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Protein

Fanconi anemia group D2 protein homolog

Gene

Fancd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group D2 protein homolog
Short name:
Protein FACD2
Gene namesi
Name:Fancd2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303172. Fancd2.

Subcellular locationi

  • Nucleus By similarity

  • Note: Concentrates in nuclear foci during S phase and upon genotoxic stress.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14511451Fanconi anemia group D2 protein homologPRO_0000087170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei222 – 2221PhosphoserineBy similarity
Cross-linki561 – 561Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei716 – 7161PhosphoserineBy similarity
Modified residuei1257 – 12571PhosphoserineBy similarity
Modified residuei1406 – 14061PhosphoserineBy similarity
Modified residuei1414 – 14141PhosphoserineBy similarity

Post-translational modificationi

Monoubiquitinated on Lys-561 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W. Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1, and is mediated by FANCL/PHF9. Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression (By similarity).By similarity
Phosphorylated on several sites including Ser-222 and Ser-1401 in response to genotoxic stress.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6IV68.
PRIDEiQ6IV68.

PTM databases

PhosphoSiteiQ6IV68.

Expressioni

Gene expression databases

BgeeiENSRNOG00000024475.

Interactioni

Subunit structurei

Interacts directly with FANCE and FANCI. Interacts with USP1 and MEN1. The ubiquitinated form specifically interacts with BRCA1 and BLM. Both the nonubiquitinated and the monoubiquitinated forms interact with BRCA2; this interaction is mediated by phosphorylated FANCG and the complex also includes XCCR3 (By similarity). The ubiquitinated form specifically interacts with MTMR15/FAN1 (via UBZ-type zinc finger), leading to recruit MTMR15/FAN1 to sites of DNA damage. Interacts with DCLRE1B/Apollo (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033638.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 291291Interaction with FANCEBy similarityAdd
BLAST
Regioni248 – 359112Interaction with BRCA2By similarityAdd
BLAST

Phylogenomic databases

eggNOGiKOG4712. Eukaryota.
ENOG410XT6B. LUCA.
HOGENOMiHOG000060189.
HOVERGENiHBG060904.
InParanoidiQ6IV68.
KOiK10891.
PhylomeDBiQ6IV68.
TreeFamiTF101106.

Family and domain databases

InterProiIPR029448. FANCD2.
[Graphical view]
PfamiPF14631. FancD2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IV68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSKRSRLDF EDKETLAEDA SKIMKQPLSK LAKKSCGSHE VEENGSVFVR
60 70 80 90 100
LLKASGLTLK TGDNQNQLGV DQIIFQRKLF QALRKHPSYP KVIEEFVNGL
110 120 130 140 150
ESYTEDIDSL RNCLLSCERL QDEEASMGTF YSKSLIKLLL GIDILQPAII
160 170 180 190 200
KMLFEKVPQF LFESESRDGI SMPRLIISQL KWLDRIVDSK DLTTQMMQLI
210 220 230 240 250
SVAPVNLQHD FITSLPEILG DSQHANVGKE LSELLVQNTS LTVPILDVFS
260 270 280 290 300
SLRLDPNFLS EIRQLVMGKL SSVRLEDLPV IVKFILHSVT DSTSLEVIAE
310 320 330 340 350
LREKLNVQHF TLPSRIQASQ SKLKSKGLAS SSGNQENSDK DCIVLLFDVI
360 370 380 390 400
KSAIRYEKTI SEAWIKAIER IQSAAEHKAL DVAMLLIIYG TSTQTKKGVE
410 420 430 440 450
RLLRNKIQSD CIQEQLLDST FSTHCLVLKD ICPSILLLAQ TLFHSQDQRI
460 470 480 490 500
ILFGSLLCKY AFKFFDTYCQ QEVVGALVTH VCSGNEAEVD AALDVLLELI
510 520 530 540 550
VLNASAMRLN AAFIKGILDY LENMSPQQIR KIFCILSTLA FSQQPGTSNH
560 570 580 590 600
IQDDMHLVIR KQLSSTVFKY KLIGIIGAVT MAGIMAEDRT MPSNSTQRSA
610 620 630 640 650
SVSSEQHTQV TSLLQLVHSC TEHSPWASSL YYDEFANLIQ ERKLAPKTLE
660 670 680 690 700
WVAQTIFNDF QDAFVVDFCA VPEGDFPFPV KALYGLEECN TQDGIVINLL
710 720 730 740 750
PLFFQEFAKD VSQVTSQESS QKSMSPLCLA SHFRLLRLCV ARQHNGNLDE
760 770 780 790 800
IDALLDCPLF LPDLEPGEKL ESMSAKDRSL MCSLTFLTFN WFREVVNAFC
810 820 830 840 850
QQTSPEMKGK VLSRLKDLVE LQEILEKYLA VIPDYVPPFT SVDLDTLDVI
860 870 880 890 900
PRSNSAVAAK SRHKGKTGGK KQKADSSTAS CTDTLLTEDT SECDVAPSGK
910 920 930 940 950
SQVDKESTGK EGKTFVSLQN YRAFFRELDI EVFSILHSGL VTKFILDTEM
960 970 980 990 1000
HTEATEVVQL GPAELLFLLE DLSQKLENRL TPSFTKRVCF FKNKGSRNIG
1010 1020 1030 1040 1050
FSHLHQRSVQ DIVHCVVQLL TPMCNHLENI HNFFQCLGAE NLSVNDKARV
1060 1070 1080 1090 1100
TAQEHYTMSS CYQKLLQVFH ALLAWKGFTH QSNHRLLRSA LEVLASRLKQ
1110 1120 1130 1140 1150
TEEGQPLEEL LSQSFSYLQN LQHSIPSFQC GLYLLRLLMA LLEKSAVPTQ
1160 1170 1180 1190 1200
KKEKLASLAK QLLCRAWPHG DKEKNPTFND HLHDLLCIYL EHTDNVLKAI
1210 1220 1230 1240 1250
EEITGVGVPE LVNAPKDASS STFPTLTRHT FVIFFRVMMA ELEKTVKGLQ
1260 1270 1280 1290 1300
AGTATDSQQV HEEKLLYWNM AVRDFSILIN LMKVFDSYPV LHVCLKYGRR
1310 1320 1330 1340 1350
FVEAFLKQCM PLLDFSFRKH RDDVLSLLQT LQLNTRLLHH LCGHSKIHQD
1360 1370 1380 1390 1400
TRLTKHVPLL KKSLELLVCR VKAMLVLNNC REAFWLGTLK NRDLQGEEII
1410 1420 1430 1440 1450
SQHPSSPENT SEDSEDGMTS YVSRNRAIED GEDEANDGQD RDSDESDDSS

S
Length:1,451
Mass (Da):163,621
Last modified:June 7, 2005 - v2
Checksum:i5FE7FC72DA46834D
GO

Sequence cautioni

The sequence AAT40425 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621075 mRNA. Translation: AAT40425.1. Different initiation.
RefSeqiNP_001001719.1. NM_001001719.1.
UniGeneiRn.203979.

Genome annotation databases

GeneIDi312641.
KEGGirno:312641.
UCSCiRGD:1303172. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621075 mRNA. Translation: AAT40425.1. Different initiation.
RefSeqiNP_001001719.1. NM_001001719.1.
UniGeneiRn.203979.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033638.

PTM databases

PhosphoSiteiQ6IV68.

Proteomic databases

PaxDbiQ6IV68.
PRIDEiQ6IV68.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi312641.
KEGGirno:312641.
UCSCiRGD:1303172. rat.

Organism-specific databases

CTDi2177.
RGDi1303172. Fancd2.

Phylogenomic databases

eggNOGiKOG4712. Eukaryota.
ENOG410XT6B. LUCA.
HOGENOMiHOG000060189.
HOVERGENiHBG060904.
InParanoidiQ6IV68.
KOiK10891.
PhylomeDBiQ6IV68.
TreeFamiTF101106.

Miscellaneous databases

PROiQ6IV68.

Gene expression databases

BgeeiENSRNOG00000024475.

Family and domain databases

InterProiIPR029448. FANCD2.
[Graphical view]
PfamiPF14631. FancD2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFACD2_RAT
AccessioniPrimary (citable) accession number: Q6IV68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 7, 2005
Last modified: September 7, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.