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Q6IUR4 (PYRF_CANGY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismCandida glycerinogenes (Yeast)
Taxonomic identifier272698 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Orotidine 5'-phosphate decarboxylase
PRO_0000134650

Regions

Region57 – 593Substrate binding By similarity
Region89 – 9810Substrate binding By similarity

Sites

Active site911Proton donor By similarity
Binding site351Substrate By similarity
Binding site2151Substrate By similarity
Binding site2331Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6IUR4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: B0F0012C0A5B980A

FASTA26229,130
        10         20         30         40         50         60 
MASYKERSES HTSPVARRLF SIMEEKKSNL CASLDITETE KLLSILDTIG PYICLVKTHI 

        70         80         90        100        110        120 
DIVSDFTYEG TVLPLKELAK KHNFMIFEDR KFADIGNTVK NQYKSGVFRI AEWADITNAH 

       130        140        150        160        170        180 
GVTGAGIVSG LKEAAQETTS EPRGLLMLAE LSSKGSLAYG EYTEKTVEIA KSDKEFVIGF 

       190        200        210        220        230        240 
IAQHDMGGRE EGFDWIIMTP GVGLDDKGDA LGQQYRTVDE VVKTGTDIII VGRGLYGQGR 

       250        260 
DPIEQAKRYQ QAGWNAYLNR FK 

« Hide

References

[1]"Isolation and sequence analysis of the gene URA3 encoding the orotidine-5'-monophosphate decarboxylase from the yeast Candida glycerinogenes."
Li Y., Shen W., Rao Z., Fang H., Zhuge J.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY623794 mRNA. Translation: AAT39474.1.

3D structure databases

ProteinModelPortalQ6IUR4.
SMRQ6IUR4. Positions 2-260.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CANGY
AccessionPrimary (citable) accession number: Q6IUR4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways