiIPR032394. Anoct_dimer.
IPR007632. Anoctamin.
IPR031296. Anoctamin-7.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF22. PTHR12308:SF22. 1 hit.
PfamiPF16178. Anoct_dimer. 1 hit.
PF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6IWH7-1) [UniParc]FASTAAdd to basket
Also known as: NGEP-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRMAATAWAG LQGPPLPTLC PAVRTGLYCR DQAHAERWAM TSETSSGSHC
60 70 80 90 100
ARSRMLRRRA QEEDSTVLID VSPPEAEKRG SYGSTAHASE PGGQQAAACR
110 120 130 140 150
AGSPAKPRIA DFVLVWEEDL KLDRQQDSAA RDRTDMHRTW RETFLDNLRA
160 170 180 190 200
AGLCVDQQDV QDGNTTVHYA LLSASWAVLC YYAEDLRLKL PLQELPNQAS
210 220 230 240 250
NWSAGLLAWL GIPNVLLEVV PDVPPEYYSC RFRVNKLPRF LGSDNQDTFF
260 270 280 290 300
TSTKRHQILF EILAKTPYGH EKKNLLGIHQ LLAEGVLSAA FPLHDGPFKT
310 320 330 340 350
PPEGPQAPRL NQRQVLFQHW ARWGKWNKYQ PLDHVRRYFG EKVALYFAWL
360 370 380 390 400
GFYTGWLLPA AVVGTLVFLV GCFLVFSDIP TQELCGSKDS FEMCPLCLDC
410 420 430 440 450
PFWLLSSACA LAQAGRLFDH GGTVFFSLFM ALWAVLLLEY WKRKSATLAY
460 470 480 490 500
RWDCSDYEDT EERPRPQFAA SAPMTAPNPI TGEDEPYFPE RSRARRMLAG
510 520 530 540 550
SVVIVVMVAV VVMCLVSIIL YRAIMAIVVS RSGNTLLAAW ASRIASLTGS
560 570 580 590 600
VVNLVFILIL SKIYVSLAHV LTRWEMHRTQ TKFEDAFTLK VFIFQFVNFY
610 620 630 640 650
SSPVYIAFFK GRFVGYPGNY HTLFGVRNEE CAAGGCLIEL AQELLVIMVG
660 670 680 690 700
KQVINNMQEV LIPKLKGWWQ KFRLRSKKRK AGASAGASQG PWEDDYELVP
710 720 730 740 750
CEGLFDEYLE MVLQFGFVTI FVAACPLAPL FALLNNWVEI RLDARKFVCE
760 770 780 790 800
YRRPVAERAQ DIGIWFHILA GLTHLAVISN AFLLAFSSDF LPRAYYRWTR
810 820 830 840 850
AHDLRGFLNF TLARAPSSFA AAHNRTCRYR AFRDDDGHYS QTYWNLLAIR
860 870 880 890 900
LAFVIVFEHV VFSVGRLLDL LVPDIPESVE IKVKREYYLA KQALAENEVL
910 920 930
FGTNGTKDEQ PEGSELSSHW TPFTVPKASQ LQQ
Length:933
Mass (Da):105,532
Last modified:May 31, 2011 - v2
Checksum:iD6FD42578A4BD773
GO
Isoform 2 (identifier: Q6IWH7-2) [UniParc]FASTAAdd to basket
Also known as: NGEP-S

The sequence of this isoform differs from the canonical sequence as follows:
     110-110: Missing.
     158-180: QDVQDGNTTVHYALLSASWAVLC → VRGGCHGQGPRPCIHSVTHDLAA
     181-933: Missing.

Show »
Length:179
Mass (Da):19,590
Checksum:iA300C8733A94485B
GO
Isoform 3 (identifier: Q6IWH7-3) [UniParc]FASTAAdd to basket
Also known as: D-TMPP

The sequence of this isoform differs from the canonical sequence as follows:
     110-110: Missing.
     859-859: H → VAEAPAGSPIHGMRPRPCALPNSSTW
     860-933: Missing.

Show »
Length:883
Mass (Da):99,754
Checksum:iA91DCD1079F7AB64
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03261667V → I.Corresponds to variant rs2302054dbSNPEnsembl.1
Natural variantiVAR_065166912E → K.1 PublicationCorresponds to variant rs7590653dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026004110Missing in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_026005158 – 180QDVQD…WAVLC → VRGGCHGQGPRPCIHSVTHD LAA in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_026006181 – 933Missing in isoform 2. 1 PublicationAdd BLAST753
Alternative sequenceiVSP_026007859H → VAEAPAGSPIHGMRPRPCAL PNSSTW in isoform 3. Curated1
Alternative sequenceiVSP_026008860 – 933Missing in isoform 3. CuratedAdd BLAST74

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY617079 mRNA. Translation: AAT40139.1.
AY617080 mRNA. Translation: AAT40140.1.
AC005237 Genomic DNA. No translation available.
AC104841 Genomic DNA. No translation available.
AC111201 Genomic DNA. No translation available.
CCDSiCCDS33423.1. [Q6IWH7-1]
CCDS46563.1. [Q6IWH7-2]
RefSeqiNP_001001666.1. NM_001001666.3. [Q6IWH7-2]
NP_001001891.2. NM_001001891.3. [Q6IWH7-1]
UniGeneiHs.163909.

Genome annotation databases

EnsembliENST00000274979; ENSP00000274979; ENSG00000146205. [Q6IWH7-1]
ENST00000402430; ENSP00000385418; ENSG00000146205. [Q6IWH7-3]
ENST00000402530; ENSP00000383985; ENSG00000146205. [Q6IWH7-2]
GeneIDi50636.
KEGGihsa:50636.
UCSCiuc002waw.4. human. [Q6IWH7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY617079 mRNA. Translation: AAT40139.1.
AY617080 mRNA. Translation: AAT40140.1.
AC005237 Genomic DNA. No translation available.
AC104841 Genomic DNA. No translation available.
AC111201 Genomic DNA. No translation available.
CCDSiCCDS33423.1. [Q6IWH7-1]
CCDS46563.1. [Q6IWH7-2]
RefSeqiNP_001001666.1. NM_001001666.3. [Q6IWH7-2]
NP_001001891.2. NM_001001891.3. [Q6IWH7-1]
UniGeneiHs.163909.

3D structure databases

ProteinModelPortaliQ6IWH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000274979.

PTM databases

iPTMnetiQ6IWH7.
PhosphoSitePlusiQ6IWH7.

Polymorphism and mutation databases

BioMutaiANO7.
DMDMi334302764.

Proteomic databases

PaxDbiQ6IWH7.
PeptideAtlasiQ6IWH7.
PRIDEiQ6IWH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274979; ENSP00000274979; ENSG00000146205. [Q6IWH7-1]
ENST00000402430; ENSP00000385418; ENSG00000146205. [Q6IWH7-3]
ENST00000402530; ENSP00000383985; ENSG00000146205. [Q6IWH7-2]
GeneIDi50636.
KEGGihsa:50636.
UCSCiuc002waw.4. human. [Q6IWH7-1]

Organism-specific databases

CTDi50636.
DisGeNETi50636.
GeneCardsiANO7.
HGNCiHGNC:31677. ANO7.
HPAiHPA035730.
MIMi605096. gene.
neXtProtiNX_Q6IWH7.
OpenTargetsiENSG00000146205.
PharmGKBiPA32980.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2514. Eukaryota.
ENOG410XS4S. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ6IWH7.
KOiK19501.
OMAiPLCLDCP.
OrthoDBiEOG091G01JF.
PhylomeDBiQ6IWH7.
TreeFamiTF314265.

Enzyme and pathway databases

ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Miscellaneous databases

GenomeRNAii50636.
PROiQ6IWH7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146205.
CleanExiHS_ANO7.
ExpressionAtlasiQ6IWH7. baseline and differential.
GenevisibleiQ6IWH7. HS.

Family and domain databases

InterProiIPR032394. Anoct_dimer.
IPR007632. Anoctamin.
IPR031296. Anoctamin-7.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF22. PTHR12308:SF22. 1 hit.
PfamiPF16178. Anoct_dimer. 1 hit.
PF04547. Anoctamin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANO7_HUMAN
AccessioniPrimary (citable) accession number: Q6IWH7
Secondary accession number(s): Q6IWH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 31, 2011
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Caution

It is uncertain whether Met-1 or Met-55 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.