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Protein

Gallinacin-11

Gene

GAL11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has bactericidal activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Gallinacin-11
Short name:
Gal-11
Alternative name(s):
Beta-defensin 11
Vitelline membrane outer layer protein 2
Vitelline membrane outer layer protein II
Short name:
VMO-II
Short name:
VMOII
Gene namesi
Name:GAL11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000028857523 – 104Gallinacin-11Add BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 60By similarity
Disulfide bondi37 ↔ 53By similarity
Disulfide bondi43 ↔ 61By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6IV20.

Expressioni

Tissue specificityi

Detected in outer membrane of the vitelline layer of the egg (at protein level). Expressed in the liver, gall bladder, kidney, testis, ovary and male and female reproductive tracts. Expressed in the ovarian stroma, but not in the ovarian follicles. No expression is detected in bone marrow.3 Publications

Gene expression databases

BgeeiENSGALG00000019846.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030908.

Structurei

3D structure databases

ProteinModelPortaliQ6IV20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000069149.
InParanoidiQ6IV20.
OMAiFAAFGTC.
OrthoDBiEOG091G174G.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IV20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFSCLMAL LLFLLQAVPG LGLPRDTSRC VGYHGYCIRS KVCPKPFAAF
60 70 80 90 100
GTCSWRQKTC CVDTTSDFHT CQDKGGHCVS PKIRCLEEQL GLCPLKRWTC

CKEI
Length:104
Mass (Da):11,650
Last modified:July 5, 2004 - v1
Checksum:i1D3E63B15D37F36A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31V → A in ABJ90336 (Ref. 3) Curated1
Sequence conflicti34H → L in ABJ90336 (Ref. 3) Curated1
Sequence conflicti94P → H in ABJ90336 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti35G → R in strain: Huiyang bearded. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621313 mRNA. Translation: AAT45551.1.
AY621326 Genomic DNA. Translation: AAT48935.1.
DQ677642 mRNA. Translation: ABG73376.1.
DQ858308 mRNA. Translation: ABI48223.1.
DQ858321 mRNA. Translation: ABI48237.1.
DQ858334 mRNA. Translation: ABI48250.1.
DQ858348 mRNA. Translation: ABI48264.1.
DQ997047 mRNA. Translation: ABJ90336.1.
PIRiS23981.
RefSeqiNP_001001779.1. NM_001001779.1.
UniGeneiGga.6496.

Genome annotation databases

EnsembliENSGALT00000031544; ENSGALP00000030908; ENSGALG00000019846.
GeneIDi414876.
KEGGigga:414876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621313 mRNA. Translation: AAT45551.1.
AY621326 Genomic DNA. Translation: AAT48935.1.
DQ677642 mRNA. Translation: ABG73376.1.
DQ858308 mRNA. Translation: ABI48223.1.
DQ858321 mRNA. Translation: ABI48237.1.
DQ858334 mRNA. Translation: ABI48250.1.
DQ858348 mRNA. Translation: ABI48264.1.
DQ997047 mRNA. Translation: ABJ90336.1.
PIRiS23981.
RefSeqiNP_001001779.1. NM_001001779.1.
UniGeneiGga.6496.

3D structure databases

ProteinModelPortaliQ6IV20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030908.

Proteomic databases

PaxDbiQ6IV20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000031544; ENSGALP00000030908; ENSGALG00000019846.
GeneIDi414876.
KEGGigga:414876.

Organism-specific databases

CTDi414876.

Phylogenomic databases

GeneTreeiENSGT00530000069149.
InParanoidiQ6IV20.
OMAiFAAFGTC.
OrthoDBiEOG091G174G.

Miscellaneous databases

PROiQ6IV20.

Gene expression databases

BgeeiENSGALG00000019846.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiGLL11_CHICK
AccessioniPrimary (citable) accession number: Q6IV20
Secondary accession number(s): A0A1W6, Q09MT4, Q9PS49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.