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Protein

Zinc finger protein 425

Gene

ZNF425

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 21223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri582 – 60423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri610 – 63223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri638 – 66023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri666 – 68823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 425
Gene namesi
Name:ZNF425
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:20690. ZNF425.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984453.

Polymorphism and mutation databases

BioMutaiZNF425.
DMDMi74762333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 752752Zinc finger protein 425PRO_0000234577Add
BLAST

Proteomic databases

PaxDbiQ6IV72.
PRIDEiQ6IV72.

PTM databases

iPTMnetiQ6IV72.
PhosphoSiteiQ6IV72.

Expressioni

Developmental stagei

Expressed in 30 days old embryos. Almost undetectable in 60 days old embryos and in adults.1 Publication

Gene expression databases

BgeeiQ6IV72.
ExpressionAtlasiQ6IV72. baseline and differential.
GenevisibleiQ6IV72. HS.

Organism-specific databases

HPAiHPA020087.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10250516,EBI-10172290

Protein-protein interaction databases

BioGridi127572. 1 interaction.
IntActiQ6IV72. 1 interaction.
STRINGi9606.ENSP00000367300.

Structurei

3D structure databases

ProteinModelPortaliQ6IV72.
SMRiQ6IV72. Positions 5-50, 166-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8072KRABPROSITE-ProRule annotationAdd
BLAST

Domaini

The C2H2 domain is necessary for the transcriptional repression.

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri190 – 21223C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri582 – 60423C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri610 – 63223C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri638 – 66023C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri666 – 68823C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri694 – 71623C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri722 – 74423C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111009.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6IV72.
KOiK09228.
OMAiKSFTQQY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6IV72.
TreeFamiTF326846.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IV72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPASVTVT FDDVALYFSE QEWEILEKWQ KQMYKQEMKT NYETLDSLGY
60 70 80 90 100
AFSKPDLITW MEQGRMLLIS EQGCLDKTRR TTSPPTDEQL NMKNTGKLLC
110 120 130 140 150
FDDEGTPRTK EEDCRLNGPQ KQDLCAALRG KERKILLAQT ATFQSPSLRE
160 170 180 190 200
TEILNKKVSI TAYDPDKKDL RHKPRETPGR LEIPTGPRCY SCYVCRKVFQ
210 220 230 240 250
VRRDLLKHKR SHSKSQLCRY PKYKNSSRGK SELRRTQRLL CQKKRFQCSE
260 270 280 290 300
CEKSYFLKGS LVTHQVVHTG QRPYPCPECD KTFRYRANLK KHLCLHRGER
310 320 330 340 350
PFCCGECGRA FVQQCELTEH LRLHSGEKPF QCPQCDRCFR LKRGMKVHLT
360 370 380 390 400
QHSGKRPFHC PECGRSFSRK AALKTHQRTH SEEKPFSCGE CGRKFIYKIK
410 420 430 440 450
LDEHIRVHTG EKPFSCPECN KSFRLKRSLK AHGLQHIGKR PFQCPECSRG
460 470 480 490 500
FFWRNAMRAH QRLHSEQKPF PCAECGKRFT RPSKLACHTR VHDRQKEFPC
510 520 530 540 550
GECKKTFSQQ SRLTQHLKVH TTEKPFSCAE CGRSFRRRAH LTEHTRLHSG
560 570 580 590 600
EEPFQCPECD KSFSWKASMK FHQRMHRDEK PFACGECDKT YTHQSQLTEH
610 620 630 640 650
LRLHSGEKPY QCPECEKTFR LKGNLKSHLL QHSGQKPFSC VMCGKSFTQQ
660 670 680 690 700
YRLTEHIRVH SGEKPFQCPE CDKSYCIRGS LKVHLYKHSG ERPFQCPECG
710 720 730 740 750
KGFLQKRSLK AHLCLHSGER PFSCDECGRS FTYVGALKTH IAVHAKEKPS

SL
Length:752
Mass (Da):87,721
Last modified:July 5, 2004 - v1
Checksum:iEDAADCD608517131
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891L → P in AAI25190 (PubMed:15489334).Curated
Sequence conflicti350 – 3501T → A in BAG51733 (PubMed:14702039).Curated
Sequence conflicti662 – 6621G → V in BAG51733 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti166 – 1661D → V.
Corresponds to variant rs6965052 [ dbSNP | Ensembl ].
VAR_033565

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621067 mRNA. Translation: AAT40438.1.
AK056498 mRNA. Translation: BAG51733.1.
AC073422 Genomic DNA. No translation available.
BC125189 mRNA. Translation: AAI25190.1.
CCDSiCCDS34773.1.
RefSeqiNP_001001661.1. NM_001001661.2.
UniGeneiHs.31743.

Genome annotation databases

EnsembliENST00000378061; ENSP00000367300; ENSG00000204947.
GeneIDi155054.
KEGGihsa:155054.
UCSCiuc003wfj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621067 mRNA. Translation: AAT40438.1.
AK056498 mRNA. Translation: BAG51733.1.
AC073422 Genomic DNA. No translation available.
BC125189 mRNA. Translation: AAI25190.1.
CCDSiCCDS34773.1.
RefSeqiNP_001001661.1. NM_001001661.2.
UniGeneiHs.31743.

3D structure databases

ProteinModelPortaliQ6IV72.
SMRiQ6IV72. Positions 5-50, 166-750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127572. 1 interaction.
IntActiQ6IV72. 1 interaction.
STRINGi9606.ENSP00000367300.

PTM databases

iPTMnetiQ6IV72.
PhosphoSiteiQ6IV72.

Polymorphism and mutation databases

BioMutaiZNF425.
DMDMi74762333.

Proteomic databases

PaxDbiQ6IV72.
PRIDEiQ6IV72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378061; ENSP00000367300; ENSG00000204947.
GeneIDi155054.
KEGGihsa:155054.
UCSCiuc003wfj.4. human.

Organism-specific databases

CTDi155054.
GeneCardsiZNF425.
HGNCiHGNC:20690. ZNF425.
HPAiHPA020087.
neXtProtiNX_Q6IV72.
PharmGKBiPA134984453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111009.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6IV72.
KOiK09228.
OMAiKSFTQQY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6IV72.
TreeFamiTF326846.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii155054.
PROiQ6IV72.

Gene expression databases

BgeeiQ6IV72.
ExpressionAtlasiQ6IV72. baseline and differential.
GenevisibleiQ6IV72. HS.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 19 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway."
    Wang Y., Ye X., Zhou J., Wan Y., Xie H., Deng Y., Yan Y., Li Y., Fan X., Yuan W., Mo X., Wu X.
    BMB Rep. 44:58-63(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Tissue: Heart.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZN425_HUMAN
AccessioniPrimary (citable) accession number: Q6IV72
Secondary accession number(s): B3KPM1, Q08AG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.