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Q6IUR4

- PYRF_CANGY

UniProt

Q6IUR4 - PYRF_CANGY

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
URA3
Organism
Candida glycerinogenes (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351Substrate By similarity
Active sitei91 – 911Proton donor By similarity
Binding sitei215 – 2151Substrate By similarity
Binding sitei233 – 2331Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiCandida glycerinogenes (Yeast)
Taxonomic identifieri272698 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Orotidine 5'-phosphate decarboxylasePRO_0000134650Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6IUR4.
SMRiQ6IUR4. Positions 2-260.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 593Substrate binding By similarity
Regioni89 – 9810Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IUR4-1 [UniParc]FASTAAdd to Basket

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MASYKERSES HTSPVARRLF SIMEEKKSNL CASLDITETE KLLSILDTIG    50
PYICLVKTHI DIVSDFTYEG TVLPLKELAK KHNFMIFEDR KFADIGNTVK 100
NQYKSGVFRI AEWADITNAH GVTGAGIVSG LKEAAQETTS EPRGLLMLAE 150
LSSKGSLAYG EYTEKTVEIA KSDKEFVIGF IAQHDMGGRE EGFDWIIMTP 200
GVGLDDKGDA LGQQYRTVDE VVKTGTDIII VGRGLYGQGR DPIEQAKRYQ 250
QAGWNAYLNR FK 262
Length:262
Mass (Da):29,130
Last modified:July 5, 2004 - v1
Checksum:iB0F0012C0A5B980A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY623794 mRNA. Translation: AAT39474.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY623794 mRNA. Translation: AAT39474.1 .

3D structure databases

ProteinModelPortali Q6IUR4.
SMRi Q6IUR4. Positions 2-260.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and sequence analysis of the gene URA3 encoding the orotidine-5'-monophosphate decarboxylase from the yeast Candida glycerinogenes."
    Li Y., Shen W., Rao Z., Fang H., Zhuge J.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPYRF_CANGY
AccessioniPrimary (citable) accession number: Q6IUR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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