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Q6IV20

- GLL11_CHICK

UniProt

Q6IV20 - GLL11_CHICK

Protein

Gallinacin-11

Gene

GAL11

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has bactericidal activity.By similarity

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gallinacin-11
    Short name:
    Gal-11
    Alternative name(s):
    Beta-defensin 11
    Vitelline membrane outer layer protein 2
    Vitelline membrane outer layer protein II
    Short name:
    VMO-II
    Short name:
    VMOII
    Gene namesi
    Name:GAL11
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 10482Gallinacin-11PRO_0000288575Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 60By similarity
    Disulfide bondi37 ↔ 53By similarity
    Disulfide bondi43 ↔ 61By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ6IV20.

    Expressioni

    Tissue specificityi

    Detected in outer membrane of the vitelline layer of the egg (at protein level). Expressed in the liver, gall bladder, kidney, testis, ovary and male and female reproductive tracts. Expressed in the ovarian stroma, but not in the ovarian follicles. No expression is detected in bone marrow.3 Publications

    Gene expression databases

    ArrayExpressiQ6IV20.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000030908.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240114.
    GeneTreeiENSGT00530000069149.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6IV20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLFSCLMAL LLFLLQAVPG LGLPRDTSRC VGYHGYCIRS KVCPKPFAAF    50
    GTCSWRQKTC CVDTTSDFHT CQDKGGHCVS PKIRCLEEQL GLCPLKRWTC 100
    CKEI 104
    Length:104
    Mass (Da):11,650
    Last modified:July 5, 2004 - v1
    Checksum:i1D3E63B15D37F36A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311V → A in ABJ90336. 1 PublicationCurated
    Sequence conflicti34 – 341H → L in ABJ90336. 1 PublicationCurated
    Sequence conflicti94 – 941P → H in ABJ90336. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351G → R in strain: Huiyang bearded. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY621313 mRNA. Translation: AAT45551.1.
    AY621326 Genomic DNA. Translation: AAT48935.1.
    DQ677642 mRNA. Translation: ABG73376.1.
    DQ858308 mRNA. Translation: ABI48223.1.
    DQ858321 mRNA. Translation: ABI48237.1.
    DQ858334 mRNA. Translation: ABI48250.1.
    DQ858348 mRNA. Translation: ABI48264.1.
    DQ997047 mRNA. Translation: ABJ90336.1.
    PIRiS23981.
    RefSeqiNP_001001779.1. NM_001001779.1.
    UniGeneiGga.6496.

    Genome annotation databases

    EnsembliENSGALT00000031544; ENSGALP00000030908; ENSGALG00000019846.
    GeneIDi414876.
    KEGGigga:414876.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY621313 mRNA. Translation: AAT45551.1 .
    AY621326 Genomic DNA. Translation: AAT48935.1 .
    DQ677642 mRNA. Translation: ABG73376.1 .
    DQ858308 mRNA. Translation: ABI48223.1 .
    DQ858321 mRNA. Translation: ABI48237.1 .
    DQ858334 mRNA. Translation: ABI48250.1 .
    DQ858348 mRNA. Translation: ABI48264.1 .
    DQ997047 mRNA. Translation: ABJ90336.1 .
    PIRi S23981.
    RefSeqi NP_001001779.1. NM_001001779.1.
    UniGenei Gga.6496.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000030908.

    Proteomic databases

    PRIDEi Q6IV20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000031544 ; ENSGALP00000030908 ; ENSGALG00000019846 .
    GeneIDi 414876.
    KEGGi gga:414876.

    Organism-specific databases

    CTDi 414876.

    Phylogenomic databases

    eggNOGi NOG240114.
    GeneTreei ENSGT00530000069149.

    Miscellaneous databases

    NextBioi 20818754.

    Gene expression databases

    ArrayExpressi Q6IV20.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins."
      Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D., Zhang G.
      BMC Genomics 5:56-56(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    2. "Chicken beta-defensin in China chicken breeds."
      Chen Y., Cao Y., Xie Q., Bi Y., Chen J.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-35.
      Strain: Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies and Xinghua.
    3. "Cloning and structure analysis of the Chongren Ma chicken beta-defensin 11 (GAL11)."
      Kang X., Jiang R., Han R., Chen Q., Tian Y., Li G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Isolation of a novel protein from the outer layer of the vitelline membrane."
      Kido S., Morimoto A., Kim F., Doi Y.
      Biochem. J. 286:17-22(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-42, TISSUE SPECIFICITY.
      Tissue: Egg yolk.
    5. "Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus)."
      Subedi K., Isobe N., Nishibori M., Yoshimura Y.
      Reproduction 133:127-133(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGLL11_CHICK
    AccessioniPrimary (citable) accession number: Q6IV20
    Secondary accession number(s): A0A1W6, Q09MT4, Q9PS49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3