Reviewed, UniProtKB/Swiss-Prot Q6IV20 (GLL11_CHICK)

Names and origin

Protein names

Recommended name:
    Gallinacin-11
      Short name=Gal-11
Alternative name(s):
    Beta-defensin 11

Gene names

Name:

GAL11

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has bactericidal activity By similarity.
Subcellular location	Secreted. Cytoplasmic granuleBy similarity.
Tissue specificity	Expressed in the liver, gall bladder, kidney, testis, ovary and male and female reproductive tracts. Ref.1
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 25	6	By similarity		PRO_0000288574
	Chain	26 – 104	79	Gallinacin-11		PRO_0000288575
Amino acid modifications
	Disulfide bond	30 ↔ 60		By similarity
	Disulfide bond	37 ↔ 53		By similarity
	Disulfide bond	43 ↔ 61		By similarity
Natural variations
	Natural variant	35	1	G → R in strain: Huiyang bearded. Ref.2
Experimental info
	Sequence conflict	31	1	V → A in ABJ90336. Ref.3
	Sequence conflict	34	1	H → L in ABJ90336. Ref.3
	Sequence conflict	94	1	P → H in ABJ90336. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q6IV20-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1D3E63B15D37F36A	FASTA	104	11,650
	10 20 30 40 50 60 MKLFSCLMAL LLFLLQAVPG LGLPRDTSRC VGYHGYCIRS KVCPKPFAAF GTCSWRQKTC 70 80 90 100 CVDTTSDFHT CQDKGGHCVS PKIRCLEEQL GLCPLKRWTC CKEI

References

[1]	"A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins." Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D., Zhang G. BMC Genomics 5:56-56(2004) [PubMed: 15310403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]	"Chicken beta-defensin in China chicken breeds." Chen Y., Cao Y., Xie Q., Bi Y., Chen J. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-35. Strain: Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies and Xinghua.
[3]	"Cloning and structure analysis of the Chongren Ma chicken beta-defensin 11 (GAL11)." Kang X., Jiang R., Han R., Chen Q., Tian Y., Li G. Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY621313 mRNA. Translation: AAT45551.1. AY621326 Genomic DNA. Translation: AAT48935.1. DQ677642 mRNA. Translation: ABG73376.1. DQ858308 mRNA. Translation: ABI48223.1. DQ858321 mRNA. Translation: ABI48237.1. DQ858334 mRNA. Translation: ABI48250.1. DQ858348 mRNA. Translation: ABI48264.1. DQ997047 mRNA. Translation: ABJ90336.1.
RefSeq	NP_001001779.1.
UniGene	Gga.6496
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000019846. Gallus gallus. [Contig view]
GeneID	414876.
KEGG	gga:414876.
Phylogenomic databases
HOVERGEN	Q6IV20.
Family and domain databases
InterPro	IPR001855. Defensin_beta. [Graphical view]
Pfam	PF00711. Defensin_beta. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLL11_CHICK

Accession

Primary (citable) accession number: Q6IV20
Secondary accession number(s): A0A1W6, Q09MT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	July 5, 2004
Last modified:	November 25, 2008
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)