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Protein

Gallinacin-11

Gene

GAL11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has bactericidal activity.By similarity

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Gallinacin-11
Short name:
Gal-11
Alternative name(s):
Beta-defensin 11
Vitelline membrane outer layer protein 2
Vitelline membrane outer layer protein II
Short name:
VMO-II
Short name:
VMOII
Gene namesi
Name:GAL11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 10482Gallinacin-11PRO_0000288575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 60By similarity
Disulfide bondi37 ↔ 53By similarity
Disulfide bondi43 ↔ 61By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6IV20.

Expressioni

Tissue specificityi

Detected in outer membrane of the vitelline layer of the egg (at protein level). Expressed in the liver, gall bladder, kidney, testis, ovary and male and female reproductive tracts. Expressed in the ovarian stroma, but not in the ovarian follicles. No expression is detected in bone marrow.3 Publications

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030908.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240114.
GeneTreeiENSGT00530000069149.
InParanoidiQ6IV20.
OMAiFAAFGTC.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6IV20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLFSCLMAL LLFLLQAVPG LGLPRDTSRC VGYHGYCIRS KVCPKPFAAF
60 70 80 90 100
GTCSWRQKTC CVDTTSDFHT CQDKGGHCVS PKIRCLEEQL GLCPLKRWTC

CKEI
Length:104
Mass (Da):11,650
Last modified:July 5, 2004 - v1
Checksum:i1D3E63B15D37F36A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311V → A in ABJ90336. 1 PublicationCurated
Sequence conflicti34 – 341H → L in ABJ90336. 1 PublicationCurated
Sequence conflicti94 – 941P → H in ABJ90336. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351G → R in strain: Huiyang bearded. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621313 mRNA. Translation: AAT45551.1.
AY621326 Genomic DNA. Translation: AAT48935.1.
DQ677642 mRNA. Translation: ABG73376.1.
DQ858308 mRNA. Translation: ABI48223.1.
DQ858321 mRNA. Translation: ABI48237.1.
DQ858334 mRNA. Translation: ABI48250.1.
DQ858348 mRNA. Translation: ABI48264.1.
DQ997047 mRNA. Translation: ABJ90336.1.
PIRiS23981.
RefSeqiNP_001001779.1. NM_001001779.1.
UniGeneiGga.6496.

Genome annotation databases

EnsembliENSGALT00000031544; ENSGALP00000030908; ENSGALG00000019846.
GeneIDi414876.
KEGGigga:414876.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY621313 mRNA. Translation: AAT45551.1.
AY621326 Genomic DNA. Translation: AAT48935.1.
DQ677642 mRNA. Translation: ABG73376.1.
DQ858308 mRNA. Translation: ABI48223.1.
DQ858321 mRNA. Translation: ABI48237.1.
DQ858334 mRNA. Translation: ABI48250.1.
DQ858348 mRNA. Translation: ABI48264.1.
DQ997047 mRNA. Translation: ABJ90336.1.
PIRiS23981.
RefSeqiNP_001001779.1. NM_001001779.1.
UniGeneiGga.6496.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030908.

Proteomic databases

PRIDEiQ6IV20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000031544; ENSGALP00000030908; ENSGALG00000019846.
GeneIDi414876.
KEGGigga:414876.

Organism-specific databases

CTDi414876.

Phylogenomic databases

eggNOGiNOG240114.
GeneTreeiENSGT00530000069149.
InParanoidiQ6IV20.
OMAiFAAFGTC.

Miscellaneous databases

NextBioi20818754.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "A genome-wide screen identifies a single beta-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins."
    Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D., Zhang G.
    BMC Genomics 5:56-56(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  2. "Chicken beta-defensin in China chicken breeds."
    Chen Y., Cao Y., Xie Q., Bi Y., Chen J.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-35.
    Strain: Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies and Xinghua.
  3. "Cloning and structure analysis of the Chongren Ma chicken beta-defensin 11 (GAL11)."
    Kang X., Jiang R., Han R., Chen Q., Tian Y., Li G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Isolation of a novel protein from the outer layer of the vitelline membrane."
    Kido S., Morimoto A., Kim F., Doi Y.
    Biochem. J. 286:17-22(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-42, TISSUE SPECIFICITY.
    Tissue: Egg yolk.
  5. "Changes in the expression of gallinacins, antimicrobial peptides, in ovarian follicles during follicular growth and in response to lipopolysaccharide in laying hens (Gallus domesticus)."
    Subedi K., Isobe N., Nishibori M., Yoshimura Y.
    Reproduction 133:127-133(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGLL11_CHICK
AccessioniPrimary (citable) accession number: Q6IV20
Secondary accession number(s): A0A1W6, Q09MT4, Q9PS49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.