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Protein

Elongator complex protein 5

Gene

Elp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. May be involved in TP53-mediated transcriptional regulation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 5
Alternative name(s):
Dermal papilla-derived protein 6 homolog
Retinoic acid-induced protein 12
Gene namesi
Name:Elp5
Synonyms:Derp6, Rai12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303303. Elp5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Elongator complex protein 5PRO_0000280819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6IUP3.
PeptideAtlasiQ6IUP3.
PRIDEiQ6IUP3.

PTM databases

PhosphoSiteiQ6IUP3.

Expressioni

Gene expression databases

GenevisibleiQ6IUP3. RN.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6; in the complex, is required for optimal binding of ELP3 to ELP4.By similarity

Protein-protein interaction databases

BioGridi252166. 1 interaction.
STRINGi10116.ENSRNOP00000035345.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP5 family.Curated

Phylogenomic databases

eggNOGiENOG410IZJG. Eukaryota.
ENOG411201Y. LUCA.
HOVERGENiHBG081433.
InParanoidiQ6IUP3.
OMAiNSRLVYH.
OrthoDBiEOG70PBZX.

Family and domain databases

InterProiIPR019519. Elp5.
[Graphical view]
PANTHERiPTHR15641. PTHR15641. 1 hit.
PfamiPF10483. Elong_Iki1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6IUP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLLSGDDI RRRPEASEML DSLLATGGLV LLRDSVEWEG RGLLKALIKK
60 70 80 90 100
SALRGEQVHV LGCEVSEEEF REGLGSDVNS RLVYHDLFRD PLNWSQPGEA
110 120 130 140 150
APEGPLKALR SMCRRTDRGS VTIALDSLSW LLCHIPCVTL CQALHALSQR
160 170 180 190 200
NVDPGDNPLI EQVRVLGLLH EELHGPGPVG AVSSLAHTEV TLSGKMDQTS
210 220 230 240 250
ASILCRRPQQ RATYQTWWFS ILPDFSLDLH EGLPLHSELH RDPHTTQVDP
260 270 280 290 300
ASHLTFNLHL SKKEREAKDS LTLPFQFSSE KQQALLHPVP GQTTGRIFYE
310
PDAFDDVDQE DPDDDLDI
Length:318
Mass (Da):35,490
Last modified:July 5, 2004 - v1
Checksum:i39E9C43AA98CA7F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623900 mRNA. Translation: AAT40590.1.
RefSeqiNP_001001718.1. NM_001001718.1.
UniGeneiRn.9041.

Genome annotation databases

GeneIDi287446.
KEGGirno:287446.
UCSCiRGD:1303303. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623900 mRNA. Translation: AAT40590.1.
RefSeqiNP_001001718.1. NM_001001718.1.
UniGeneiRn.9041.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi252166. 1 interaction.
STRINGi10116.ENSRNOP00000035345.

PTM databases

PhosphoSiteiQ6IUP3.

Proteomic databases

PaxDbiQ6IUP3.
PeptideAtlasiQ6IUP3.
PRIDEiQ6IUP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi287446.
KEGGirno:287446.
UCSCiRGD:1303303. rat.

Organism-specific databases

CTDi23587.
RGDi1303303. Elp5.

Phylogenomic databases

eggNOGiENOG410IZJG. Eukaryota.
ENOG411201Y. LUCA.
HOVERGENiHBG081433.
InParanoidiQ6IUP3.
OMAiNSRLVYH.
OrthoDBiEOG70PBZX.

Miscellaneous databases

PROiQ6IUP3.

Gene expression databases

GenevisibleiQ6IUP3. RN.

Family and domain databases

InterProiIPR019519. Elp5.
[Graphical view]
PANTHERiPTHR15641. PTHR15641. 1 hit.
PfamiPF10483. Elong_Iki1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a novel rat DERP6 gene."
    Yuan J., Shan Y.X.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiELP5_RAT
AccessioniPrimary (citable) accession number: Q6IUP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-19 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.