ID   LAIR2_HUMAN             Reviewed;         152 AA.
AC   Q6ISS4; Q6PEZ4;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   19-JAN-2010, entry version 53.
DE   RecName: Full=Leukocyte-associated immunoglobulin-like receptor 2;
DE            Short=LAIR-2;
DE   AltName: CD_antigen=CD306;
DE   Flags: Precursor;
GN   Name=LAIR2; Synonyms=CD306;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=9285412; DOI=10.1016/S1074-7613(00)80530-0;
RA   Meyaard L., Adema G.J., Chang C., Woollatt E., Sutherland G.R.,
RA   Lanier L.L., Phillips J.H.;
RT   "LAIR-1, a novel inhibitory receptor expressed on human mononuclear
RT   leukocytes.";
RL   Immunity 7:283-290(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=10229813;
RA   Meyaard L., Hurenkamp J., Clevers H., Lanier L.L., Phillips J.H.;
RT   "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory
RT   receptor on cytotoxic T cells.";
RL   J. Immunol. 162:5800-5804(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Named isoforms=2;
CC       Name=1; Synonyms=LAIR-2a;
CC         IsoId=Q6ISS4-1; Sequence=Displayed;
CC       Name=2; Synonyms=LAIR-2b;
CC         IsoId=Q6ISS4-2; Sequence=VSP_020720;
CC   -!- SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like)
CC       domain.
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DR   EMBL; AF013250; AAB69325.1; -; mRNA.
DR   EMBL; AA133246; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC069366; AAH69366.1; -; mRNA.
DR   IPI; IPI00010137; -.
DR   IPI; IPI00032545; -.
DR   RefSeq; NP_002279.2; -.
DR   RefSeq; NP_067154.1; -.
DR   UniGene; Hs.43803; -.
DR   HSSP; Q8NHL6; 1VDG.
DR   SMR; Q6ISS4; 26-120.
DR   STRING; Q6ISS4; -.
DR   Ensembl; ENST00000301202; ENSP00000301202; ENSG00000167618; Homo sapiens.
DR   GeneID; 3904; -.
DR   KEGG; hsa:3904; -.
DR   UCSC; uc002qgc.1; human.
DR   UCSC; uc002qgd.1; human.
DR   CTD; 3904; -.
DR   GeneCards; GC19P059705; -.
DR   HGNC; HGNC:6478; LAIR2.
DR   MIM; 602993; gene.
DR   PharmGKB; PA30267; -.
DR   eggNOG; prNOG12108; -.
DR   InParanoid; Q6ISS4; -.
DR   OMA; FRLGPSE; -.
DR   PhylomeDB; Q6ISS4; -.
DR   NextBio; 15327; -.
DR   ArrayExpress; Q6ISS4; -.
DR   Bgee; Q6ISS4; -.
DR   CleanEx; HS_LAIR2; -.
DR   Genevestigator; Q6ISS4; -.
DR   GermOnline; ENSG00000167618; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1.
DR   SMART; SM00409; IG; 1.
DR   PROSITE; PS50835; IG_LIKE; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Disulfide bond;
KW   Immunoglobulin domain; Polymorphism; Receptor; Secreted; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22    152       Leukocyte-associated immunoglobulin-like
FT                                receptor 2.
FT                                /FTId=PRO_0000250685.
FT   DOMAIN       29    117       Ig-like C2-type.
FT   DISULFID     49    101       By similarity.
FT   VAR_SEQ     122    138       Missing (in isoform 2).
FT                                /FTId=VSP_020720.
FT   VARIANT      78     78       G -> S (in dbSNP:rs36121405).
FT                                /FTId=VAR_049882.
FT   VARIANT      87     87       H -> R (in dbSNP:rs34423078).
FT                                /FTId=VAR_049883.
FT   VARIANT     115    115       F -> Y (in dbSNP:rs34429135).
FT                                /FTId=VAR_049884.
SQ   SEQUENCE   152 AA;  16280 MW;  8097688A9DB42EC8 CRC64;
     MSPHLTALLG LVLCLAQTIH TQEGALPRPS ISAEPGTVIS PGSHVTFMCR GPVGVQTFRL
     EREDRAKYKD SYNVFRLGPS ESEARFHIDS VSEGNAGLYR CLYYKPPGWS EHSDFLELLV
     KESSGGPDSP DTEPGSSAGT VPGTEASGFD AP
//